Relationship between clinical and BK virological response in patients with late hemorrhagic cystitis treated with cidofovir: a retrospective study from the European Group for Blood and Marrow Transplantation
Por:
Cesaro, S, Pillon, M, Tridello, G, Aljurf, M, Martino, R, Schroyens, W, Nozzoli, C, Barba, P, Faraci, M, Fagioli, F, Cappelli, B, Cordonnier, C, Al-Mohareb, F, Floisand, Y, Greil, J, Panizzolo, IS, Santarone, S
Publicada:
1 jun 2013
Resumen:
To investigate the relationship between clinical response and modification of BK viremia, we assessed retrospectively 32 cases of hemorrhagic cystitis (HC) after allogeneic hematopoietic SCT that were treated with i.v. cidofovir (CDV). They were 22 men (69%) and 10 women (31%) with a median age of 24 years, range 3-62. The median number of CDV doses was 3, range 1-8, and the treatment lasted for a median of 3 weeks, range 1-10. Clinical improvement of HC was observed in 27 patients (84%). In 12 of 32 episodes (37.5%), BK viremia was determined before every CDV administration and a complete clinical response was observed in 10 of 12 patients (83%), the reduction of BK viremia load being >= 1 log by 2 weeks after starting CDV. Nephrotoxicity related to CDV was observed in nine patients. Among 26 patients with 100-day follow-up, 4 of 4 patients who had a complete clinical response by 30 days were alive vs 16 of 22 (73%) who did not have the resolution of HC in this time frame. We conclude that in patients with HC, the response to CDV treatment is usually associated with a significant reduction of BK viremia load.
Filiaciones:
Cesaro, S:
Azienda Osped Univ Integrata, I-1037134 Verona, Italy
Pillon, M:
Univ Padua, Dept Pediat, Padua, Italy
Tridello, G:
Azienda Osped Univ Integrata, I-1037134 Verona, Italy
Aljurf, M:
King Faisal Specialist Hosp & Res Ctr, Adult HSCT Program, Riyadh 11211, Saudi Arabia
Martino, R:
Hosp Santa Creu & Sant Pau, Clin Hematol Div, Barcelona, Spain
Schroyens, W:
Antwerp Univ Hosp UZA, Dept Hematol, Antwerp, Belgium
Nozzoli, C:
Osped Careggi, Dept Hematol, BMT Unit, Florence, Italy
Barba, P:
Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain
Faraci, M:
Inst G Gaslini, Dept Hematol, Genoa, Italy
Fagioli, F:
Osped Infantile Regina Margherita, Turin, Italy
Cappelli, B:
Ist Sci San Raffaele, I-20132 Milan, Italy
Cordonnier, C:
Henri Mondor Univ Hosp, Dept Hematol, Creteil, France
Al-Mohareb, F:
King Faisal Specialist Hosp & Res Ctr, Adult HSCT Program, Riyadh 11211, Saudi Arabia
Floisand, Y:
Univ Oslo, Rikshosp, Dept Med, N-0027 Oslo, Norway
Greil, J:
Heidelberg Univ, Clin Hematol Div, Heidelberg, Germany
Panizzolo, IS:
Azienda Osped Univ Integrata, I-1037134 Verona, Italy
Santarone, S:
Osped Civile, Dept Hematol, Pescara, Italy
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