Spanish guidelines for the management of autosomal dominant polycystic kidney disease
Por:
Ars, E, Bernis, C, Fraga, G, Martinez, V, Martins, J, Ortiz, A, Rodriguez-Perez, JC, Sans, L, Torra, R
Publicada:
1 sep 2014
Resumen:
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent cause of genetic renal disease and accounts for 6-10% of patients on renal replacement therapy (RRT). Very few prospective, randomized trials or clinical studies address the diagnosis and management of this relatively frequent disorder. No clinical guidelines are available to date. This is a consensus statement presenting the recommendations of the Spanish Working Group on Inherited Kidney Diseases, which were agreed to following a literature search and discussions. Levels of evidence found were C and D according to the Centre for Evidence-Based Medicine (University of Oxford). The recommendations relate to, among other topics, the use of imaging and genetic diagnosis, management of hypertension, pain, cyst infections and bleeding, extra-renal involvement including polycystic liver disease and cranial aneurysms, management of chronic kidney disease (CKD) and RRT and management of children with ADPKD. Recommendations on specific ADPKD therapies are not provided since no drug has regulatory approval for this indication.
Filiaciones:
Ars, E:
Univ Autonoma Barcelona, Inst Invest Carlos III, Mol Biol Lab, IIB St Pau,REDinREN,Fundacio Puigvert, E-08193 Barcelona, Spain
Bernis, C:
Hosp Princesa, Nephrol Dept, REDinREN, Madrid, Spain
Fraga, G:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, E-08193 Barcelona, Spain
Martinez, V:
Hosp Reina Sofia, Dept Nephrol, Murcia, Spain
Martins, J:
Univ Europea Madrid, Hosp Univ Getafe, Nephrol Dept, Madrid, Spain
Ortiz, A:
Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Nephrol Dept, IRSIN,REDinREN, Madrid, Spain
Rodriguez-Perez, JC:
Univ Las Palmas Gran Canaria, Hosp Univ Gran Canaria Dr Negrin, Nephrol Dept, Las Palmas Gran Canaria, Spain
Sans, L:
Hosp del Mar, Nephrol Dept, REDinREN, Barcelona, Spain
Torra, R:
Univ Autonoma Barcelona, Inst Invest Carlos III, Dept Nephrol, Fundacio Puigvert,IIB St Pau,REDinREN, E-08193 Barcelona, Spain
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