Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Por:
Escott-Price, V, Bellenguez, C, Wang, LS, Choi, SH, Harold, D, Jones, L, Holmans, P, Gerrish, A, Vedernikov, A, Richards, A, DeStefano, AL, Lambert, JC, Ibrahim-Verbaas, CA, Naj, AC, Sims, R, Jun, G, Bis, JC, Beecham, GW, Grenier-Boley, B, Russo, G, Thornton-Wells, TA, Denning, N, Smith, AV, Chouraki, V, Thomas, C, Ikram, MA, Zelenika, D, Vardarajan, BN, Kamatani, Y, Lin, CF, Schmidt, H, Kunkle, B, Dunstan, ML, Vronskaya, M, Johnson, AD, Ruiz, A, Bihoreau, MT, Reitz, C, Pasquier, F, Hollingworth, P, Hanon, O, Fitzpatrick, AL, Buxbaum, JD, Campion, D, Crane, PK, Baldwin, C, Becker, T, Gudnason, V, Cruchaga, C, Craig, D, Amin, N, Berr, C, Lopez, OL, De Jager, PL, Deramecourt, V, Johnston, JA, Evans, D, Lovestone, S, Letenneur, L, Hernandez, I, Rubinsztein, DC, Eiriksdottir, G, Sleegers, K, Goate, AM, Fievet, N, Huentelman, MJ, Gill, M, Brown, K, Kamboh, MI, Keller, L, Barberger-Gateau, P, McGuinness, B, Larson, EB, Myers, AJ, Dufouil, C, Todd, S, Wallon, D, Love, S, Rogaeva, E, Gallacher, J, St George-Hyslop, P, Clarimon, J, Lleo, A, Bayer, A, Tsuang, DW, Yu, L, Tsolaki, M, Bossu, P, Spalletta, G, Proitsi, P, Collinge, J, Sorbi, S, Garcia, FS, Fox, NC, Hardy, J, Naranjo, MCD, Bosco, P, Clarke, R, Brayne, C, Galimberti, D, Scarpini, E, Bonuccelli, U, Mancuso, M, Siciliano, G, Moebus, S, Mecocci, P, Del Zompo, M, Maier, W, Hampel, H, Pilotto, A, Frank-Garcia, A, Panza, F, Solfrizzi, V, Caffarra, P, Nacmias, B, Perry, W, Mayhaus, M, Lannfelt, L, Hakonarson, H, Pichler, S, Carrasquillo, MM, Ingelsson, M, Beekly, D, Alvarez, V, Zou, FG, Valladares, O, Younkin, SG, Coto, E, Hamilton-Nelson, KL, Gu, W, Razquin, C, Pastor, P, Mateo, I, Owen, MJ, Faber, KM, Jonsson, PV, Combarros, O, O'Donovan, MC, Cantwell, LB, Soininen, H, Blacker, D, Mead, S, Mosley, TH, Bennett, DA, Harris, TB, Fratiglioni, L, Holmes, C, de Bruijn, RFAG, Passmore, P, Montine, TJ, Bettens, K, Rotter, JI, Brice, A, Morgan, K, Foroud, TM, Kukull, WA, Hannequin, D, Powell, JF, Nalls, MA, Ritchie, K, Lunetta, KL, Kauwe, JSK, Boerwinkle, E, Riemenschneider, M, Boada, M, Hiltunen, M, Martin, ER, Schmidt, R, Rujescu, D, Dartigues, JF, Mayeux, R, Tzourio, C, Hofman, A, Nothen, MM, Graff, C, Psaty, BM, Haines, JL, Lathrop, M, Pericak-Vance, MA, Launer, LJ, Van Broeckhoven, C, Farrer, LA, van Duijn, CM, Ramirez, A, Seshadri, S, Schellenberg, GD, Amouyel, P, Williams, J
Publicada:
12 jun 2014
Resumen:
Background: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls.
Principal Findings: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4x10(-6)) and 14 (IGHV1-67 p = 7.9x10(-8)) which indexed novel susceptibility loci.
