Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study
Por:
Bancroft, EK, Page, EC, Castro, E, Lilja, H, Vickers, A, Sjoberg, D, Assel, M, Foster, CS, Mitchell, G, Drew, K, Maehle, L, Axcrona, K, Evans, DG, Bulman, B, Eccles, D, McBride, D, van Asperen, C, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Selkirk, C, Hulick, PJ, Bojesen, A, Skytte, AB, Lam, J, Taylor, L, Oldenburg, R, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Blanco, I, Salinas, M, Cook, J, Rosario, DJ, Buys, S, Conner, T, Ausems, MG, Ong, KR, Hoffman, J, Domchek, S, Powers, J, Teixeira, MR, Maia, S, Foulkes, WD, Taherian, N, Ruijs, M, Helderman-van den Enden, AT, Izatt, L, Davidson, R, Adank, MA, Walker, L, Schmutzler, R, Tucker, K, Kirk, J, Hodgson, S, Harris, M, Douglas, F, Lindeman, GJ, Zgajnar, J, Tischkowitz, M, Clowes, VE, Susman, R, Cajal, TRY, Patcher, N, Gadea, N, Spigelman, A, van Os, T, Liljegren, A, Side, L, Brewer, C, Brady, AF, Donaldson, A, Stefansdottir, V, Friedman, E, Chen-Shtoyerman, R, Amor, DJ, Copakova, L, Barwell, J, Giri, VN, Murthy, V, Nicolai, N, Teo, SH, Greenhalgh, L, Strom, S, Henderson, A, McGrath, J, Gallagher, D, Aaronson, N, Ardern-Jones, A, Bangma, C, Dearnaley, D, Costello, P, Eyfjord, J, Rothwell, J, Falconer, A, Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Kote-Jarai, Z, Lubinski, J, Axcrona, U, Melia, J, McKinley, J, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Wilson, P, Killick, E, Moss, S, Eeles, RA, Taylor, N, Pope, J, Saya, S, Martin, S, Keating, D, Petelin, L, Murphy, M, Doherty, R, Pratt, S, Murphy, D, Cleeve, L, Miller, C, Stapleton, A, Chong, M, Suthers, G, Tucker, K, Andrews, L, Duffy, J, Millard, R, Ward, R, Williams, R, Stricker, P, Bowman, M, Patel, M, O'Connell, S, Hunt, C, Smyth, C, Frydenberg, M, Shackleton, K, McGaughran, J, Boon, M, Pachter, N, Townshend, S, Schofield, L, Gleeson, M, Scott, R, Burke, J, Patterson, B, Bacic, S, Swindle, P, Aprikian, A, Bojeson, A, Cruger, D, Osther, P, Gerdes, AM, Rhiem, K, Luedtke-Heckenkamp, K, Ochsendorf, N, Fiddike, K, Sarin, R, Awatagiri, K, Ghonge, S, Kowtal, P, Mulgund, G, Bambury, R, Farrell, M, Gallagher, F, Ben-Yehoshua, SJ, Nissani, R, Appelman, Z, Moriel, E, Radice, P, Valdagni, R, Magnani, T, Meng, TH, Yoon, SY, Thong, MK, Kiemeney, B, Van der Luijt, RB, Moller, P, Brennhovd, B, Medvik, H, Hanslien, E, Peixoto, A, Henrique, R, Oliveira, J, Goncalves, N, Araujo, L, Seixas, M, Joao, PS, Nogueira, P, Krajc, M, Vrecar, A, Capella, G, Fisas, D, Balmana, J, Morote, J, Hjalm-Eriksson, M, Ekdahl, KJ, Carlsson, S, Hanson, H, Shanley, S, Goh, C, Wiggins, J, Kohut, K, Van As, N, Thompson, A, Ogden, C, Borley, N, Woodhouse, C, Kumar, P, Mercer, C, Paterson, J, Taylor, A, Newcombe, B, Halliday, D, Stayner, B, Fleming-Brown, D, Brice, G, Homfray, T, Hammond, C, Potter, A, Renton, C, Searle, A, Hill, K, Goodman, S, Garcia, L, Devlin, G, Everest, S, Nadolski, M, Jobson, I, Paez, E, Tomkins, S, Pichert, G, Jacobs, C, Langman, C, Weston, M, Dorkins, H, Melville, A, Kosicka-Slawinska, M, Cummings, C, Kiesel, V, Bartlett, M, Randhawa, K, Ellery, N, Male, A, Simon, K, Rees, K, Compton, C, Tidey, L, Nevitt, L, Ingram, S, Catto, J, Howson, J, Chapman, C, Cole, T, Heaton, T, Burgess, L, Longmuir, M, Watt, C, Duncan, A, Kockelbergh, R, Sattar, A, Kaemba, B, Sidat, Z, Patel, N, Siguake, K, Birt, A, Poultney, U, Umez-Eronini, N, Mom, J, Roberts, G, Woodward, A, Sutton, V, Cornford, P, Treherne, K, Griffiths, J, Cogley, L, Rubinstein, W, Brendler, C, Helfand, B, McGuire, M, Kaul, K, Shevrin, D, Weissman, S, Newlin, A, Vogel, K, Weiss, S, Goldgar, D, Venne, V, Stephenson, R, Dechet, C, Arun, B, Davis, JW, Yamamura, Y, Gross, L
Publicada:
1 sep 2014
Resumen:
Background: Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the use of targeted PCa screening in men with BRCA1/2 mutations.
