Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

Por: Lambert, JC, Ibrahim-Verbaas, CA, Harold, D, Naj, AC, Sims, R, Bellenguez, C, Jun, G, DeStefano, AL, Bis, JC, Beecham, GW, Grenier-Boley, B, Russo, G, Thornton-Wells, TA, Jones, N, Smith, AV, Chouraki, V, Thomas, C, Ikram, MA, Zelenika, D, Vardarajan, BN, Kamatani, Y, Lin, CF, Gerrish, A, Schmidt, H, Kunkle, B, Dunstan, ML, Ruiz, A, Bihoreau, MT, Choi, SH, Reitz, C, Pasquier, F, Hollingworth, P, Ramirez, A, Hanon, O, Fitzpatrick, AL, Buxbaum, JD, Campion, D, Crane, PK, Baldwin, C, Becker, T, Gudnason, V, Cruchaga, C, Craig, D, Amin, N, Berr, C, Lopez, OL, De Jager, PL, Deramecourt, V, Johnston, JA, Evans, D, Lovestone, S, Letenneur, L, Moron, FJ, Rubinsztein, DC, Eiriksdottir, G, Sleegers, K, Goate, AM, Fievet, N, Huentelman, MJ, Gill, M, Brown, K, Kamboh, MI, Keller, L, Barberger-Gateau, P, McGuinness, B, Larson, EB, Green, R, Myers, AJ, Dufouil, C, Todd, S, Wallon, D, Love, S, Rogaeva, E, Gallacher, J, St George-Hyslop, P, Clarimon, J, Lleo, A, Bayer, A, Tsuang, DW, Yu, L, Tsolaki, M, Bossu, P, Spalletta, G, Proitsi, P, Collinge, J, Sorbi, S, Sanchez-Garcia, F, Fox, NC, Hardy, J, Naranjo, MCD, Bosco, P, Clarke, R, Brayne, C, Galimberti, D, Mancuso, M, Matthews, F, Moebus, S, Mecocci, P, Del Zompo, M, Maier, W, Hampel, H, Pilotto, A, Bullido, M, Panza, F, Caffarra, P, Nacmias, B, Gilbert, JR, Mayhaus, M, Lannfelt, L, Hakonarson, H, Pichler, S, Carrasquillo, MM, Ingelsson, M, Beekly, D, Alvarez, V, Zou, FG, Valladares, O, Younkin, SG, Coto, E, Hamilton-Nelson, KL, Gu, W, Razquin, C, Pastor, P, Mateo, I, Owen, MJ, Faber, KM, Jonsson, PV, Combarros, O, O'Donovan, MC, Cantwell, LB, Soininen, H, Blacker, D, Mead, S, Mosley, TH, Bennett, DA, Harris, TB, Fratiglioni, L, Holmes, C, de Bruijn, RFAG, Passmore, P, Montine, TJ, Bettens, K, Rotter, JI, Brice, A, Morgan, K, Foroud, TM, Kukull, WA, Hannequin, D, Powell, JF, Nalls, MA, Ritchie, K, Lunetta, KL, Kauwe, JSK, Boerwinkle, E, Riemenschneider, M, Boada, M, Hiltunen, M, Martin, ER, Schmidt, R, Rujescu, D, Wang, LS, Dartigues, JF, Mayeux, R, Tzourio, C, Hofman, A, Nothen, MM, Graff, C, Psaty, BM, Jones, L, Haines, JL, Holmans, PA, Lathrop, M, Pericak-Vance, MA, Launer, LJ, Farrer, LA, van Duijn, CM, Van Broeckhoven, C, Moskvina, V, Seshadri, S, Williams, J, Schellenberg, GD, Amouyel, P

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Publicada: 1 dic 2013

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Filiaciones:
Lambert, JC:
 INSERM, U744, F-59045 Lille, France

 Univ Lille 2, Lille, France

 Inst Pasteur, F-59019 Lille, France

Ibrahim-Verbaas, CA:
 Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

Harold, D:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Naj, AC:
 Univ Penn, Dept Biostat & Epidemiol, Perelman Sch Med, Philadelphia, PA 19104 USA

 Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Philadelphia, PA 19104 USA

Sims, R:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Bellenguez, C:
 INSERM, U744, F-59045 Lille, France

 Univ Lille 2, Lille, France

 Inst Pasteur, F-59019 Lille, France

Jun, G:
 Boston Univ, Sch Publ Hlth, Dept Med Biomed Genet, Boston, MA USA

 Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA

 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

DeStefano, AL:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

Bis, JC:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

Beecham, GW:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

 Univ Miami, Dept Human Genet, Dr John T Macdonald Fdn, Miami, FL USA

Grenier-Boley, B:
 INSERM, U744, F-59045 Lille, France

 Univ Lille 2, Lille, France

 Inst Pasteur, F-59019 Lille, France

Russo, G:
 Univ Zurich, ETH, Funct Genom Ctr Zurich, Zurich, Switzerland

Thornton-Wells, TA:
 Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA

Jones, N:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Smith, AV:
 Univ Iceland, Fac Med, Reykjavik, Iceland

 Iceland Heart Assoc, Kopavogur, Iceland

Chouraki, V:
 INSERM, U744, F-59045 Lille, France

 Univ Lille 2, Lille, France

 Inst Pasteur, F-59019 Lille, France

Thomas, C:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Ikram, MA:
 Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Radiol, Rotterdam, Netherlands

 Netherlands Consortium Hlth Aging, Leiden, Netherlands

Zelenika, D:
 CEA, Inst Genom, Ctr Natl Genotypage, Evry, France

Vardarajan, BN:
 Boston Univ, Sch Publ Hlth, Dept Med Biomed Genet, Boston, MA USA

Kamatani, Y:
 Fdn Jean Dausset, Ctr Etud Polymorphisme Humain, Paris, France

Lin, CF:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA

Gerrish, A:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Schmidt, H:
 Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria

Kunkle, B:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

Dunstan, ML:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Ruiz, A:
 Memory Clin Fundacio Alzheimer Ctr Educ ACF, Inst Catala Neurociencies Aplicades, Barcelona, Spain

Bihoreau, MT:
 CEA, Inst Genom, Ctr Natl Genotypage, Evry, France

Choi, SH:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

Reitz, C:
 Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY USA

 Columbia Univ, Gertrude H Sergievsky Ctr, Dept Neurol, New York, NY 10027 USA

Pasquier, F:
 Univ Lille 2, Lille, France

 Ctr Hosp Reg Univ Lille, CNR MAJ, Lille, France

Hollingworth, P:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Ramirez, A:
 Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany

 Univ Bonn, Inst Human Genet, Bonn, Germany

Hanon, O:
 Univ Paris 05, Broca Hosp, Dept Geriatr, Paris, France

Fitzpatrick, AL:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

 Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

Buxbaum, JD:
 Mt Sinai Sch Med, Dept Neurosci, New York, NY USA

 Mt Sinai Sch Med, Dept Psychiat, New York, NY USA

 Mt Sinai Sch Med, Dept Genet & Genom Sci, New York, NY USA

Campion, D:
 Rouen Univ Hosp, INSERM, CNR MAJ, U1079, Rouen, France

Crane, PK:
 Univ Washington, Dept Med, Seattle, WA USA

Baldwin, C:
 Boston Univ, Sch Publ Hlth, Dept Med Biomed Genet, Boston, MA USA

Becker, T:
 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

 Univ Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany

Gudnason, V:
 Univ Iceland, Fac Med, Reykjavik, Iceland

 Iceland Heart Assoc, Kopavogur, Iceland

Cruchaga, C:
 Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

 Washington Univ, Sch Med, Hope Ctr Program Prot Aggregat & Neurodegenerat, St Louis, MO USA

Craig, D:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland

Amin, N:
 Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

Berr, C:
 Hop La Colombiere, Fac Med, U1061, INSERM, Montpellier, France

Lopez, OL:
 Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

De Jager, PL:
 Brigham & Womens Hosp, Dept Neurol & Psychiat, Inst Neurosci, Program Translat NeuroPsychiat Genom, Boston, MA 02115 USA