Significance: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
Filiaciones:
Escott-Price, V:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Bellenguez, C:
INSERM, U744, F-59045 Lille, France
Univ Lille 2, Lille, France
Inst Pasteur, F-59019 Lille, France
Wang, LS:
Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Choi, SH:
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Harold, D:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Jones, L:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Holmans, P:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Gerrish, A:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Vedernikov, A:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Richards, A:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
DeStefano, AL:
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Lambert, JC:
INSERM, U744, F-59045 Lille, France
Univ Lille 2, Lille, France
Inst Pasteur, F-59019 Lille, France
Ibrahim-Verbaas, CA:
Erasmus MC Univ Med Ctr, Dept Epidemiol & Neurol, Rotterdam, Netherlands
Naj, AC:
Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Sims, R:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Jun, G:
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA
Bis, JC:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Beecham, GW:
Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA
Univ Miami, Dr John T Macdonald Fdn, Dept Human Genet, Miami, FL USA
Grenier-Boley, B:
INSERM, U744, F-59045 Lille, France
Univ Lille 2, Lille, France
Inst Pasteur, F-59019 Lille, France
Russo, G:
ETH Univ Zurich, Funct Genom Ctr Zurich, Zurich, Switzerland
Thornton-Wells, TA:
Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA
Denning, N:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Smith, AV:
Univ Iceland, Fac Med, Reykjavik, Iceland
Iceland Heart Assoc, Kopavogur, Iceland
Chouraki, V:
INSERM, U744, F-59045 Lille, France
Univ Lille 2, Lille, France
Inst Pasteur, F-59019 Lille, France
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Thomas, C:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Ikram, MA:
Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands
Erasmus MC Univ Med Ctr, Dept Radiol, Rotterdam, Netherlands
Netherlands Consortium Hlth Aging, Leiden, Netherlands
Zelenika, D:
CEA, Inst Genom, Ctr Natl Genotypage, Evry, France
UCL Inst Neurol, Dept Mol Neurosci, Reta Lila Weston Res Labs, London, England
Vardarajan, BN:
Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA
Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY USA
Columbia Univ, Dept Neurol, Gertrude H Sergievsky Ctr, New York, NY USA
Kamatani, Y:
Fdn Jean Dausset CEPH, Paris, France
Lin, CF:
Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Schmidt, H:
Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria
Kunkle, B:
Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA
Dunstan, ML:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Vronskaya, M:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Johnson, AD:
NHLBI, Cardiovasc Epidemiol & Human Genom Branch, Framingham Heart Study, Framingham, MA USA
Ruiz, A:
Fundacio ACE, Memory Clin, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Bihoreau, MT:
CEA, Inst Genom, Ctr Natl Genotypage, Evry, France
Reitz, C:
Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY USA
Columbia Univ, Dept Neurol, Gertrude H Sergievsky Ctr, New York, NY USA
Pasquier, F:
Univ Lille 2, Lille, France
CHRU Lille, CNR MAJ, F-59037 Lille, France
Hollingworth, P:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Hanon, O:
Univ Paris 05, Sorbonne Paris 5, Broca Hosp, Dept Geriatr, Paris, France
Fitzpatrick, AL:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA
Buxbaum, JD:
Mt Sinai Sch Med, Dept Neurosci, New York, NY USA
Mt Sinai Sch Med, Dept Psychiat, New York, NY USA
Mt Sinai Sch Med, Dept Genet, New York, NY USA
Mt Sinai Sch Med, Dept Genom Sci, New York, NY USA
Campion, D:
Rouen Univ Hosp, CNR MAJ, INSERM, U1079, F-76031 Rouen, France
Crane, PK:
Univ Washington, Dept Med, Seattle, WA USA
Baldwin, C:
Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA
Becker, T:
Univ Bonn, German Ctr Neurodegenerat Dis DZNE, Bonn, Germany
Univ Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany
Gudnason, V:
Univ Iceland, Fac Med, Reykjavik, Iceland
Iceland Heart Assoc, Kopavogur, Iceland
