View of statins as antimicrobials in cardiovascular risk modification
Por:
Kozarov, E, Padro, T, Badimon, L
Publicada:
1 jun 2014
Resumen:
Atherosclerosis is a complex arterial pathological development underlying heart attack and stroke and a leading cause of death in developed and now also in developing countries. The primary processes that lead to the inflammatory lipid-laden proliferative lesion, obstructing the blood flow, and referred to as atherosclerotic plaque are dyslipidaemia and inflammation. Here, we will review one of the most efficient classes of drugs indicated for management of cardiovascular disease (CVD), statins. We will assess their pleiotropic effects that emerged from CVD applications, focusing this review specifically on plausible antimicrobial activity. Only recently gaining strength, the recognition of possible antibacterial activity may extend the statin applicability for vascular as well as to other critical inflammatory conditions.
Filiaciones:
Kozarov, E:
Biomed Res Inst St Pau IIB St Pau, Cardiovasc Res Ctr CSIC ICCC, Barcelona 08025, Spain
Columbia Univ, Med Ctr, New York, NY 10032 USA
Padro, T:
Biomed Res Inst St Pau IIB St Pau, Cardiovasc Res Ctr CSIC ICCC, Barcelona 08025, Spain
Badimon, L:
Biomed Res Inst St Pau IIB St Pau, Cardiovasc Res Ctr CSIC ICCC, Barcelona 08025, Spain
UAB, Cardiovasc Res Chair, Barcelona, Spain
Bronze
|