DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in BRCA1 and BRCA2 Mutation Carriers
Por:
Osorio, A, Milne, RL, Kuchenbaecker, K, Vaclova, T, Pita, G, Alonso, R, Peterlongo, P, Blanco, I, de la Hoya, M, Duran, M, Diez, O, Cajal, TRY, Konstantopoulou, I, Martinez-Bouzas, C, Conejero, RA, Soucy, P, McGuffog, L, Barrowdale, D, Lee, A, Arver, B, Rantala, J, Loman, N, Ehrencrona, H, Olopade, OI, Beattie, MS, Domchek, SM, Nathanson, K, Rebbeck, TR, Arun, BK, Karlan, BY, Walsh, C, Lester, J, John, EM, Whittemore, AS, Daly, MB, Southey, M, Hopper, J, Terry, MB, Buys, SS, Janavicius, R, Dorfling, CM, van Rensburg, EJ, Steele, L, Neuhausen, SL, Ding, YC, Hansen, TVO, Jonson, L, Ejlertsen, B, Gerdes, AM, Infante, M, Herraez, B, Moreno, LT, Weitzel, JN, Herzog, J, Weeman, K, Manoukian, S, Peissel, B, Zaffaroni, D, Scuvera, G, Bonanni, B, Mariette, F, Volorio, S, Viel, A, Varesco, L, Papi, L, Ottini, L, Tibiletti, MG, Radice, P, Yannoukakos, D, Garber, J, Ellis, S, Frost, D, Platte, R, Fineberg, E, Evans, G, Lalloo, F, Izatt, L, Eeles, R, Adlard, J, Davidson, R, Cole, T, Eccles, D, Cook, J, Hodgson, S, Brewer, C, Tischkowitz, M, Douglas, F, Porteous, M, Side, L, Walker, L, Morrison, P, Donaldson, A, Kennedy, J, Foo, C, Godwin, AK, Schmutzler, RK, Wappenschmidt, B, Rhiem, K, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Plendl, HJ, Niederacher, D, Sutter, C, Wang-Gohrke, S, Steinemann, D, Preisler-Adams, S, Kast, K, Varon-Mateeva, R, Gehrig, A, Stoppa-Lyonnet, D, Sinilnikova, OM, Mazoyer, S, Damiola, F, Poppe, B, Claes, K, Piedmonte, M, Tucker, K, Backes, F, Rodriguez, G, Brewster, W, Wakeley, K, Rutherford, T, Caldes, T, Nevanlinna, H, Aittomaki, K, Rookus, MA, van Os, TAM, van der Kolk, L, de Lange, JL, Meijers-Heijboer, HEJ, van der Hout, AH, van Asperen, CJ, Garcia, EBG, Hoogerbrugge, N, Collee, JM, van Deurzen, CHM, van der Luijt, RB, Devilee, P, Olah, E, Lazaro, C, Teule, A, Menendez, M, Jakubowska, A, Cybulski, C, Gronwald, J, Lubinski, J, Durda, K, Jaworska-Bieniek, K, Johannsson, OT, Maugard, C, Montagna, M, Tognazzo, S, Teixeira, MR, Healey, S, Olswold, C, Guidugli, L, Lindor, N, Slager, S, Szabo, CI, Vijai, J, Robson, M, Kauff, N, Zhang, LY, Rau-Murthy, R, Fink-Retter, A, Singer, CF, Rappaport, C, Kaulich, DG, Pfeiler, G, Tea, MK, Berger, A, Phelan, CM, Greene, MH, Mai, PL, Lejbkowicz, F, Andrulis, I, Mulligan, AM, Glendon, G, Toland, AE, Bojesen, A, Pedersen, IS, Sunde, L, Thomassen, M, Kruse, TA, Jensen, UB, Friedman, E, Laitman, Y, Shimon, SP, Simard, J, Easton, DF, Offit, K, Couch, FJ, Chenevix-Trench, G, Antoniou, AC, Benitez, J
Publicada:
1 abr 2014
Resumen:
Single Nucleotide Polymorphisms (SNPs) in genes involved in the DNA Base Excision Repair (BER) pathway could be associated with cancer risk in carriers of mutations in the high-penetrance susceptibility genes BRCA1 and BRCA2, given the relation of synthetic lethality that exists between one of the components of the BER pathway, PARP1 (poly ADP ribose polymerase), and both BRCA1 and BRCA2. In the present study, we have performed a comprehensive analysis of 18 genes involved in BER using a tagging SNP approach in a large series of BRCA1 and BRCA2 mutation carriers. 144 SNPs were analyzed in a two stage study involving 23,463 carriers from the CIMBA consortium (the Consortium of Investigators of Modifiers of BRCA1 and BRCA2). Eleven SNPs showed evidence of association with breast and/or ovarian cancer at p<0.05 in the combined analysis. Four of the five genes for which strongest evidence of association was observed were DNA glycosylases. The strongest evidence was for rs1466785 in the NEIL2 (endonuclease VIII-like 2) gene (HR: 1.09, 95% CI (1.03-1.16), p = 2.7x10(-3)) for association with breast cancer risk in BRCA2 mutation carriers, and rs2304277 in the OGG1 (8-guanine DNA glycosylase) gene, with ovarian cancer risk in BRCA1 mutation carriers (HR: 1.12 95% CI: 1.03-1.21, p = 4.8x10(-3)). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied.
