Mapping CushingQOL scores to EQ-5D utility values using data from the European Registry on Cushing's syndrome (ERCUSYN)
Por:
Badia, X, Roset, M, Valassi, E, Franz, H, Forsythe, A, Webb, SM
Publicada:
1 dic 2013
Resumen:
Purpose To construct a model to predict preference-adjusted EuroQol 5D (EQ-5D) health utilities for CS using the disease-specific health-related quality of life measure (CushingQOL).
Methods Data were obtained from the European Registry on CS (ERCUSYN). ERCUSYN is a web-based, multicenter, observational study that enrolled 508 CS patients from 36 centers in 23 European countries. Patients included in the study completed both the EQ-5D and the disease-specific CushingQOL questionnaire. Socio-demographic and clinical data were also collected. The UK tariff values were used to calculate EQ-5D utility scores. Various predictive models were tested, and the final model was selected based on four criteria: explanatory power (adjusted R-squared), consistency of estimated coefficients (sign and parameter estimation), normality of prediction errors (mean error, mean absolute error, root mean squared error), and parsimony.
Results For the mapping analysis, data were available from a total of 129 patients. Mean (SD) age was 43.1 (13) years, and the sample was predominantly female (84.5 %). Patients had a mean (SD) CushingQOL score of 39.7 (17.1) and a mean (SD) 'tariff' value on the EQ-5D of 0.55 (0.3). The model which best met the criteria for selection included the intercept and 3 CushingQOL's questions and had an R-2 of 0.506 and a root mean square error of 0.216.
Conclusions It was possible to find a mapping function which successfully predicted the EQ-5D UK utilities from disease-specific CushingQOL scores. The function may be useful in calculating EQ-5D scores when EQ-5D data have not been gathered directly in a study.
Filiaciones:
Badia, X:
IMS Hlth, Hlth Econ & Outcomes Res, Barcelona 08034, Spain
Roset, M:
IMS Hlth, Hlth Econ & Outcomes Res, Barcelona 08034, Spain
Valassi, E:
Univ Autonoma Barcelona, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Endocrinol Med Dept, Hosp St Pau,IIB St Pau,Unit 747,ISCIII, E-08193 Barcelona, Spain
Franz, H:
Lohmann & Birkner Hlth Care Consulting GmbH, Berlin, Germany
Forsythe, A:
Novartis Oncol, Global Hlth Econ & Market Access, E Hanover, NJ 07936 USA
Webb, SM:
Univ Autonoma Barcelona, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Endocrinol Med Dept, Hosp St Pau,IIB St Pau,Unit 747,ISCIII, E-08193 Barcelona, Spain
Green Published, Hybrid Gold
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