Objective: To report the first year's screening results for all men at enrolment in the study.
Design, setting and participants: We recruited men aged 40-69 yr with germline BRCA1/2 mutations and a control group of men who have tested negative for a pathogenic BRCA1 or BRCA2 mutation known to be present in their families. All men underwent prostate-specific antigen (PSA) testing at enrolment, and those men with PSA > 3 ng/ml were offered prostate biopsy.
Outcome measurements and statistical analysis: PSA levels, PCa incidence, and tumour characteristics were evaluated. The Fisher exact test was used to compare the number of PCa cases among groups and the differences among disease types.
Results and limitations: We recruited 2481 men (791 BRCA1 carriers, 531 BRCA1 controls; 731 BRCA2 carriers, 428 BRCA2 controls). A total of 199 men (8%) presented with PSA > 3.0 ng/ml, 162 biopsies were performed, and 59 PCas were diagnosed (18 BRCA1 carriers, 10 BRCA1 controls; 24 BRCA2 carriers, 7 BRCA2 controls); 66% of the tumours were classified as intermediate-or high-risk disease. The positive predictive value (PPV) for biopsy using a PSA threshold of 3.0 ng/ml in BRCA2 mutation carriers was 48%-double the PPV reported in population screening studies. A significant difference in detecting intermediate-or high-risk disease was observed in BRCA2 carriers. Ninety-five percent of the men were white, thus the results cannot be generalised to all ethnic groups.
Conclusions: The IMPACT screening network will be useful for targeted PCa screening studies in men with germline genetic risk variants as they are discovered. These preliminary results support the use of targeted PSA screening based on BRCA genotype and show that this screening yields a high proportion of aggressive disease.
Patient summary: In this report, we demonstrate that germline genetic markers can be used to identify men at higher risk of prostate cancer. Targeting screening at these men resulted in the identification of tumours that were more likely to require treatment. (C) 2014 European Association of Urology. Published by Elsevier B. V. All rights reserved.
Filiaciones:
Bancroft, EK:
Royal Marsden NHS Fdn Trust, Canc Genet Unit, London, England
Royal Marsden NHS Fdn Trust, Acad Urol Unit, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
Page, EC:
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
Castro, E:
Inst Canc Res, Oncogenet Team, London, England
Spanish Natl Canc Res Ctr, Madrid, Spain
Inst Canc Res, Coordinating Ctr, London, England
Lilja, H:
Mem Sloan Kettering Canc Ctr, Dept Lab Med, 1275 York Ave, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA
Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA
Univ Oxford, Nuffield Dept Surg Sci, Oxford, England
Univ Tampere, Inst Biomed Technol, Tampere, Finland
Lund Univ, Dept Lab Med, Malmo, Sweden
Vickers, A:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA
Sjoberg, D:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA
Assel, M:
Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA
Foster, CS:
HCA Healthcare Labs, London WC1E 6JA, England
Mitchell, G:
Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic, Australia
Drew, K:
Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Maehle, L:
Norwegian Radium Hosp, Oslo, Norway
Axcrona, K:
Norwegian Radium Hosp, Oslo, Norway
Evans, DG:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Gen Med, Manchester, Lancs, England
Manchester Reg Genet Serv, Manchester, Lancs, England
Bulman, B:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Gen Med, Manchester, Lancs, England
Manchester Reg Genet Serv, Manchester, Lancs, England