 Harvard Univ, Sch Med, Boston, MA USA

 Broad Inst, Program Med & Populat Genet, Boston, MA USA

Deramecourt, V:
 Univ Lille 2, Lille, France

 Ctr Hosp Reg Univ Lille, CNR MAJ, Lille, France

Johnston, JA:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland

Evans, D:
 Rush Univ, Med Ctr, Dept Internal Med, Rush Inst Hlth Aging, Chicago, IL 60612 USA

Lovestone, S:
 Univ London, Kings Coll London, Inst Psychiat, London SW3 6LX, England

Letenneur, L:
 Victor Segalen Univ, INSERM, U897, Bordeaux, France

Moron, FJ:
 Neocodex, Dept Genom Estruct, Seville, Spain

Rubinsztein, DC:
 Univ Cambridge, Cambridge Inst Med Res, Cambridge, England

Eiriksdottir, G:
 Iceland Heart Assoc, Kopavogur, Iceland

Sleegers, K:
 Univ Antwerp VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium

 Univ Antwerp, Neurogenet Lab, Inst Born Bunge, B-2020 Antwerp, Belgium

Goate, AM:
 Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

 Washington Univ, Sch Med, Hope Ctr Program Prot Aggregat & Neurodegenerat, St Louis, MO USA

Fievet, N:
 INSERM, U744, F-59045 Lille, France

 Inst Pasteur, F-59019 Lille, France

Huentelman, MJ:
 Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ USA

Gill, M:
 St James Hosp, Mercers Inst Res Aging, Dublin 8, Ireland

 Univ Dublin Trinity Coll, Dublin 2, Ireland

Brown, K:
 Univ Nottingham, Inst Genet, Queens Med Ctr, Nottingham NG7 2RD, England

Kamboh, MI:
 Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA

 Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA USA

Keller, L:
 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

 Stockholm Univ, S-10691 Stockholm, Sweden

Barberger-Gateau, P:
 Victor Segalen Univ, INSERM, U897, Bordeaux, France

McGuinness, B:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland

Larson, EB:
 Univ Washington, Dept Med, Seattle, WA USA

 Grp Hlth, Grp Hlth Res Inst, Seattle, WA USA

Green, R:
 Harvard Univ, Sch Med, Boston, MA USA

 Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

 Brigham & Womens Hosp, Div Genet, Partners Ctr Personalized Genet Med, Boston, MA 02115 USA

Myers, AJ:
 Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

Dufouil, C:
 Victor Segalen Univ, INSERM, U897, Bordeaux, France

Todd, S:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland

Wallon, D:
 Rouen Univ Hosp, INSERM, CNR MAJ, U1079, Rouen, France

Love, S:
 Univ Bristol, Inst Clin Neurosci, Sch Clin Sci, Frenchay Hosp, Bristol, Avon, England

Rogaeva, E:
 Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

Gallacher, J:
 Cardiff Univ, Neuadd Meirionnydd, Univ Wales Hosp, Inst Primary Care & Publ Hlth, Cardiff CF10 3AX, S Glam, Wales

St George-Hyslop, P:
 Univ Cambridge, Cambridge Inst Med Res, Cambridge, England

 Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada

 Univ Cambridge, Dept Clin Neurosci, Cambridge, England

Clarimon, J:
 Univ Autonoma Barcelona, Dept Neurol, Biomed Res Inst Sant Pau IIB Sant Pau, St Pau Hosp, E-08193 Barcelona, Spain

 Ctr Networker Biomed Res Neurodegenerat Dis, Barcelona, Spain

Lleo, A:
 Univ Autonoma Barcelona, Dept Neurol, Biomed Res Inst Sant Pau IIB Sant Pau, St Pau Hosp, E-08193 Barcelona, Spain