Filiaciones:
Osorio, A:
Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Biomed Network Rare Dis CIBERER, Madrid, Spain
Milne, RL:
Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia
Kuchenbaecker, K:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Vaclova, T:
Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Pita, G:
Spanish Natl Canc Ctr CNIO, Genotyping Unit CeGen, Madrid, Spain
Alonso, R:
Spanish Natl Canc Ctr CNIO, Genotyping Unit CeGen, Madrid, Spain
Peterlongo, P:
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Blanco, I:
IDIBELL Catalan Inst Oncol, Hereditary Canc Program, Genet Counseling Unit, Barcelona, Spain
de la Hoya, M:
Hosp Clin San Carlos, Mol Oncol Lab, IdISSC, Madrid, Spain
Duran, M:
Univ Valladolid IBGM UVA, Inst Biol & Mol Genet, Valladolid, Spain
Diez, O:
Univ Hosp Vall dHebron, VHIO, VHIR, Oncogenet Lab, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Cajal, TRY:
Hosp Santa Creu & Sant Pau, Oncol Serv, Barcelona, Spain
Konstantopoulou, I:
Natl Ctr Sci Res Demokritos Aghia Paraskevi Attik, Mol Diagnost Lab IRRP, Athens, Greece
Martinez-Bouzas, C:
Cruces Hosp Barakaldo, Dept Biochem, Mol Genet Lab, Bizkaia, Spain
Conejero, RA:
Hosp Clin Lozano Blesa, Med Oncol Serv, Zaragoza, Spain
Soucy, P:
Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada
Univ Laval, Quebec City, PQ, Canada
McGuffog, L:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Barrowdale, D:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Lee, A:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Arver, B:
Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden
Rantala, J:
Karolinska Univ Hosp, Dept Clin Genet, Stockholm, Sweden
Loman, N:
Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
Ehrencrona, H:
Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden
Olopade, OI:
Univ Chicago, Med Ctr, Ctr Clin Canc Genet & Global Hlth, Chicago, IL 60637 USA
Beattie, MS:
Univ Calif San Francisco, Dept Med, San Francisco, CA USA
Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA USA
Univ Calif San Francisco, Dept Biostat, San Francisco, CA USA
Domchek, SM:
Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
Nathanson, K:
Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA
Rebbeck, TR:
Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Arun, BK:
Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
Karlan, BY:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA
Walsh, C:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA
Lester, J:
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Womens Canc Program, Los Angeles, CA 90048 USA
John, EM:
Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA
Whittemore, AS:
Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA
Daly, MB:
Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Southey, M:
Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3052, Australia
Hopper, J:
Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia
Terry, MB:
Columbia Univ, Dept Epidemiol, New York, NY USA
