Randomized Pilot Study: Effects of an Exercise Programme and Leucine Supplementation in Patients with Cirrhosis
Por:
Roman, E, Torrades, MT, Nadal, MJ, Cardenas, G, Nieto, JC, Vidal, S, Bascunana, H, Juarez, C, Guarner, C, Cordoba, J, Soriano, G
Publicada:
1 ago 2014
Resumen:
Physical exercise could improve functional limitations, muscle mass, and health-related quality of life (HRQoL) in patients with cirrhosis.
The purpose of this study was to evaluate the efficacy and safety of an exercise programme and leucine supplementation to increase exercise capacity, muscle mass, and HRQoL in patients with cirrhosis.
Seventeen outpatients with cirrhosis were randomized to an exercise group (n = 8) or a control group (n = 9) in a pilot study. The programme of moderate exercise was performed for 12 weeks under supervision of a physiotherapist. All patients received oral leucine (10 g/day) during the study. At baseline and at the end of the study, we determined exercise capacity (6-min walk and 2-min step tests), anthropometric measurements, and HRQoL by Short Form-36 (SF-36) questionnaire. We also analyzed safety regarding complications of cirrhosis, liver and renal function, inflammatory response and oxidative stress.
In the exercise group, exercise capacity improved, as shown by the increase in the 6-min walk test from 365 (160-420) to 445 m (250-500) (p = 0.01), and in the 2-min step test (p = 0.02). Lower thigh circumference also increased, from 41 (34-53) to 46 cm (36-56) (p = 0.02), and the domains of SF-36 general health (p = 0.03), vitality (p = 0.01) and social function (p = 0.04) improved significantly. In the control group, no statistically significant changes were observed in any of the parameters. We did not observe complications of cirrhosis in either group during the study.
A programme of moderate physical exercise together with leucine supplements in patients with cirrhosis is safe and improves exercise capacity, leg muscle mass and HRQoL.
Filiaciones:
Roman, E:
Hosp Santa Creu & Sant Pau, Dept Gastroenterol, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Inst Recerca IIB St Pau, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Escola Univ Infermeria EUI St Pau, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra, Cerdanyola Del, Spain
Inst Salud Carlos III, CIBERehd, Madrid, Spain
Torrades, MT:
Hosp Santa Creu & Sant Pau, Dept Phys Med & Rehabil, Barcelona 08041, Spain
Nadal, MJ:
Hosp Santa Creu & Sant Pau, Dept Phys Med & Rehabil, Barcelona 08041, Spain
Cardenas, G:
Hosp Valle De Hebron, Dept Internal Med, Liver Unit, Barcelona, Spain
Nieto, JC:
Hosp Santa Creu & Sant Pau, Inst Recerca IIB St Pau, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra, Cerdanyola Del, Spain
Hosp Santa Creu & Sant Pau, Dept Immunol, Barcelona 08041, Spain
Vidal, S:
Hosp Santa Creu & Sant Pau, Inst Recerca IIB St Pau, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra, Cerdanyola Del, Spain
Hosp Santa Creu & Sant Pau, Dept Immunol, Barcelona 08041, Spain
Bascunana, H:
Hosp Santa Creu & Sant Pau, Dept Phys Med & Rehabil, Barcelona 08041, Spain
Juarez, C:
Hosp Santa Creu & Sant Pau, Inst Recerca IIB St Pau, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Dept Immunol, Barcelona 08041, Spain
Guarner, C:
Hosp Santa Creu & Sant Pau, Dept Gastroenterol, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Inst Recerca IIB St Pau, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra, Cerdanyola Del, Spain
Inst Salud Carlos III, CIBERehd, Madrid, Spain
Cordoba, J:
Univ Autonoma Barcelona, Bellaterra, Cerdanyola Del, Spain
Inst Salud Carlos III, CIBERehd, Madrid, Spain
Hosp Valle De Hebron, Dept Internal Med, Liver Unit, Barcelona, Spain
Soriano, G:
Hosp Santa Creu & Sant Pau, Dept Gastroenterol, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Inst Recerca IIB St Pau, Barcelona 08041, Spain
Univ Autonoma Barcelona, Bellaterra, Cerdanyola Del, Spain
Inst Salud Carlos III, CIBERehd, Madrid, Spain
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