 Ctr Networker Biomed Res Neurodegenerat Dis, Barcelona, Spain

Bayer, A:
 Cardiff Univ, Neuadd Meirionnydd, Univ Wales Hosp, Inst Primary Care & Publ Hlth, Cardiff CF10 3AX, S Glam, Wales

Tsuang, DW:
 Vet Adm Puget Sound Hlth Care Syst, GRECC, Seattle, WA USA

Yu, L:
 Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

Tsolaki, M:
 Aristotle Univ Thessaloniki, Dept Neurol, GR-54006 Thessaloniki, Greece

Bossu, P:
 Fdn Santa Lucia, Rome, Italy

Spalletta, G:
 Fdn Santa Lucia, Rome, Italy

Proitsi, P:
 Univ London, Kings Coll London, Inst Psychiat, London SW3 6LX, England

Collinge, J:
 UCL, Inst Neurol, MRC, Pr Unit,Dept Neurodegenerat Dis, London, England

Sorbi, S:
 Univ Florence, NEUROFARBA Dept Neurosci Psychol Drug Res & Child, Florence, Italy

 Univ Florence, Ctr Ric Trasferimento Alta Formaz DENOTH, Florence, Italy

Sanchez-Garcia, F:
 Hosp Univ Dr Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain

Fox, NC:
 UCL, Dementia Res Ctr, Dept Neurodegenerat Dis, Inst Neurol, London, England

Hardy, J:
 Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England

 Inst Neurol, Reta Lilla Weston Labs, London WC1N 3BG, England

Naranjo, MCD:
 Hosp Univ Dr Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain

Bosco, P:
 Assoc Oasi Maria Santissima Srl, IRCCS, Troina, Italy

Clarke, R:
 Univ Oxford, Clin Trial Serv Unit, OHAP, Oxford, England

Brayne, C:
 Univ Cambridge, Inst Publ Hlth, Cambridge, England

Galimberti, D:
 Univ Milan, Fdn Ca Granda, IRCCS Osped Policlin, Milan, Italy

Mancuso, M:
 Univ Pisa, Neurol Clin, Pisa, Italy

Matthews, F:
 MRC, Biostat Unit, Cambridge CB2 2BW, England

Moebus, S:
 Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany

Mecocci, P:
 Univ Perugia, Sect Gerontol & Geriatr, Dept Clin & Expt Med, I-06100 Perugia, Italy

Del Zompo, M:
 Univ Cagliari, Sect Neurosci & Clin Pharmacol, Dept Biomed Sci, Cagliari, Italy

Maier, W:
 Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany

 German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

Hampel, H:
 Goethe Univ Frankfurt, Dept Psychiat, D-60054 Frankfurt, Germany

 Univ Munich, Dept Psychiat, D-80539 Munich, Germany

Pilotto, A:
 IRCCS Casa Sollievo Sofferenza, Gerontol & Geriatr Res Lab, San Giovanni Rotondo, Italy

Bullido, M:
 Univ Autonoma Madrid, Consejo Super Invest Cient, Ctr Biol Mol Severo Ochoa, Madrid, Spain

 Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

 Inst Invest Sanitaria Hosp Paz IdIPaz, Madrid, Spain

Panza, F:
 Univ Bari, Dept Geriatr, Ctr Aging Brain, Bari, Italy

Caffarra, P:
 Univ Parma, Dept Neurosci, I-43100 Parma, Italy

 AUSL, Ctr Cognit Disorders, Parma, Italy

Nacmias, B:
 Univ Florence, NEUROFARBA Dept Neurosci Psychol Drug Res & Child, Florence, Italy

 Univ Florence, Ctr Ric Trasferimento Alta Formaz DENOTH, Florence, Italy

Gilbert, JR:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

 Univ Miami, Dept Human Genet, Dr John T Macdonald Fdn, Miami, FL USA

Mayhaus, M:
 Saarland Univ Hosp, Dept Psychiat, Homburg, Germany

Lannfelt, L:
 Uppsala Univ, Dept Publ Health Geriatr, Uppsala, Sweden

Hakonarson, H:
 Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

Pichler, S:
 Saarland Univ Hosp, Dept Psychiat, Homburg, Germany

Carrasquillo, MM:
 Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

Ingelsson, M:
 Uppsala Univ, Dept Publ Health Geriatr, Uppsala, Sweden

Beekly, D:
 Univ Washington, Natl Alzheimers Coordinating Ctr, Seattle, WA 98195 USA