Eccles, D:
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England
Wessex Clin Genet Serv, Southampton, Hants, England
McBride, D:
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England
Wessex Clin Genet Serv, Southampton, Hants, England
van Asperen, C:
Leiden Univ Med Ctr, Leiden, Netherlands
Vasen, H:
Fdn Detect Hereditary Tumours, Leiden, Netherlands
Kiemeney, LA:
Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands
Ringelberg, J:
Fdn Detect Hereditary Tumours, Leiden, Netherlands
Cybulski, C:
Pomeranian Med Univ, Intl Hereditary Canc Ctr, Szczecin, Poland
Int Hereditary Canc Ctr, Szczecin, Poland
Wokolorczyk, D:
Pomeranian Med Univ, Intl Hereditary Canc Ctr, Szczecin, Poland
Int Hereditary Canc Ctr, Szczecin, Poland
Selkirk, C:
NorthShore Univ HealthSyst, Ctr Med Genet, Evanston, IL USA
Northshore Univ Healthsyst, Evanston, IL USA
Hulick, PJ:
NorthShore Univ HealthSyst, Ctr Med Genet, Evanston, IL USA
Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA
Northshore Univ Healthsyst, Evanston, IL USA
Bojesen, A:
Vejle Hosp, Vejle, Denmark
Skytte, AB:
Vejle Hosp, Vejle, Denmark
Lam, J:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Taylor, L:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Oldenburg, R:
Erasmus MC, Rotterdam, Netherlands
Cremers, R:
Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands
Verhaegh, G:
Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands
van Zelst-Stams, WA:
Radboud Univ Nijmegen Med Ctr, Nijmegen, Netherlands
Oosterwijk, JC:
Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands
Blanco, I:
LHosp, Catalonian Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Catalonian Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Salinas, M:
LHosp, Catalonian Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Catalonian Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Cook, J:
Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
North Trent Clin Genet Serv, Sheffield, S Yorkshire, England
Rosario, DJ:
Royal Hallamshire Hosp, Sheffield, S Yorkshire, England
Acad Urol Unit, Sheffield, S Yorkshire, England
Buys, S:
Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA
Conner, T:
Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA
Ausems, MG:
Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Univ Med Ctr Utrecht, Utrecht, Netherlands
Ong, KR:
Birmingham Womens Hosp, Clin Genet Unit, Birmingham, W Midlands, England
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Hoffman, J:
Birmingham Womens Hosp, Clin Genet Unit, Birmingham, W Midlands, England
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Domchek, S:
Univ Penn, Basser Res Ctr, Philadelphia, PA 19104 USA
Univ Penn, Philadelphia, PA 19104 USA
Powers, J:
Univ Penn, Basser Res Ctr, Philadelphia, PA 19104 USA
Univ Penn, Philadelphia, PA 19104 USA
Teixeira, MR:
Portuguese Oncol Inst, Genet Dept, Porto, Portugal
Univ Porto, Biomed Sci Inst ICBAS, Porto, Portugal
Portuguese Oncol Inst, Porto, Portugal
Maia, S:
Portuguese Oncol Inst, Genet Dept, Porto, Portugal
Portuguese Oncol Inst, Porto, Portugal
Foulkes, WD:
McGill Univ, Dept Oncol, McGill Program Canc Genet, Montreal, PQ, Canada
McGill Univ, Montreal, PQ, Canada
Taherian, N:
McGill Univ, Dept Oncol, McGill Program Canc Genet, Montreal, PQ, Canada
McGill Univ, Montreal, PQ, Canada
Ruijs, M:
Netherlands Canc Inst, Amsterdam, Netherlands
Helderman-van den Enden, AT:
Maastricht Univ Med Ctr, Dept Clin Genet, Maastricht, Netherlands
Univ Hosp Maastricht, Maastricht, Netherlands
Izatt, L:
South East Thames Genet Serv, London, England
Guys Hosp, London, England
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Davidson, R:
Yorkhill NHS Trust, Duncan Guthrie Inst Med Genet, Glasgow, Lanark, Scotland
West Scotland Genet Serv, Glasgow, Lanark, Scotland
Adank, MA:
Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands
Walker, L:
Churchill Hosp, Oxford, England
Oxford Reg Genet Serv, Oxford, England
Schmutzler, R:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Tucker, K:
Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Univ New S Wales, Fac Med, Sydney, NSW, Australia
Kirk, J:
Westmead Hosp, Familial Canc Serv, Sydney, NSW, Australia
Univ Sydney, Sydney Med Sch, Westmead Millennium Inst, Sydney, NSW, Australia
Hodgson, S:
St George Hosp, London, England
South West Thames Reg Genet Serv, London, England
Harris, M:
Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Douglas, F:
Newcastle Upon Tyne Hosp, No Gen Serv, Newcastle Upon Tyne, Tyne & Wear, England
Northern Clin Genet Serv, Newcastle Upon Tyne, Tyne & Wear, England
Lindeman, GJ:
Royal Melbourne Hosp, Familial Canc Ctr, Parkville, Vic, Australia
Walter & Eliza Hall Inst Med Res, Stem Cells & Canc Div, Parkville, Vic, Australia
Univ Melbourne, Dept Med, Parkville, Vic, Australia
Zgajnar, J:
Inst Oncol, Ljubljana, Slovenia
Tischkowitz, M:
Addenbrookes Hosp, Cambridge, England
Univ Cambridge, Cambridge, England
McGill Univ, Montreal, PQ, Canada
East Anglian Reg Genet Serv, Cambridge, England
Clowes, VE:
Addenbrookes Hosp, Cambridge, England
Univ Cambridge, Cambridge, England
East Anglian Reg Genet Serv, Cambridge, England
North West Thames Reg Genet Serv, Harrow, Middx, England
Susman, R:
Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
Cajal, TRY:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Patcher, N:
King Edward Mem Hosp, Genet Serv WA, Subiaco, WA, Australia
Univ Western Australia, Dept Paediat, Perth, WA, Australia
Gadea, N:
Hosp Valle De Hebron, Barcelona, Spain
Spigelman, A:
Hunter Family Canc Serv, Waratah, NSW, Australia
Univ New South West, St Vincents Clin Sch, Darlinghurst, NSW, Australia
St Vincent Hosp, Kinghorn Canc Ctr, Hereditary Canc Clin, Sydney, NSW, Australia
Univ New S Wales, St Vincents Clin Sch, Sydney, NSW, Australia
van Os, T:
Acad Med Ctr, Amsterdam, Netherlands
Liljegren, A:
Karolinska Univ Hosp, Stockholm, Sweden
Karolinska Inst, Stockholm, Sweden
Side, L:
Inst Child Hlth, NE Thames Reg Gent Serv, London, England
North Eest Thames Reg Genet Serv, NE Thames, England
Brewer, C:
Derriford Hosp, Peninsular Genet, Plymouth, Devon, England
Royal Devon & Exeter Hosp, Exeter, Devon, England
Peninsula Clin Genet Serv, Exeter, Devon, England
Derriford Hosp, Plymouth, Devon, England
Brady, AF:
North West London Hosp NHS Trust, Kennedy Galton Ctr, North West Thames Reg Genet Serv, Harrow, Middx, England
North West Thames Reg Genet Serv, Harrow, Middx, England
Donaldson, A:
St Michaels Hosp, Bristol, Avon, England
South West Reg Genet Serv, Bristol, Avon, England
Stefansdottir, V:
Landspitali Natl Univ Hosp Iceland, Reykjavik, Iceland
Univ Hosp Iceland, Reykjavik, Iceland
Friedman, E:
Chaim Sheba Med Ctr, Tel Hashomer, Israel
Chaim Shema Med Ctr, Tel Hashomer, Israel
Chen-Shtoyerman, R:
Kaplan Med Ctr, Genet Inst, Rehovot, Israel
Kaplan Med Ctr, Dept Urol, Rehovot, Israel
Amor, DJ:
Murdoch Childrens Res Inst, Parkville, Vic, Australia
Univ Melbourne, Dept Paediat, Parkville, Vic, Australia
Copakova, L:
Natl Canc Inst, Bratislava, Slovakia
Barwell, J:
Univ Leicester, Leicester, Leics, England
Univ Hosp Leicester, Leicester, Leics, England
Leicester Royal Infirm, Leicester, Leics, England
Giri, VN:
Fox Chase Canc Ctr, Philadelphia, PA USA
Murthy, V:
Tata Mem Hosp, Bombay, Maharashtra, India
Nicolai, N:
Ist Nazl Tumori, Milan, Italy
Teo, SH:
Subang Jaya Med Ctr, Canc Res Initiat Fdn, Selangor, Darul Ehsan, Malaysia
Univ Malaya, Kuala Lumpur, Malaysia
Greenhalgh, L:
Royal Liverpool Childrens Hosp, Clin Genet, Liverpool, Merseyside, England
Royal Liverpool Childrens Hosp, Liverpool, Merseyside, England
Strom, S:
Univ Texas MD Anderson Canc Ctr, Houston, TX USA
MD Anderson, Houston, TX USA
Henderson, A:
Newcastle Upon Tyne Hosp, No Gen Serv, Newcastle Upon Tyne, Tyne & Wear, England
North Cumbria Univ Hosp Trust, Whitehaven, England
McGrath, J:
Royal Devon & Exeter Hosp, Exeter, Devon, England
Gallagher, D:
Mater Misericordiae Univ Hosp, Dublin, Ireland
Mater Private Hosp, Dublin, Ireland
Aaronson, N:
Netherlands Canc Inst, Amsterdam, Netherlands
Ardern-Jones, A:
Royal Marsden NHS Fdn Trust, Canc Genet Unit, London, England
Royal Marsden NHS Fdn Trust, Acad Urol Unit, London, England
Royal Marsden NHS Fdn Trust, London, England
Bangma, C:
Erasmus MC, Rotterdam, Netherlands
Dearnaley, D:
Royal Marsden NHS Fdn Trust, Canc Genet Unit, London, England
Royal Marsden NHS Fdn Trust, Acad Urol Unit, London, England
Inst Canc Res, Oncogenet Team, London, England
Costello, P:
Princess Anne Hosp, Wessex Clin Genet Serv, Southampton, Hants, England
Wessex Clin Genet Serv, Southampton, Hants, England
Eyfjord, J:
Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland
Rothwell, J:
Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Gen Med, Manchester, Lancs, England
Manchester Reg Genet Serv, Manchester, Lancs, England
Falconer, A:
Imperial Coll Healthcare NHS Trust, London, England
Gronberg, H:
Univ Hosp, Umea, Sweden
Hamdy, FC:
Univ Oxford, Nuffield Dept Surg Sci, Oxford, England
Churchill Hosp, Oxford, England
Johannsson, O:
Landspitali Natl Univ Hosp Iceland, Reykjavik, Iceland
Univ Hosp Iceland, Reykjavik, Iceland
Khoo, V:
Royal Marsden NHS Fdn Trust, Canc Genet Unit, London, England
Royal Marsden NHS Fdn Trust, Acad Urol Unit, London, England
Royal Marsden NHS Fdn Trust, London, England
Kote-Jarai, Z:
Inst Canc Res, Oncogenet Team, London, England
Lubinski, J:
Pomeranian Med Univ, Intl Hereditary Canc Ctr, Szczecin, Poland
Int Hereditary Canc Ctr, Szczecin, Poland
Axcrona, U:
Norwegian Radium Hosp, Oslo, Norway
Melia, J:
Univ Cambridge, Cambridge, England
McKinley, J:
Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Mitra, AV:
Inst Canc Res, Oncogenet Team, London, England
Univ Coll London Hosp NHS Fdn, London, England
Moynihan, C:
Inst Canc Res, Oncogenet Team, London, England
Rennert, G:
Carmel Hosp, CHS Natl Canc Control Ctr, Haifa, Israel
Suri, M:
Nottingham City Hosp, Nottingham, England
Wilson, P:
BioZenix, Altrincham, Cheshire, England
Killick, E:
Royal Marsden NHS Fdn Trust, Canc Genet Unit, London, England
Royal Marsden NHS Fdn Trust, Acad Urol Unit, London, England
Inst Canc Res, Oncogenet Team, London, England
Royal Marsden NHS Fdn Trust, London, England
Eeles, RA:
Royal Marsden NHS Fdn Trust, Canc Genet Unit, London, England
Royal Marsden NHS Fdn Trust, Acad Urol Unit, London, England
Inst Canc Res, Oncogenet Team, London, England
Inst Canc Res, Coordinating Ctr, London, England
Taylor, N:
Inst Canc Res, Coordinating Ctr, London, England
Pope, J:
Inst Canc Res, Coordinating Ctr, London, England
Saya, S:
Inst Canc Res, Coordinating Ctr, London, England
Martin, S:
Inst Canc Res, Coordinating Ctr, London, England
Keating, D:
Inst Canc Res, Coordinating Ctr, London, England
Petelin, L:
Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Murphy, M:
Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Doherty, R:
Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Pratt, S:
Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Murphy, D:
Peter MacCallum Canc Ctr, Dept Urol, Melbourne, Vic, Australia
Cleeve, L:
Peter MacCallum Canc Ctr, Dept Urol, Melbourne, Vic, Australia
Miller, C:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Stapleton, A:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Chong, M:
Repatriat Gen Hosp, Dept Urol, Daw Pk, SA, Australia
Suthers, G:
Womens & Childrens Hosp, SA Pathol, SA Clin Genet Serv, Adelaide, SA, Australia
Tucker, K:
Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Univ New S Wales, Fac Med, Sydney, NSW, Australia
Andrews, L:
Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Duffy, J:
Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW, Australia
Millard, R:
Prince Wales Hosp, Dept Urol, Randwick, NSW, Australia
Ward, R:
UNSW, Fac Med, Prince Wales Clin Sch, Hereditary Canc Clin, Sydney, NSW, Australia
Williams, R:
UNSW, Fac Med, Prince Wales Clin Sch, Hereditary Canc Clin, Sydney, NSW, Australia
Stricker, P:
St Vincents Clin, Sydney, NSW, Australia
Bowman, M:
Westmead Hosp, Familial Canc Serv, Sydney, NSW, Australia
Patel, M:
Westmead Hosp, Sydney, NSW, Australia
O'Connell, S:
Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Hunt, C:
Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Smyth, C:
Monash Hlth, Familial Canc Ctr, Clayton, Vic, Australia
Frydenberg, M:
Monash Med Ctr, Clayton, Vic, Australia
Shackleton, K:
Royal Melbourne Hosp, Familial Canc Ctr, Parkville, Vic, Australia
McGaughran, J:
Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
Boon, M:
Royal Brisbane & Womens Hosp, Genet Hlth Queensland, Herston, Qld, Australia
Townshend, S:
King Edward Mem Hosp, Genet Serv WA, Subiaco, WA, Australia
Schofield, L:
King Edward Mem Hosp, Genet Serv WA, Subiaco, WA, Australia
Gleeson, M:
Hunter Family Canc Serv, Waratah, NSW, Australia
Scott, R:
Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia
Burke, J:
Tasmanian Clin Genet Serv, Hobart, Tas, Australia
Patterson, B:
Tasmanian Clin Genet Serv, Hobart, Tas, Australia
Bacic, S:
Tasmanian Clin Genet Serv, Hobart, Tas, Australia
Swindle, P:
Mater Private Hosp, Brisbane, Qld, Australia
Aprikian, A:
McGill Univ, Montreal, PQ, Canada
Cruger, D:
Vejle Hosp, Vejle, Denmark
Osther, P:
Fredericia & Kolding Hosp, Fredericia, Denmark
Gerdes, AM:
Odense Univ Hosp, Odense, Denmark
Rhiem, K:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Luedtke-Heckenkamp, K:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Ochsendorf, N:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Fiddike, K:
Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Cologne, Germany
Sarin, R:
Tata Mem Hosp, Bombay, Maharashtra, India
Awatagiri, K:
Tata Mem Hosp, Bombay, Maharashtra, India
Ghonge, S:
Tata Mem Hosp, Bombay, Maharashtra, India
Kowtal, P:
Tata Mem Hosp, Bombay, Maharashtra, India
Mulgund, G:
Tata Mem Hosp, Bombay, Maharashtra, India
Bambury, R:
Mater Private Hosp, Dublin, Ireland
Farrell, M:
Mater Private Hosp, Dublin, Ireland
Gallagher, F:
Mater Private Hosp, Dublin, Ireland
Ben-Yehoshua, SJ:
Kaplan Med Ctr, Genet Inst, Rehovot, Israel
Kaplan Med Ctr, Dept Urol, Rehovot, Israel
Nissani, R:
Kaplan Med Ctr, Genet Inst, Rehovot, Israel
Kaplan Med Ctr, Dept Urol, Rehovot, Israel
Appelman, Z:
Kaplan Med Ctr, Genet Inst, Rehovot, Israel
Kaplan Med Ctr, Dept Urol, Rehovot, Israel
Moriel, E:
Kaplan Med Ctr, Genet Inst, Rehovot, Israel
Kaplan Med Ctr, Dept Urol, Rehovot, Israel
Radice, P:
Ist Nazl Tumori, Milan, Italy
Valdagni, R:
Ist Nazl Tumori, Milan, Italy
Magnani, T:
Ist Nazl Tumori, Milan, Italy
Meng, TH:
Subang Jaya Med Ctr, Canc Res Initiat Fdn, Selangor, Darul Ehsan, Malaysia
Yoon, SY:
Subang Jaya Med Ctr, Canc Res Initiat Fdn, Selangor, Darul Ehsan, Malaysia
Thong, MK:
Univ Malaya, Kuala Lumpur, Malaysia
Van der Luijt, RB:
Univ Med Ctr Utrecht, Utrecht, Netherlands
Moller, P:
Norwegian Radium Hosp, Oslo, Norway
Brennhovd, B:
Norwegian Radium Hosp, Oslo, Norway
Medvik, H:
Norwegian Radium Hosp, Oslo, Norway
Hanslien, E:
Norwegian Radium Hosp, Oslo, Norway
Peixoto, A:
Portuguese Oncol Inst, Porto, Portugal
Henrique, R:
Portuguese Oncol Inst, Porto, Portugal
Oliveira, J:
Portuguese Oncol Inst, Porto, Portugal
Goncalves, N:
Portuguese Oncol Inst, Porto, Portugal
Araujo, L:
Portuguese Oncol Inst, Porto, Portugal
Seixas, M:
Portuguese Oncol Inst, Porto, Portugal
Joao, PS:
Portuguese Oncol Inst, Porto, Portugal
Nogueira, P:
Portuguese Oncol Inst, Porto, Portugal
Krajc, M:
Inst Oncol, Ljubljana, Slovenia
Vrecar, A:
Inst Oncol, Ljubljana, Slovenia
Capella, G:
Catalonian Inst Oncol, Hereditary Canc Program, Barcelona, Spain
Fisas, D:
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Balmana, J:
Hosp Valle De Hebron, Barcelona, Spain
Morote, J:
Hosp Valle De Hebron, Barcelona, Spain
Hjalm-Eriksson, M:
Karolinska Univ Hosp, Stockholm, Sweden
Ekdahl, KJ:
Karolinska Univ Hosp, Stockholm, Sweden
Carlsson, S:
Karolinska Univ Hosp, Stockholm, Sweden
Hanson, H:
Royal Marsden NHS Fdn Trust, London, England
Shanley, S:
Royal Marsden NHS Fdn Trust, London, England
Goh, C:
Royal Marsden NHS Fdn Trust, London, England
Wiggins, J:
Royal Marsden NHS Fdn Trust, London, England
Kohut, K:
Royal Marsden NHS Fdn Trust, London, England
Van As, N:
Royal Marsden NHS Fdn Trust, London, England
Thompson, A:
Royal Marsden NHS Fdn Trust, London, England
Ogden, C:
Royal Marsden NHS Fdn Trust, London, England
Borley, N:
Royal Marsden NHS Fdn Trust, London, England
Woodhouse, C:
Royal Marsden NHS Fdn Trust, London, England
Kumar, P:
Royal Marsden NHS Fdn Trust, London, England
Mercer, C:
Wessex Clin Genet Serv, Southampton, Hants, England
Paterson, J:
East Anglian Reg Genet Serv, Cambridge, England
Taylor, A:
East Anglian Reg Genet Serv, Cambridge, England
Newcombe, B:
East Anglian Reg Genet Serv, Cambridge, England
Halliday, D:
Oxford Reg Genet Serv, Oxford, England
Stayner, B:
Oxford Reg Genet Serv, Oxford, England
Fleming-Brown, D:
Oxford Reg Genet Serv, Oxford, England
Brice, G:
South West Thames Reg Genet Serv, London, England
Homfray, T:
South West Thames Reg Genet Serv, London, England
Hammond, C:
South West Thames Reg Genet Serv, London, England
Potter, A:
Peninsula Clin Genet Serv, Exeter, Devon, England
Renton, C:
Peninsula Clin Genet Serv, Exeter, Devon, England
Searle, A:
Peninsula Clin Genet Serv, Exeter, Devon, England
Hill, K:
Peninsula Clin Genet Serv, Exeter, Devon, England
Goodman, S:
Peninsula Clin Genet Serv, Exeter, Devon, England
Garcia, L:
Peninsula Clin Genet Serv, Exeter, Devon, England
Devlin, G:
Peninsula Clin Genet Serv, Exeter, Devon, England
Everest, S:
Peninsula Clin Genet Serv, Exeter, Devon, England
Nadolski, M:
Peninsula Clin Genet Serv, Exeter, Devon, England
Jobson, I:
Northern Clin Genet Serv, Newcastle Upon Tyne, Tyne & Wear, England
Paez, E:
Northern Clin Genet Serv, Newcastle Upon Tyne, Tyne & Wear, England
Tomkins, S:
South West Reg Genet Serv, Bristol, Avon, England
Pichert, G:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Jacobs, C:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Langman, C:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Weston, M:
Guys Hosp London, South East Thames Reg Genet Serv, London, England
Dorkins, H:
North West Thames Reg Genet Serv, Harrow, Middx, England
Melville, A:
North West Thames Reg Genet Serv, Harrow, Middx, England
