Post-COVID-19 fatigue: the contribution of cognitive and neuropsychiatric symptoms
Por:
Calabria, M, Garcia-Sanchez, C, Grunden, N, Pons, C, Arroyo, JA, Gomez-Anson, B, Garcia, MDE, Belvis, R, Morollon, N, Igual, JV, Mur, I, Pomar, V, Domingo, P
Publicada:
1 ago 2022
Ahead of Print:
1 abr 2022
Resumen:
Fatigue in its many forms of physical, mental, and psychosocial exhaustion is a common symptom of post-COVID-19 condition, also known as "Long COVID." Persistent fatigue in COVID-19 patients is frequently accompanied by cognitive dysfunction and neuropsychiatric symptoms; however, less is known about the relationships between these components of post-COVID-19 condition and fatigue itself. Consequently, the present study sought to (1) distinguish the types of fatigue experienced by participants, and (2) investigate whether cognitive deficits across various domains and neuropsychiatric conditions predicted these different types of fatigue. The study included 136 COVID-19 patients referred for neuropsychological evaluation due to cognitive complaints 8 months on average after SARS-CoV-2 infection. Measures included self-reported fatigue (physical, cognitive, and psychosocial), neuropsychiatric questionnaires (assessing symptoms of depression, anxiety, apathy, and executive functioning), a comprehensive neuropsychological assessment, and self-reported quality of life and everyday functioning. Results showed that reports of clinical significant fatigue were pervasive in our sample (82.3% of participants), with physical fatigue rated highest on average relative to the subscale maximum. Elevated levels of apathy, anxiety, and executive dysfunction in neuropsychiatric measures along with executive and attentional difficulties on cognitive tests were found to be consistently important predictors among different types of fatigue. This implicates both cognitive and neuropsychiatric symptoms as predictors of fatigue in post-COVID-19 condition, and stresses the importance of a holistic approach in assessing and considering potential treatment for COVID-19 patients experiencing fatigue.
Filiaciones:
Calabria, M:
Univ Oberta Catalunya, Fac Hlth Sci, Cognit NeuroLab, Barcelona, Spain
Garcia-Sanchez, C:
Hosp Santa Creu & Sant Pau, Neuropsychol Unit, Neurol Dept, Barcelona, Spain
Grunden, N:
Concordia Univ, Dept Psychol, Montreal, PQ, Canada
Ctr Res Brain Language & Mus, Montreal, PQ, Canada
Pons, C:
Univ Ramon Llull, Fac Psicol Ciencies Educ & Esport, Barcelona, Spain
Arroyo, JA:
Hosp Santa Creu & Sant Pau, Internal Med Dept, Barcelona, Spain
Gomez-Anson, B:
Hosp Santa Creu & Sant Pau, Neuroradiol, Dept Radiol, Barcelona, Spain
Univ Autonoma Barcelona UAB, Barcelona, Spain
Garcia, MDE:
Hosp Santa Creu & Sant Pau, Neuropsychol Unit, Neurol Dept, Barcelona, Spain
Belvis, R:
Hosp Santa Creu & Sant Pau, Headache Unit, Neurol Dept, Barcelona, Spain
Morollon, N:
Hosp Santa Creu & Sant Pau, Headache Unit, Neurol Dept, Barcelona, Spain
Igual, JV:
Hosp Santa Creu & Sant Pau, Psychiat Dept, Barcelona, Spain
Mur, I:
Hosp Santa Creu & Sant Pau, Infect Dis Unit, Barcelona, Spain
Pomar, V:
Hosp Santa Creu & Sant Pau, Infect Dis Unit, Barcelona, Spain
Domingo, P:
Hosp Santa Creu & Sant Pau, Infect Dis Unit, Barcelona, Spain
Green Published, hybrid, All Open Access; Hybrid Gold
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