Indirect Treatment Comparison of Baricitinib versus Dupilumab in Adults with Moderate-to-Severe Atopic Dermatitis
Por:
de Bruin-Weller, MS, Serra-Baldrich, E, Barbarot, S, Grond, S, Schuster, C, Petto, H, Capron, JP, Raibouaa, A, Werfel, T
Publicada:
1 jun 2022
Ahead of Print:
1 may 2022
Resumen:
Introduction Indirect treatment comparison was used to compare approved doses of baricitinib and dupilumab for treating adult patients with moderate-to-severe atopic dermatitis (AD) who are candidates for systemic therapy. Methods Baricitinib and dupilumab were compared (Bucher method) at weeks 4 and 16. Performance in combination with topical corticosteroids (TCS) was analyzed in patients with inadequate response or inadvisable to topical therapies (population A) and cyclosporine (population B). Population A was additionally examined as monotherapy. Results For the Eczema Area and Severity Index (EASI) 75, baricitinib and dupilumab were similar. A >= 4-point improvement in itch numerical rating scale (NRS) was significantly more likely with baricitinib 4 mg than dupilumab in population A as monotherapy (RR = 2.62, 95% CI 1.22, 5.61, p = 0.013) and in TCS combination at week 4. These differences were not significant by week 16. For the Dermatology Life Quality Index (DLQI), baricitinib 4 mg and dupilumab were similar on mean difference in change from baseline (MDcfb), though some differences were seen between baricitinib 2 mg and dupilumab at week 16 for the population A monotherapy (MDcfb = 2.05, 95% CI 0.53, 3.56, p = 0.016) and TCS combination therapy (MDcfb = 2.48, 95% CI 0.46, 4.50, p = 0.016) groups, and in population B (MDcfb = 3.38 95% CI 1.18, 5.58, p = 0.003). Conclusions Baricitinib potentially offers more rapid improvement in itch while providing similar efficacy on EASI75 and DLQI outcomes compared with dupilumab.
Filiaciones:
de Bruin-Weller, MS:
Univ Med Ctr, Dept Dermatol & Allergol, Utrecht, Netherlands
Serra-Baldrich, E:
Univ Autonoma Barcelona, Hosp St Pau, Dept Dermatol, Cutaneous Allergy Unit, Barcelona, Spain
Barbarot, S:
Nantes Univ, Dept Dermatol, CHU Nantes, INRAE,UMR 1280 PhAN, F-44000 Nantes, France
Grond, S:
Eli Lilly & Co, Indianapolis, IN 46285 USA
Schuster, C:
Eli Lilly & Co, Indianapolis, IN 46285 USA
Petto, H:
Eli Lilly & Co, Indianapolis, IN 46285 USA
Capron, JP:
Eli Lilly & Co, Indianapolis, IN 46285 USA
Raibouaa, A:
Eli Lilly & Co, Indianapolis, IN 46285 USA
Werfel, T:
Hannover Med Sch, Dept Dermatol & Allergy, Div Immunodermatol & Allergy Res, Hannover, Germany
gold, Gold
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