Alvarez, V:
 Hosp Univ Cent Asturias, Oviedo, Spain

Zou, FG:
 Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

Valladares, O:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA

Younkin, SG:
 Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

Coto, E:
 Hosp Univ Cent Asturias, Oviedo, Spain

Hamilton-Nelson, KL:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

Gu, W:
 Saarland Univ Hosp, Dept Psychiat, Homburg, Germany

Razquin, C:
 Univ Navarra, Ctr Appl Med Res, Sch Med, Neurogenet Lab,Div Neurosci, E-31080 Pamplona, Spain

Pastor, P:
 Univ Navarra, Ctr Appl Med Res, Sch Med, Neurogenet Lab,Div Neurosci, E-31080 Pamplona, Spain

 Inst Salud Carlos III, CIBERNED, Madrid, Spain

Mateo, I:
 Univ Cantabria, Neurol Serv, Marques de Valdecilla Univ Hosp, E-39005 Santander, Spain

 Inst Formac & Invest Marques Valdecilla IFIMAV, Santander, Spain

 Univ Cantabria, Marques de Valdecilla Univ Hosp, CIBERNED, E-39005 Santander, Spain

 IFIMAV, Santander, Spain

Owen, MJ:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Faber, KM:
 Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46204 USA

Jonsson, PV:
 Univ Iceland, Fac Med, Reykjavik, Iceland

 Landspitali Univ Hosp, Geriatr Dept, Reykjavik, Iceland

Combarros, O:
 Univ Cantabria, Neurol Serv, Marques de Valdecilla Univ Hosp, E-39005 Santander, Spain

 Inst Formac & Invest Marques Valdecilla IFIMAV, Santander, Spain

 Univ Cantabria, Marques de Valdecilla Univ Hosp, CIBERNED, E-39005 Santander, Spain

 IFIMAV, Santander, Spain

O'Donovan, MC:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Cantwell, LB:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA

Soininen, H:
 Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

 Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland

Blacker, D:
 Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA USA

Mead, S:
 UCL, Inst Neurol, MRC, Pr Unit,Dept Neurodegenerat Dis, London, England

Mosley, TH:
 Univ Mississippi, Med Ctr, Dept Med Geriatr, Jackson, MS 39216 USA

Bennett, DA:
 Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

 Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

Harris, TB:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

Fratiglioni, L:
 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

 Stockholm Univ, S-10691 Stockholm, Sweden

 Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Stockholm, Sweden

Holmes, C:
 Univ Southampton, Sch Med, Div Clin Neurosci, Southampton, Hants, England

de Bruijn, RFAG:
 Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

 Netherlands Consortium Hlth Aging, Leiden, Netherlands

Passmore, P:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast, Antrim, North Ireland

Montine, TJ:
 Univ Washington, Dept Pathol, Seattle, WA 98195 USA

Bettens, K:
 Univ Antwerp VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium

 Univ Antwerp, Neurogenet Lab, Inst Born Bunge, B-2020 Antwerp, Belgium

Rotter, JI:
 Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

Brice, A:
 Univ Paris 06, Inst Cerveau & Moelle Epiniere CRICM, INSERM, UMRS 975,CNRS,UMR 7225,Ctr Rech,Hosp La Salpetrie, Paris, France

 Hop La Pitie Salpetriere, AP HP, Paris, France

Morgan, K:
 Univ Nottingham, Inst Genet, Queens Med Ctr, Nottingham NG7 2RD, England

Foroud, TM:
 Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46204 USA

Kukull, WA:
 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

Hannequin, D:
 Rouen Univ Hosp, INSERM, CNR MAJ, U1079, Rouen, France

Powell, JF:
 Univ London, Kings Coll London, Inst Psychiat, London SW3 6LX, England