Buys, SS:
Univ Utah, Sch Med, Huntsman Canc Inst, Dept Oncol Sci, Salt Lake City, UT USA
Janavicius, R:
Vilnius Univ Hosp, Santariskiu Clin, Oncol & Transfus Med Ctr, Dept Mol & Regenerat Med, Vilnius, Lithuania
Dorfling, CM:
Univ Pretoria, Dept Genet, ZA-0002 Pretoria, South Africa
van Rensburg, EJ:
Univ Pretoria, Dept Genet, ZA-0002 Pretoria, South Africa
Steele, L:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA
Neuhausen, SL:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA
Ding, YC:
City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Duarte, CA USA
Hansen, TVO:
Univ Copenhagen, Rigshosp, Ctr Genom Med, DK-2100 Copenhagen, Denmark
Jonson, L:
Univ Copenhagen, Rigshosp, Ctr Genom Med, DK-2100 Copenhagen, Denmark
Ejlertsen, B:
Univ Copenhagen, Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark
Gerdes, AM:
Univ Copenhagen, Rigshosp, Dept Clin Genet, DK-2100 Copenhagen, Denmark
Infante, M:
Univ Valladolid IBGM UVA, Inst Biol & Mol Genet, Valladolid, Spain
Herraez, B:
Spanish Natl Canc Ctr CNIO, Genotyping Unit CeGen, Madrid, Spain
Moreno, LT:
Spanish Natl Canc Ctr CNIO, Genotyping Unit CeGen, Madrid, Spain
Weitzel, JN:
City Hope Natl Med Ctr, Clin Canc Genet, Duarte, CA USA
Herzog, J:
City Hope Natl Med Ctr, Clin Canc Genet, Duarte, CA USA
Weeman, K:
City Hope Natl Med Ctr, Clin Canc Genet, Duarte, CA USA
Manoukian, S:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy
Peissel, B:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy
Zaffaroni, D:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy
Scuvera, G:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Med Genet, Milan, Italy
Bonanni, B:
Ist Europeo Oncol, Div Canc Prevent & Genet, Milan, Italy
Mariette, F:
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Cogentech Canc Genet Test Lab, Milan, Italy
Volorio, S:
Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Cogentech Canc Genet Test Lab, Milan, Italy
Viel, A:
IRCCS, Ctr Riferimento Oncol, Div Expt Oncol 1, Aviano, Italy
Varesco, L:
IST Ist Nazl Ric Cancro, IRCCS AOU San Martino, Dept Epidemiol Prevent & Special Funct, Unit Hereditary Canc, Genoa, Italy
Papi, L:
Univ Florence, Dept Biomed Expt & Clin Sci, Unit Med Genet, Florence, Italy
Ottini, L:
Univ Roma La Sapienza, Dept Mol Med, I-00185 Rome, Italy
Tibiletti, MG:
Osped Circolo Univ Insubria, UO Anat Patol, Varese, Italy
Radice, P:
Fdn IRCCS Ist Nazl Tumori INT, Dept Prevent & Predict Med, Unit Mol Bases Genet Risk & Genet Testing, Milan, Italy
Yannoukakos, D:
Natl Ctr Sci Res Demokritos Aghia Paraskevi Attik, Mol Diagnost Lab IRRP, Athens, Greece
Garber, J:
Dana Farber Canc Inst, Boston, MA 02115 USA
Ellis, S:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Frost, D:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Platte, R:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Fineberg, E:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Evans, G:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Lalloo, F:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Izatt, L:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Eeles, R:
Inst Canc Res, Oncogenet Team, London, England
Royal Marsden NHS Fdn Trust, London, England
Adlard, J:
Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England
Davidson, R:
Yorkhill Hosp, Ferguson Smith Ctr Clin Genet, Glasgow, Lanark, Scotland
Cole, T:
Birmingham Womens Hosp Healthcare NHS Trust, West Midlands Reg Genet Serv, Birmingham, W Midlands, England
Eccles, D:
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England
Cook, J:
Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
Hodgson, S:
Univ London, St Georges Hosp, Dept Clin Genet, London, England
Brewer, C:
Royal Devon & Exeter Hosp, Dept Clin Genet, Exeter EX2 5DW, Devon, England
Tischkowitz, M:
Addenbrookes Hosp, East Anglian Reg Genet Serv, Dept Clin Genet, Cambridge, England
Douglas, F:
Newcastle Upon Tyne Hosp NHS Trust, Ctr Life, Inst Human Genet, Newcastle Upon Tyne, Tyne & Wear, England
Porteous, M:
Western Gen Hosp, South East Scotland Reg Genet Serv, Edinburgh EH4 2XU, Midlothian, Scotland
Side, L:
Great Ormond St Hosp Sick Children, North East Thames Reg Genet Serv, London WC1N 3JH, England
Walker, L:
Churchill Hosp, Oxford Reg Genet Serv, Oxford OX3 7LJ, England
Morrison, P:
Belfast City Hosp, Northern Ireland Reg Genet Ctr, Belfast BT9 7AD, Antrim, North Ireland
Donaldson, A:
South West Reg Genet Serv, Bristol, Avon, England
Kennedy, J:
Univ Dublin Trinity Coll, Acad Unit Clin & Mol Oncol, Dublin 2, Ireland
St James Hosp, Dublin 8, Ireland
Foo, C:
Liverpool Womens NHS Fdn Trust, Cheshire & Merseyside Clin Genet Serv, Liverpool, Merseyside, England
Godwin, AK:
Univ Kansas, Med Ctr, Dept Pathol & Lab Med, Kansas City, KS 66103 USA
Schmutzler, RK:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol CIO, Cologne, Germany
Wappenschmidt, B:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol CIO, Cologne, Germany
Rhiem, K:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Univ Hosp Cologne, Ctr Integrated Oncol CIO, Cologne, Germany
Engel, C:
Univ Leipzig, Inst Med Informat Stat & Epidemiol, D-04109 Leipzig, Germany
Meindl, A:
Tech Univ Munich, Klinikum Rechts Isar, Div Tumor Genet, Dept Obstet & Gynaecol, D-80290 Munich, Germany
Ditsch, N:
Tech Univ Munich, Klinikum Rechts Isar, Div Tumor Genet, Dept Obstet & Gynaecol, D-80290 Munich, Germany
Arnold, N:
Univ Med Ctr Schleswig Holstein, Dept Gynecol & Obstet, Kiel, Germany
Plendl, HJ:
Univ Med Ctr Schleswig Holstein, Inst Human Genet, Kiel, Germany
Niederacher, D:
Univ Dusseldorf, Univ Hosp Dusseldorf, Dept Obstet & Gynaecol, Dusseldorf, Germany
Sutter, C:
Univ Heidelberg Hosp, Dept Human Genet, Inst Human Genet, Heidelberg, Germany
Wang-Gohrke, S:
Univ Hosp Ulm, Dept Obstet & Gynaecol, Ulm, Germany
Steinemann, D:
Hannover Med Sch, Inst Cell & Mol Pathol, Hannover, Germany
Preisler-Adams, S:
Univ Munster, Inst Human Genet, D-48149 Munster, Germany
Kast, K:
Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Obstet & Gynaecol, D-01062 Dresden, Germany
Varon-Mateeva, R:
Charite, Campus Virchov Klinikum, Inst Human Genet, Berlin, Germany
Gehrig, A:
Univ Wurzburg, Dept Med Genet, Inst Human Genet, Ctr Familial Breast & Ovarian Canc, D-97070 Wurzburg, Germany
Stoppa-Lyonnet, D:
Inst Curie, Dept Tumour Biol, Paris, France
Inst Curie, INSERM, U830, Paris, France
Univ Paris 05, Sorbonne Paris Cite, Paris, France
Sinilnikova, OM:
Ctr Leon Berard, Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, F-69373 Lyon, France
Univ Lyon 1, CNRS UMR5286, INSERM U1052, Ctr Rech Cancerol Lyon, F-69365 Lyon, France
Mazoyer, S:
Univ Lyon 1, CNRS UMR5286, INSERM U1052, Ctr Rech Cancerol Lyon, F-69365 Lyon, France
Damiola, F:
Univ Lyon 1, CNRS UMR5286, INSERM U1052, Ctr Rech Cancerol Lyon, F-69365 Lyon, France
Poppe, B:
Univ Ghent, Ctr Med Genet, B-9000 Ghent, Belgium
Claes, K:
Univ Ghent, Ctr Med Genet, B-9000 Ghent, Belgium
Piedmonte, M:
Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA
Tucker, K:
Prince Wales Hosp, Sydney, NSW, Australia
Backes, F:
Ohio State Univ, Columbus Canc Council, Columbus, OH 43210 USA
Rodriguez, G:
NorthShore Univ HealthSyst, Div Gynecol Oncol, Evanston, IL USA
Brewster, W:
NorthShore Univ HealthSyst, Div Gynecol Oncol, Chicago, IL USA
Wakeley, K:
Tufts Med Ctr, Boston, MA USA
Rutherford, T:
Yale Univ, Sch Med, New Haven, CT USA
Caldes, T:
Hosp Clin San Carlos, Mol Oncol Lab, IdISSC, Madrid, Spain
Nevanlinna, H:
Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Univ Helsinki, Cent Hosp, Helsinki, Finland
Aittomaki, K:
Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Univ Helsinki, Cent Hosp, Helsinki, Finland
Rookus, MA:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
van Os, TAM:
Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, NL-1105 AZ Amsterdam, Netherlands
van der Kolk, L:
Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
de Lange, JL:
Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Meijers-Heijboer, HEJ:
Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
van der Hout, AH:
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Vejle Hosp, Dept Clin Genet, Vejle, Denmark
van Asperen, CJ:
Leiden Univ, Med Ctr, Dept Clin Genet, Leiden, Netherlands
Garcia, EBG:
MUMC, Sch Oncol & Dev Biol, Dept Clin Genet, Maastricht, Netherlands
MUMC, Sch Oncol & Dev Biol, GROW, Maastricht, Netherlands
Hoogerbrugge, N:
Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands
Collee, JM:
Erasmus Univ, Med Ctr, Dept Clin Genet, Family Canc Clin, Rotterdam, Netherlands
van Deurzen, CHM:
Erasmus Univ, Med Ctr, Family Canc Clin, Dept Pathol, Rotterdam, Netherlands
van der Luijt, RB:
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Devilee, P:
Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands
Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands
Olah, E:
Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Lazaro, C:
IDIBELL Catalan Inst Oncol, Hereditary Canc Program, Mol Diagnost Unit, Barcelona, Spain
Teule, A:
IDIBELL Catalan Inst Oncol, Hereditary Canc Program, Genet Counseling Unit, Barcelona, Spain
Menendez, M:
IDIBELL Catalan Inst Oncol, Hereditary Canc Program, Mol Diagnost Unit, Barcelona, Spain
Jakubowska, A:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Cybulski, C:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Gronwald, J:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Lubinski, J:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Durda, K:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Jaworska-Bieniek, K:
Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Med Univ Warsaw, Postgrad Sch Mol Med, Warsaw, Poland
Johannsson, OT:
Univ Iceland, Landspitali Univ Hosp, Dept Oncol, Reykjavik, Iceland
Univ Iceland, Fac Med, BMC, Reykjavik, Iceland
Maugard, C:
CHRU Nouvel Hop Civil, Hop Univ Strasbourg, Lab Diagnost Genet, Strasbourg, France
CHRU Nouvel Hop Civil, Hop Univ Strasbourg, Serv Oncohematol, Strasbourg, France
Montagna, M:
Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Tognazzo, S:
Veneto Inst Oncol IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Teixeira, MR:
Portuguese Oncol Inst, Dept Genet, Oporto, Portugal
Univ Porto, Biomed Sci Inst ICBAS, P-4100 Oporto, Portugal
Healey, S:
Queensland Inst Med Res, Dept Genet & Computat Biol, Brisbane, Qld 4006, Australia
Olswold, C:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Guidugli, L:
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Lindor, N:
Mayo Clin, Ctr Individualized Med, Scottsdale, AZ USA
Slager, S:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Szabo, CI:
Univ Delaware, Dept Biol Sci, Ctr Translat Canc Res, Newark, DE USA
Vijai, J:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA
Robson, M:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Kauff, N:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Zhang, LY:
Mem Sloan Kettering Canc Ctr, Diagnost Mol Genet Lab, New York, NY 10021 USA
Rau-Murthy, R:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Fink-Retter, A:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Singer, CF:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Rappaport, C:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Kaulich, DG:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Pfeiler, G:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Tea, MK:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Berger, A:
Med Univ Vienna, Dept OB GYN, Vienna, Austria
Med Univ Vienna, Ctr Comprehens Canc, Vienna, Austria
Phelan, CM:
Univ S Florida, H Lee Moffitt Canc Ctr, Dept Canc Epidemiol, Tampa, FL 33682 USA
Greene, MH:
NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
Mai, PL:
NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
Lejbkowicz, F:
Clalit Natl Israeli Canc Control Ctr, Haifa, Israel
Andrulis, I:
Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
Univ Toronto, Canc Care Ontario, Dept Mol Genet, Toronto, ON, Canada
Univ Toronto, Canc Care Ontario, Dept Lab Med, Toronto, ON, Canada
Univ Toronto, Canc Care Ontario, Dept Pathobiol, Toronto, ON, Canada
Mulligan, AM:
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
Univ Hlth Network, Lab Med Program, Toronto, ON, Canada
Glendon, G:
Mt Sinai Hosp, Ontario Canc Genet Network Samuel Lunenfeld Res I, Toronto, ON M5G 1X5, Canada
Toland, AE:
Ohio State Univ, Ctr Comprehens Canc, Div Human Canc Genet, Dept Internal Med & Mol Virol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Div Human Canc Genet, Dept Immunol, Columbus, OH 43210 USA
Ohio State Univ, Ctr Comprehens Canc, Div Human Canc Genet, Dept Med Genet, Columbus, OH 43210 USA
Bojesen, A:
Vejle Hosp, Dept Clin Genet, Vejle, Denmark
Pedersen, IS:
Aalborg Univ Hosp, Dept Clin Biochem, Sect Mol Diagnost, Aalborg, Denmark
Sunde, L:
Aarhus Univ Hosp, Dept Clin Genet, DK-8000 Aarhus, Denmark
Thomassen, M:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Kruse, TA:
Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Jensen, UB:
Aarhus Univ Hosp, Dept Clin Genet, DK-8000 Aarhus, Denmark
Friedman, E:
Sheba Med Ctr, Tel Aviv, Israel
Laitman, Y:
Sheba Med Ctr, Tel Aviv, Israel
Shimon, SP:
Sheba Med Ctr, Tel Aviv, Israel
Simard, J:
Univ Laval, Quebec City, PQ, Canada
Ctr Hosp Univ Quebec, Canc Genom Lab, Canada Res Chair Oncogenet, Quebec City, PQ, Canada
Easton, DF:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Offit, K:
Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10021 USA
Couch, FJ:
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
Chenevix-Trench, G:
Queensland Inst Med Res, Dept Genet & Computat Biol, Brisbane, Qld 4006, Australia
Antoniou, AC:
Univ Cambridge, Dept Publ Hlth & Primary Care, Ctr Canc Genet Epidemiol, Cambridge, England
Benitez, J:
Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Biomed Network Rare Dis CIBERER, Madrid, Spain
Spanish Natl Canc Ctr CNIO, Genotyping Unit CeGen, Madrid, Spain
Gold, Green Published, Green Accepted
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