Transcranial diffuse optical monitoring of microvascular cerebral hemodynamics after thrombolysis in ischemic stroke
Por:
Zirak, P, Delgado-Mederos, R, Dinia, L, Carrera, D, Marti-Fabregas, J, Durduran, T
Publicada:
1 ene 2014
Resumen:
The ultimate goal of therapeutic strategies for ischemic stroke is to reestablish the blood flow to the ischemic region of the brain. However, currently, the local cerebral hemodynamics (microvascular) is almost entirely inaccessible for stroke clinicians at the patient bed-side, and the recanalization of the major cerebral arteries (macrovascular) is the only available measure to evaluate the therapy, which does not always reflect the local conditions. Here we report the case of an ischemic stroke patient whose microvascular cerebral blood flow and oxygenation were monitored by a compact hybrid diffuse optical monitor during thrombolytic therapy. This monitor combined diffuse correlation spectroscopy and near-infrared spectroscopy. The reperfusion assessed by hybrid diffuse optics temporally correlated with the recanalization of the middle cerebral artery (assessed by transcranial-Doppler) and was in agreement with the patient outcome. This study suggests that upon further investigation, diffuse optics might have a potential for bed-side acute stroke monitoring and therapy guidance by providing hemodynamics information at the microvascular level. (C) The Authors.
Filiaciones:
Zirak, P:
ICFO Inst Ciencies Foton, Barcelona 08860, Spain
Delgado-Mederos, R:
Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona 08025, Spain
Dinia, L:
Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona 08025, Spain
Carrera, D:
Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona 08025, Spain
Marti-Fabregas, J:
Biomed Res Inst St Pau IIB St Pau, Dept Neurol, Stroke Unit, Barcelona 08025, Spain
Durduran, T:
ICFO Inst Ciencies Foton, Barcelona 08860, Spain
Hybrid Gold
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