Cruchaga, C:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Washington Univ, Sch Med, Hope Ctr Program Prot Aggregat & Neurodegenerat, St Louis, MO USA
Craig, D:
Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Ageing Grp, Belfast, Antrim, North Ireland
Amin, N:
Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
Berr, C:
Hop Colombiere, Fac Med, INSERM, U1061, Montpellier, France
Lopez, OL:
Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA
De Jager, PL:
Brigham & Womens Hosp, Dept Neurol & Psychiat, Inst Neurosci, Program Translat NeuroPsychiat Genom, Boston, MA 02115 USA
Harvard Univ, Sch Med, Boston, MA USA
Broad Inst, Program Med & Populat Genet, Boston, MA USA
Deramecourt, V:
Univ Lille 2, Lille, France
CHRU Lille, CNR MAJ, F-59037 Lille, France
Johnston, JA:
Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Ageing Grp, Belfast, Antrim, North Ireland
Evans, D:
Rush Univ, Med Ctr, Dept Internal Med, Rush Inst Hlth Aging, Chicago, IL 60612 USA
Lovestone, S:
Kings Coll London, Inst Psychiat, Dept Neurosci, London WC2R 2LS, England
Letenneur, L:
Victor Segalen Univ, INSERM, U897, F-33076 Bordeaux, France
Hernandez, I:
Fundacio ACE, Memory Clin, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Rubinsztein, DC:
Univ Cambridge, Cambridge Inst Med Res, Cambridge, England
Eiriksdottir, G:
Iceland Heart Assoc, Kopavogur, Iceland
Sleegers, K:
Univ Antwerp VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2020 Antwerp, Belgium
Goate, AM:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Washington Univ, Sch Med, Hope Ctr Program Prot Aggregat & Neurodegenerat, St Louis, MO USA
Fievet, N:
INSERM, U744, F-59045 Lille, France
Inst Pasteur, F-59019 Lille, France
Huentelman, MJ:
Translat Genom Res Inst, Neurogen Div, Phoenix, AZ USA
Gill, M:
Univ Dublin Trinity Coll, Discipline Psychiat, Dublin 2, Ireland
Brown, K:
Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2RD, England
Kamboh, MI:
Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA
Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA USA
Keller, L:
Karolinska Inst, Dept Neurobiol, Care Sci & Soc, Aging Reasearch Ctr, Stockholm, Sweden
Stockholm Univ, S-10691 Stockholm, Sweden
Barberger-Gateau, P:
Kings Coll London, Inst Psychiat, Dept Neurosci, London WC2R 2LS, England
McGuinness, B:
Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Ageing Grp, Belfast, Antrim, North Ireland
Larson, EB:
Univ Washington, Dept Med, Seattle, WA USA
Grp Hlth Res Inst, Grp Hlth, Seattle, WA USA
Myers, AJ:
Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA
Dufouil, C:
Victor Segalen Univ, INSERM, U897, F-33076 Bordeaux, France
Todd, S:
Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Ageing Grp, Belfast, Antrim, North Ireland
Wallon, D:
Rouen Univ Hosp, CNR MAJ, INSERM, U1079, F-76031 Rouen, France
Love, S:
Univ Bristol, Inst Clin Neurosci, Sch Clin Sci, Frenchay Hosp, Bristol, Avon, England
Rogaeva, E:
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Gallacher, J:
Cardiff Univ, Neuadd Meirionnydd, Univ Wales Hosp, Inst Primary Care & Publ Hlth, Cardiff CF10 3AX, S Glam, Wales
St George-Hyslop, P:
Univ Cambridge, Cambridge Inst Med Res, Cambridge, England
Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada
Univ Cambridge, Dept Clin Neurosci, Cambridge, England
Clarimon, J:
Univ Autonoma Barcelona, St Pau Hosp, IIB St Pau, Dept Neurol, E-08193 Barcelona, Spain
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Barcelona, Spain
Lleo, A:
Univ Autonoma Barcelona, St Pau Hosp, IIB St Pau, Dept Neurol, E-08193 Barcelona, Spain
Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Barcelona, Spain
Bayer, A:
Cardiff Univ, Neuadd Meirionnydd, Univ Wales Hosp, Inst Primary Care & Publ Hlth, Cardiff CF10 3AX, S Glam, Wales
Tsuang, DW:
Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
Yu, L:
Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
Tsolaki, M:
Aristotle Univ Thessaloniki, Dept Neurol 3, GR-54006 Thessaloniki, Greece
Bossu, P:
Fdn Santa Lucia, Rome, Italy
Spalletta, G:
Fdn Santa Lucia, Rome, Italy
Proitsi, P:
Kings Coll London, Inst Psychiat, Dept Neurosci, London WC2R 2LS, England
Collinge, J:
UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London, England
Sorbi, S:
Univ Florence, NEUROFARBA Dept Neurosci Psychol Drug Res & Child, Florence, Italy
Univ Florence, Ctr Ric Trasferimento & Alta Formaz DENOTHE, Florence, Italy
Garcia, FS:
Hosp Univ Dr Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain
Fox, NC:
UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Hardy, J:
Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England
Inst Neurol, Reta Lilla Weston Labs, London WC1N 3BG, England
Naranjo, MCD:
Hosp Univ Dr Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain
Bosco, P:
IRCCS Assoc Oasi Maria SS, Troina, Italy
Clarke, R:
Univ Oxford, Clin Trial Serv Unit, OHAP, Oxford, England
Brayne, C:
Univ Cambridge, Inst Publ Hlth, CFAS, Cambridge, England
Galimberti, D:
Univ Milan, Fdn Ca Granda, IRCCS Osped Policlin, Milan, Italy
Scarpini, E:
Univ Milan, Fdn Ca Granda, IRCCS Osped Policlin, Milan, Italy
Bonuccelli, U:
Univ Pisa, Neurol Clin, Pisa, Italy
Mancuso, M:
Univ Pisa, Neurol Clin, Pisa, Italy
Siciliano, G:
Univ Pisa, Neurol Clin, Pisa, Italy
Moebus, S:
Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany
Mecocci, P:
Univ Perugia, Dept Clin & Expt Med, Sect Gerontol & Geriatr, I-06100 Perugia, Italy
Del Zompo, M:
Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy
Maier, W:
Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany
Hampel, H:
Goethe Univ Frankfurt, Dept Psychiat, D-60054 Frankfurt, Germany
Univ Munich, Dept Psychiat, D-80539 Munich, Germany
Pilotto, A:
IRCCS Casa Sollievo Sofferenza, Gerontol & Geriatr Res Lab, San Giovanni Rotondo, Italy
Frank-Garcia, A:
Ctr Biol Mol Severo Ochoa CSIC UAM, Madrid, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Hosp la Paz IdIPaz, Inst Invest Sanitaria, Madrid, Spain
Panza, F:
Univ Bari, Ctr Aging Brain, Dept Geriatr, Bari, Italy
Solfrizzi, V:
Univ Bari, Ctr Aging Brain, Dept Geriatr, Bari, Italy
Caffarra, P:
Univ Parma, Dept Neurosci, I-43100 Parma, Italy
Ctr Cognit Disorders AUSL, Parma, Italy
Nacmias, B:
Univ Florence, NEUROFARBA Dept Neurosci Psychol Drug Res & Child, Florence, Italy
Univ Florence, Ctr Ric Trasferimento & Alta Formaz DENOTHE, Florence, Italy
Perry, W:
Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA
Univ Miami, Dr John T Macdonald Fdn, Dept Human Genet, Miami, FL USA
Mayhaus, M:
Univ Hosp, Dept Psychiat, Saarland, Germany
Lannfelt, L:
Uppsala Univ, Dept Publ Health Geriatr, Uppsala, Sweden
Hakonarson, H:
Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
Pichler, S:
Univ Hosp, Dept Psychiat, Saarland, Germany
Carrasquillo, MM:
Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Ingelsson, M:
Uppsala Univ, Dept Publ Health Geriatr, Uppsala, Sweden
Beekly, D:
Univ Washington, Natl Alzheimers Coordinating Ctr, Seattle, WA 98195 USA
Alvarez, V:
Genet Mol Huca Oviedo, Oviedo, Spain
Zou, FG:
Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Valladares, O:
Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Younkin, SG:
Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Coto, E:
Genet Mol Huca Oviedo, Oviedo, Spain
Hamilton-Nelson, KL:
Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA
Gu, W:
Univ Hosp, Dept Psychiat, Saarland, Germany
Razquin, C:
Univ Navarra, Sch Med, Ctr Appl Med Res, Neurogenet Lab,Div Neurosci, E-31080 Pamplona, Spain
Pastor, P:
Univ Navarra, Sch Med, Ctr Appl Med Res, Neurogenet Lab,Div Neurosci, E-31080 Pamplona, Spain
Inst Salud Carlos III, Ctr Invest Biome Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Mateo, I:
Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, E-39005 Santander, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, CIBERNED, E-39005 Santander, Spain
IFIMAV, Santander, Spain
Owen, MJ:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Faber, KM:
Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46204 USA
Jonsson, PV:
Univ Iceland, Fac Med, Reykjavik, Iceland
Landspitali Univ Hosp, Reykjavik, Iceland
Combarros, O:
Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, E-39005 Santander, Spain
Univ Cantabria, Marques de Valdecilla Univ Hosp, CIBERNED, E-39005 Santander, Spain
IFIMAV, Santander, Spain
O'Donovan, MC:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Cantwell, LB:
Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Soininen, H:
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland
Blacker, D:
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA
Mead, S:
UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London, England
Mosley, TH:
Univ Mississippi, Med Ctr, Dept Geriatr Med, Jackson, MS 39216 USA
Bennett, DA:
Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA
Harris, TB:
NIH, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
