Long-Term Risk of Breast Cancer after Diagnosis of Benign Breast Disease by Screening Mammography
Por:
Roman, M, Louro, J, Posso, M, Vidal, C, Bargallo, X, Vazquez, I, Quintana, MJ, Alcantara, R, Saladie, F, del Riego, J, Penalva, L, Sala, M, Castells, X
Publicada:
1 mar 2022
Resumen:
Assessing the long-term risk of breast cancer after diagnosis of benign breast disease by mammography is of utmost importance to design personalised screening strategies. We analysed individual-level data from 778,306 women aged 50-69 years with at least one mammographic screening participation in any of ten breast cancer screening centers in Spain from 1996 to 2015, and followed-up until 2017. We used Poisson regression to compare the rates of incident breast cancer among women with and without benign breast disease. During a median follow-up of 7.6 years, 11,708 (1.5%) women had an incident of breast cancer and 17,827 (2.3%) had a benign breast disease. The risk of breast cancer was 1.77 times higher among women with benign breast disease than among those without (95% CI: 1.61 to 1.95). The relative risk increased to 1.99 among women followed for less than four years, and remained elevated for two decades, with relative risk 1.96 (95% CI: 1.32 to 2.92) for those followed from 12 to 20 years. Benign breast disease is a long-term risk factor for breast cancer. Women with benign breast disease could benefit from closer surveillance and personalized screening strategies.
Filiaciones:
Roman, M:
IMIM Hosp del Mar Med Res Inst, Epidemiol & Evaluat Dept, Barcelona 08003, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona 08003, Spain
Louro, J:
IMIM Hosp del Mar Med Res Inst, Epidemiol & Evaluat Dept, Barcelona 08003, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona 08003, Spain
Posso, M:
IMIM Hosp del Mar Med Res Inst, Epidemiol & Evaluat Dept, Barcelona 08003, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona 08003, Spain
Vidal, C:
Catalan Inst Oncol ICO, Canc Prevent & Monitoring Program, Barcelona 08908, Spain
Bargallo, X:
Hosp Clin Barcelona, Dept Radiol, Barcelona 08036, Spain
Vazquez, I:
IMIM Hosp del Mar Med Res Inst, Pathol Dept, Barcelona 08003, Spain
Quintana, MJ:
Univ Hosp Santa Creu & St Pau, Dept Clin Epidemiol & Publ Hlth, Barcelona 08025, Spain
Alcantara, R:
IMIM Hosp del Mar Med Res Inst, Radiol Dept, Barcelona 08003, Spain
Saladie, F:
Hosp Univ St Joan Reus, IISPV, Epidemiol & Canc Prevent Serv, Reus 43204, Spain
del Riego, J:
Parc Tauli Univ Hosp UAB, Dept Radiol, Sabadell 08208, Spain
Penalva, L:
Private Fdn Asil Hosp, Breast Canc Screening Tech Off, Granollers 08402, Spain
Sala, M:
IMIM Hosp del Mar Med Res Inst, Epidemiol & Evaluat Dept, Barcelona 08003, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona 08003, Spain
Castells, X:
IMIM Hosp del Mar Med Res Inst, Epidemiol & Evaluat Dept, Barcelona 08003, Spain
Res Network Hlth Serv Chron Dis REDISSEC, Barcelona 08003, Spain
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