Observational study on the efficacy of adalimumab for the treatment of ulcerative colitis and predictors of outcome
Por:
Garcia-Bosch, O, Gisbert, JP, Canas-Ventura, A, Merino, O, Cabriada, JL, Garcia-Sanchez, V, Gutierrez, A, Nos, P, Penalva, M, Hinojosa, J, Garcia-Planella, E, Munoz, F, Calvet, X, Panes, J
Publicada:
1 oct 2013
Resumen:
Background: Information on efficacy and predictors of response to adalimumab in ulcerative colitis (UC) clinical practice is limited.
Aim: Assessment of response to adalimumab and its predictors in an observational cohort study.
Methods: Retrospective cohort study based on data obtained from ENEIDA registry. All patients diagnosed with UC treated with adalimumab were included. Response to adalimumab was evaluated at weeks 12, 28, and 54 according to the partial Mayo score, and requirement of colectomy until end of follow-up.
Results: 48 patients with UC treated with adalimumab were included; 39 (81.3%) had previously received infliximab. Response rates at weeks 12, 28 and 54 were 70.8%, 43.2% and 35% respectively. Response to prior treatment with infliximab was the only predictive factor of response to adalimumab at week 12, which was obtained in 90% of infliximab remitters, 53.8% of responders and 33.3% of primary non-responders (p = 0.01).
Colectomy was required in 11 patients (22.9%), after a mean time of 205 days. The only clinical independent predictor of colectomy was non-response to adalimumab at week 12: colectomy rates were 5/34 (14.7%) in responders and 6/14 (42.9%) in non-responders (p = 0.035), time free of colectomy was significantly reduced in non-responders (p=0.01). Adalimumab withdrawal due to adverse events occurred in 4.2% of patients.
Conclusion: This study shows that adalimumab is an effective treatment in patients with UC. If used as a second anti-TNF, previous achievement of remission with the first anti-TNF predicts response, and failure to achieve response at week 12 predicts colectomy. (C) 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
Filiaciones:
Garcia-Bosch, O:
Hosp Clin Barcelona, Dept Gastroenterol, E-08036 Barcelona, Spain
Gisbert, JP:
Hosp Princesa & IP, Madrid, Spain
Canas-Ventura, A:
Hosp Mar, Barcelona, Spain
Merino, O:
Hosp Cruces, Bizkaia, Spain
Cabriada, JL:
Hosp Galdakano, Bizkaia, Spain
Garcia-Sanchez, V:
Hosp Reina Sofia, Cordoba, Spain
Gutierrez, A:
Hosp Gen Univ, Alicante, Spain
Nos, P:
Hosp La Fe, E-46009 Valencia, Spain
Penalva, M:
Hosp Univ Bellvitge, Barcelona, Spain
Hinojosa, J:
Hosp Manises, Manises, Spain
Garcia-Planella, E:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Munoz, F:
Complejo Hosp Leon, Leon, Spain
Calvet, X:
Hosp Sabadell, Barcelona, Spain
Panes, J:
Hosp Clin Barcelona, Dept Gastroenterol, E-08036 Barcelona, Spain
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