Disease severity in familial cases of IBD
Por:
Andreu, M, Marquez, L, Domenech, E, Gisbert, JP, Garcia, V, Marin-Jimenez, I, Penalva, M, Gomollon, F, Calvet, X, Merino, O, Garcia-Planella, E, Vazquez-Romero, N, Esteve, M, Nos, P, Gutierrez, A, Vera, I, Cabriada, JL, Martin, MD, Canas-Ventura, A, Panes, J
Publicada:
1 mar 2014
Resumen:
Background: Phenotypic traits of familial IBD relative to sporadic cases are controversial, probably related to limited statistical power of published evidence.
Aim: To know if there are phenotype differences between familial and sporadic IBD, evaluating the prospective Spanish registry (ENEIDA) with 11,983 cases.
Methods: 5783 patients (48.3%) had ulcerative colitis (UC) and 6200 (51.7%) Crohn's disease (CD). Cases with one or more 1st, 2nd or 3rd degree relatives affected by UC/CD were defined as familial case.
Results: In UC and CD, familial cases compared with sporadic cases had an earlier disease onset (UC: 33 years [IQR 25-44] vs 37 years [IQR 27-49]; p < 0.0001); (CD: 27 years [IQR 21-351 vs 29 years [IQR 22-40]; p < 0.0001), higher prevalence of extraintestinal immune-related manifestations (EIMs) (UC: 17.2% vs 14%; p = 0.04); (CD: 30.1% vs 23.6%; p < 0.0001). Familial CD had higher percentage of ileocolic location (42.7% vs 51.8%; p = 0.0001), penetrating behavior (21% vs 17.6%; p = 0.01) and perianal disease (32% vs 27.1%; p = 0.003). Differences are not influenced by degree of consanguinity.
Conclusion: When a sufficiently powered cohort is evaluated, familial aggregation in IBD is associated to an earlier disease onset, more EIMs and more severe phenotype in CD. This feature should be taken into account at establishing predictors of disease course. (C) 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
Filiaciones:
Andreu, M:
Pompeu Fabra Univ, Hosp Mar, IMIM Inst Hosp Mar Invest Med, Dept Gastroenterol, Barcelona, Catalonia, Spain
Marquez, L:
Pompeu Fabra Univ, Hosp Mar, IMIM Inst Hosp Mar Invest Med, Dept Gastroenterol, Barcelona, Catalonia, Spain
Domenech, E:
Hosp Germans Trias, Dept Gastroenterol, Badalona, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Gisbert, JP:
Hosp La Princesa, Gastroenterol Unit, Madrid, Spain
Inst Invest Sanitaria Princesa, Gastroenterol Unit, Madrid, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Garcia, V:
Hosp Reina Sofia, Dept Gastroenterol, Cordoba, Spain
Marin-Jimenez, I:
Hosp Gen Univ Gregorio Maranon, Dept Gastroenterol, Madrid, Spain
Penalva, M:
Bellvitge Univ Hosp, Dept Gastroenterol, Barcelona, Spain
Gomollon, F:
Univ Hosp Clin, Dept Gastroenterol, Zaragoza, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Calvet, X:
Univ Hosp Parc Tauli, Dept Gastroenterol, Sabadell, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Merino, O:
Hosp Cruces, Dept Gastroenterol, Baracaldo, Spain
Garcia-Planella, E:
Hosp Santa Creu & Sant Pau, Dept Gastroenterol, Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Vazquez-Romero, N:
Hosp Gen Univ Elche, Dept Gastroenterol, Alicante, Spain
Esteve, M:
Hosp Mutua Terrassa, Dept Gastroenterol, Barcelona, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Nos, P:
Hosp Univ La Fe, Dept Gastroenterol, Valencia, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Gutierrez, A:
Gen Hosp, Dept Gastroenterol, Alicante, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Vera, I:
Hosp Univ Puerta de Hierro, Dept Gastroenterol, Madrid, Spain
Cabriada, JL:
Hosp Galdakao, Deparment Gastroenterol, Viscaya, Spain
Martin, MD:
Hosp La Paz, Dept Gastroenterol, Madrid, Spain
Canas-Ventura, A:
Pompeu Fabra Univ, Hosp Mar, IMIM Inst Hosp Mar Invest Med, Dept Gastroenterol, Barcelona, Catalonia, Spain
Panes, J:
Univ Barcelona, Dept Gastroenterol, Hosp Clin, IDIBAPS, Barcelona, Catalonia, Spain
Ctr Invest Biomed Red Enfermedades Hepat & Digest, Barcelona, Spain
Bronze, Green Published
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