Cognitive frailty: Rational and definition from an (IANA/IAGG) International Consensus Group
Por:
Kelaiditi, E, Cesari, M, Canevelli, M, Van Kan, GA, Ousset, PJ, Gillette-Guyonnet, S, Ritz, P, Duveau, F, Soto, ME, Provencher, V, Nourhashemi, F, Salva, A, Robert, P, Andrieu, S, Rolland, Y, Touchon, J, Fitten, JL, Vellas, B
Publicada:
1 sep 2013
Resumen:
The frailty syndrome has recently attracted attention of the scientific community and public health organizations as precursor and contributor of age-related conditions (particularly disability) in older persons. In parallel, dementia and cognitive disorders also represent major healthcare and social priorities. Although physical frailty and cognitive impairment have shown to be related in epidemiological studies, their pathophysiological mechanisms have been usually studied separately. An International Consensus Group on "Cognitive Frailty" was organized by the International Academy on Nutrition and Aging (I.A.N.A) and the International Association of Gerontology and Geriatrics (I.A.G.G) on April 16th, 2013 in Toulouse (France). The present report describes the results of the Consensus Group and provides the first definition of a "Cognitive Frailty" condition in older adults. Specific aim of this approach was to facilitate the design of future personalized preventive interventions in older persons. Finally, the Group discussed the use of multidomain interventions focused on the physical, nutritional, cognitive and psychological domains for improving the well-being and quality of life in the elderly. The consensus panel proposed the identification of the so-called "cognitive frailty" as an heterogeneous clinical manifestation characterized by the simultaneous presence of both physical frailty and cognitive impairment. In particular, the key factors defining such a condition include: 1) presence of physical frailty and cognitive impairment (CDR=0.5); and 2) exclusion of concurrent AD dementia or other dementias. Under different circumstances, cognitive frailty may represent a precursor of neurodegenerative processes. A potential for reversibility may also characterize this entity. A psychological component of the condition is evident and concurs at increasing the vulnerability of the individual to stressors.
Filiaciones:
Kelaiditi, E:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Cesari, M:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Univ Toulouse III Paul Sabatier, F-31000 Toulouse, France
Canevelli, M:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Univ Roma La Sapienza, Dept Neurol & Psychiat, Memory Clin, Rome, Italy
Van Kan, GA:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Ousset, PJ:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Gillette-Guyonnet, S:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Ritz, P:
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Hop Rangueil, Pole Cardiovasc & Metab, Unite Transversale Nutr Clin, Toulouse, France
Duveau, F:
Medeos Consulting, Garches, France
Soto, ME:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Provencher, V:
Univ Laval, Dept Readaptat, Quebec City, PQ, Canada
Chu Quebec, Ctr Rech, Quebec City, PQ, Canada
Nourhashemi, F:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Salva, A:
Univ Autonoma Barcelona, Inst Catala Envelliment, E-08193 Barcelona, Spain
Robert, P:
CHU Nice, Ctr Memoire Ressources & Rech, INSERM JE Neurobiol & Psychopathol 2441, F-06202 Nice, France
Andrieu, S:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Univ Toulouse III Paul Sabatier, F-31000 Toulouse, France
CHU Toulouse, Dept Publ Hlth, Toulouse, France
Rolland, Y:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Touchon, J:
Univ Hosp Montpellier, Dept Neurol, Montpellier, France
Fitten, JL:
Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
GLA VA Healthcare Syst, Los Angeles, CA USA
Vellas, B:
Ctr Hosp Univ Toulouse, Gerontopole, Toulouse, France
Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France
Univ Toulouse III Paul Sabatier, F-31000 Toulouse, France
Green Accepted
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