Kosicka-Slawinska, M:
North West Thames Reg Genet Serv, Harrow, Middx, England
Cummings, C:
North West Thames Reg Genet Serv, Harrow, Middx, England
Kiesel, V:
North West Thames Reg Genet Serv, Harrow, Middx, England
Bartlett, M:
North West Thames Reg Genet Serv, Harrow, Middx, England
Randhawa, K:
North West Thames Reg Genet Serv, Harrow, Middx, England
Ellery, N:
North West Thames Reg Genet Serv, Harrow, Middx, England
Male, A:
North Eest Thames Reg Genet Serv, NE Thames, England
Simon, K:
North Eest Thames Reg Genet Serv, NE Thames, England
Rees, K:
North Eest Thames Reg Genet Serv, NE Thames, England
Compton, C:
North Eest Thames Reg Genet Serv, NE Thames, England
Tidey, L:
North Eest Thames Reg Genet Serv, NE Thames, England
Nevitt, L:
North Trent Clin Genet Serv, Sheffield, S Yorkshire, England
Ingram, S:
North Trent Clin Genet Serv, Sheffield, S Yorkshire, England
Catto, J:
Acad Urol Unit, Sheffield, S Yorkshire, England
Howson, J:
Acad Urol Unit, Sheffield, S Yorkshire, England
Chapman, C:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Cole, T:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Heaton, T:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Burgess, L:
West Midlands Reg Clin Genet Serv, Birmingham, W Midlands, England
Longmuir, M:
West Scotland Genet Serv, Glasgow, Lanark, Scotland
Watt, C:
West Scotland Genet Serv, Glasgow, Lanark, Scotland
Duncan, A:
West Scotland Genet Serv, Glasgow, Lanark, Scotland
Kockelbergh, R:
Leicester Royal Infirm, Leicester, Leics, England
Sattar, A:
Leicester Royal Infirm, Leicester, Leics, England
Kaemba, B:
Leicester Royal Infirm, Leicester, Leics, England
Sidat, Z:
Leicester Royal Infirm, Leicester, Leics, England
Patel, N:
Leicester Royal Infirm, Leicester, Leics, England
Siguake, K:
Leicester Royal Infirm, Leicester, Leics, England
Birt, A:
North Cumbria Univ Hosp Trust, Whitehaven, England
Poultney, U:
North Cumbria Univ Hosp Trust, Whitehaven, England
Umez-Eronini, N:
North Cumbria Univ Hosp Trust, Whitehaven, England
Roberts, G:
Royal Liverpool Childrens Hosp, Liverpool, Merseyside, England
Woodward, A:
Royal Liverpool Childrens Hosp, Liverpool, Merseyside, England
Sutton, V:
North Cumbria Univ Hosp Trust, Whitehaven, England
Royal Liverpool Childrens Hosp, Liverpool, Merseyside, England
Cornford, P:
Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England
Treherne, K:
Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England
Griffiths, J:
Royal Liverpool & Broadgreen Hosp NHS Trust, Liverpool, Merseyside, England
Cogley, L:
Derriford Hosp, Plymouth, Devon, England
Rubinstein, W:
Northshore Univ Healthsyst, Evanston, IL USA
Brendler, C:
Northshore Univ Healthsyst, Evanston, IL USA
Helfand, B:
Northshore Univ Healthsyst, Evanston, IL USA
McGuire, M:
Northshore Univ Healthsyst, Evanston, IL USA
Kaul, K:
Northshore Univ Healthsyst, Evanston, IL USA
Shevrin, D:
Northshore Univ Healthsyst, Evanston, IL USA
Weissman, S:
Northshore Univ Healthsyst, Evanston, IL USA
Newlin, A:
Northshore Univ Healthsyst, Evanston, IL USA
Vogel, K:
Northshore Univ Healthsyst, Evanston, IL USA
Weiss, S:
Northshore Univ Healthsyst, Evanston, IL USA
Arun, B:
MD Anderson, Houston, TX USA
Davis, JW:
MD Anderson, Houston, TX USA
Yamamura, Y:
MD Anderson, Houston, TX USA
Gross, L:
Fox Chase Canc Ctr, Philadelphia, PA USA
Portuguese Oncol Inst, Res Ctr, Porto, Portugal.
McGill Univ, Dept Human Genet, McGill Program Canc Genet, Montreal, PQ, Canada.
Victorian Canc Biobank, Carlton, Vic, Australia.
STOET Stichting Opsporing Erfelijke Tumoren, Leiden, Netherlands.
Green Accepted, Green Published, Hybrid Gold
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