Mechanisms, therapeutic implications, and methodological challenges of gut microbiota and cardiovascular diseases: a position paper by the ESC Working Group on Coronary Pathophysiology and Microcirculation
Por:
Tousoulis, D, Guzik, T, Padro, T, Duncker, DJ, De Luca, G, Eringa, E, Vavlukis, M, Antonopoulos, AS, Katsimichas, T, Cenko, E, Djordjevic-Dikic, A, Fleming, I, Manfrini, O, Trifunovic, D, Antoniades, C, Crea, F
Publicada:
1 dic 2022
Ahead of Print:
1 may 2022
Resumen:
The human gut microbiota is the microbial ecosystem in the small and large intestines of humans. It has been naturally preserved and evolved to play an important role in the function of the gastrointestinal tract and the physiology of its host, protecting from pathogen colonization, and participating in vitamin synthesis, the functions of the immune system, as well as glucose homeostasis and lipid metabolism, among others. Mounting evidence from animal and human studies indicates that the composition and metabolic profiles of the gut microbiota are linked to the pathogenesis of cardiovascular disease, particularly arterial hypertension, atherosclerosis, and heart failure. In this review article, we provide an overview of the function of the human gut microbiota, summarize, and critically address the evidence linking compositional and functional alterations of the gut microbiota with atherosclerosis and coronary artery disease and discuss the potential of strategies for therapeutically targeting the gut microbiota through various interventions.
Filiaciones:
Tousoulis, D:
Natl & Kapodistrian Univ Athens, Dept Cardiol 1, Vas Sofias Ave 114, Athens 11527, Greece
Guzik, T:
BHF Glasgow Cardiovasc Res Ctr, Inst Cardiovasc Med Sci, Glasgow, Lanark, Scotland
Padro, T:
Sant Pau Inst Biomed Res, Barcelona, Spain
Duncker, DJ:
Erasmus MC, Dept Cardiol, Ctr Thorax, Rotterdam, Netherlands
De Luca, G:
Univ Piemonte Orientale, Div Cardiol, Novara, Italy
Eringa, E:
Amsterdam Univ Med Ctr, Inst Cardiovascular Res, Amsterdam, Netherlands
Vavlukis, M:
Univ Ss Cyril & Methodius, Skopje, North Macedonia
Antonopoulos, AS:
Natl & Kapodistrian Univ Athens, Dept Cardiol 1, Vas Sofias Ave 114, Athens 11527, Greece
Katsimichas, T:
Natl & Kapodistrian Univ Athens, Dept Cardiol 1, Vas Sofias Ave 114, Athens 11527, Greece
Cenko, E:
Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy
Djordjevic-Dikic, A:
Univ Clin Ctr Serbia, Belgrade, Serbia
Fleming, I:
Goethe Univ, Ctr Mol Med, Frankfurt, Germany
Manfrini, O:
Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy
Trifunovic, D:
Univ Belgrade, Dept Cardiol, Belgrade, Serbia
Antoniades, C:
Univ Oxford, RDM Div Cardiovasc Med, Oxford, England
Crea, F:
Univ Cattolica Sacro Cuore, Dept Cardiol & Pulm Sci, Rome, Italy
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