Nalls, MA:
 NIA, Neurogenet Lab, Intramural Res Program, Bethesda, MD 20892 USA

Ritchie, K:
 Hop La Colombiere, Fac Med, U1061, INSERM, Montpellier, France

 Univ London Imperial Coll Sci Technol & Med, Fac Med, St Marys Hosp, London, England

Lunetta, KL:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

Kauwe, JSK:
 Brigham Young Univ, Dept Biol, Provo, UT 84602 USA

Boerwinkle, E:
 Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

 Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA

 Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Houston, TX 77030 USA

Riemenschneider, M:
 Saarland Univ Hosp, Dept Psychiat, Homburg, Germany

Boada, M:
 Memory Clin Fundacio Alzheimer Ctr Educ ACF, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Autonoma Barcelona VHIR UAB, Hosp Univ Vall dHebron, Inst Recerca, Barcelona, Spain

Hiltunen, M:
 Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

 Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland

Martin, ER:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

 Univ Miami, Dept Human Genet, Dr John T Macdonald Fdn, Miami, FL USA

Schmidt, R:
 Med Univ Graz, Dept Neurol, Graz, Austria

Rujescu, D:
 Univ Halle, Dept Psychiat, Halle, Germany

Wang, LS:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA

Dartigues, JF:
 Victor Segalen Univ, INSERM, U897, Bordeaux, France

 CHU Bordeaux, Ctr Memoire Ressources & Rech Bordeaux, Bordeaux, France

Mayeux, R:
 Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY USA

 Columbia Univ, Gertrude H Sergievsky Ctr, Dept Neurol, New York, NY 10027 USA

Tzourio, C:
 Victor Segalen Univ, INSERM, U708, Bordeaux, France

Hofman, A:
 Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

 Netherlands Consortium Hlth Aging, Leiden, Netherlands

Nothen, MM:
 Univ Bonn, Inst Human Genet, Dept Genom, Life & Brain Ctr, Bonn, Germany

Graff, C:
 Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

 Karolinska Inst, Dept Neurobiol, Alzheimers Dis Res Ctr, Stockholm, Sweden

Psaty, BM:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

 Grp Hlth, Grp Hlth Res Inst, Seattle, WA USA

 Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

Jones, L:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Haines, JL:
 Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA

 Vanderbilt Univ, Vanderbilt Ctr Human Genet Res, Nashville, TN 37235 USA

Holmans, PA:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Lathrop, M:
 CEA, Inst Genom, Ctr Natl Genotypage, Evry, France

 Fdn Jean Dausset, Ctr Etud Polymorphisme Humain, Paris, France

 McGill Univ, Montreal, PQ, Canada

 Genome Quebec Innovat Ctr, Montreal, PQ, Canada

Pericak-Vance, MA:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

 Univ Miami, Dept Human Genet, Dr John T Macdonald Fdn, Miami, FL USA

Launer, LJ:
 NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, Bethesda, MD 20892 USA

Farrer, LA:
 Boston Univ, Sch Publ Hlth, Dept Med Biomed Genet, Boston, MA USA

 Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA

 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

 Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

van Duijn, CM:
 Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

 Netherlands Consortium Hlth Aging, Leiden, Netherlands

 Ctr Med Syst Biol, Leiden, Netherlands

Van Broeckhoven, C:
 Univ Antwerp VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium

 Univ Antwerp, Neurogenet Lab, Inst Born Bunge, B-2020 Antwerp, Belgium

Moskvina, V:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Seshadri, S:
 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

Williams, J:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, MRC, Ctr Neuropsychiat Genet & Genom, Cardiff CF10 3AX, S Glam, Wales

Schellenberg, GD:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA USA

Amouyel, P:
 INSERM, U744, F-59045 Lille, France

 Univ Lille 2, Lille, France

 Inst Pasteur, F-59019 Lille, France

 Ctr Hosp Reg Univ Lille, CNR MAJ, Lille, France

 Ctr Hosp Reg Univ Lille, Lille, France