Fratiglioni, L:
Stockholm Univ, S-10691 Stockholm, Sweden
Karolinska Inst, Care Sci & Soc, Dept Neurobiol, Aging Res Ctr, Stockholm, Sweden
Karolinska Univ Hosp Huddinge, Genet Unit, Dept Geriatr Med, Stockholm, Sweden
Holmes, C:
Univ Southampton, Sch Med, Div Clin Neurosci, Southampton, Hants, England
de Bruijn, RFAG:
Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands
Passmore, P:
Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Publ Hlth, Ageing Grp, Belfast, Antrim, North Ireland
Montine, TJ:
Univ Washington, Dept Pathol, Seattle, WA 98195 USA
Bettens, K:
Univ Antwerp VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2020 Antwerp, Belgium
Rotter, JI:
Harbor UCLA Med Ctr, Los Angeles BioMed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA
Brice, A:
Univ Paris 06, INSERM UMR S975 CNRS UMR 7225, Ctr Rech, Inst Cerveau & Moelle Epiniere CRICM,Hop Salpetri, Paris, France
Hop La Pitie Salpetriere, AP HP, Paris, France
Morgan, K:
Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2RD, England
Foroud, TM:
Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46204 USA
Kukull, WA:
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
Hannequin, D:
Rouen Univ Hosp, CNR MAJ, INSERM, U1079, F-76031 Rouen, France
Powell, JF:
Kings Coll London, Inst Psychiat, Dept Neurosci, London WC2R 2LS, England
Nalls, MA:
NIA, Neurogenet Lab, Intramural Res Program, Bethesda, MD 20892 USA
Ritchie, K:
Hop Colombiere, Fac Med, INSERM, U1061, Montpellier, France
Univ London Imperial Coll Sci Technol & Med, London, England
Lunetta, KL:
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Kauwe, JSK:
Brigham Young Univ, Dept Biol, Provo, UT 84602 USA
Boerwinkle, E:
Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA
Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Houston, TX 77030 USA
Riemenschneider, M:
Univ Hosp, Dept Psychiat, Saarland, Germany
Boada, M:
Fundacio ACE, Memory Clin, Inst Catala Neurociencies Aplicades, Barcelona, Spain
Univ Autonoma Barcelona VHIR UAB, Inst Recerca, Hosp Univ Vall d Hebron, Barcelona, Spain
Hiltunen, M:
Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland
Kuopio Univ Hosp, Dept Neurol, SF-70210 Kuopio, Finland
Schmidt, R:
Med Univ Graz, Dept Neurol, Graz, Austria
Rujescu, D:
Univ Munich, Dept Psychiat, D-80539 Munich, Germany
Dartigues, JF:
Victor Segalen Univ, INSERM, U897, F-33076 Bordeaux, France
CHU Bordeaux, Ctr Memoire Ressources & Rech Bordeaux, Bordeaux, France
Mayeux, R:
Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY USA
Columbia Univ, Dept Neurol, Gertrude H Sergievsky Ctr, New York, NY USA
Tzourio, C:
Victor Segalen Univ, INSERM, U708, Bordeaux, France
Hofman, A:
Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
Erasmus MC Univ Med Ctr, Dept Neurol, Rotterdam, Netherlands
Erasmus MC Univ Med Ctr, Dept Radiol, Rotterdam, Netherlands
Netherlands Consortium Hlth Aging, Leiden, Netherlands
Nothen, MM:
German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany
Univ Bonn, Life & Brain Ctr, Dept Genom, Inst Human Genet, Bonn, Germany
Graff, C:
Karolinska Univ Hosp Huddinge, Genet Unit, Dept Geriatr Med, Stockholm, Sweden
Karolinska Inst, Dept Neurobiol, Care Sci & Soc, KIADRC, Stockholm, Sweden
Psaty, BM:
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA
Grp Hlth Cooperat Puget Sound, Grp Hlth Res Inst, Seattle, WA USA
Haines, JL:
Vanderbilt Univ, Vanderbilt Ctr Human Genet Res, Nashville, TN 37235 USA
Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA
Lathrop, M:
Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA
Fdn Jean Dausset CEPH, Paris, France
McGill Univ, Montreal, PQ, Canada
Genome Quebec Innovat Ctr, Montreal, PQ, Canada
Pericak-Vance, MA:
Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA
Univ Miami, Dr John T Macdonald Fdn, Dept Human Genet, Miami, FL USA
Launer, LJ:
NIH, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
Van Broeckhoven, C:
Univ Antwerp VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2610 Antwerp, Belgium
Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2020 Antwerp, Belgium
Farrer, LA:
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA
Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Ophthalmol, Boston, MA 02118 USA
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA
van Duijn, CM:
Erasmus MC Univ Med Ctr, Dept Epidemiol, Rotterdam, Netherlands
Netherlands Consortium Hlth Aging, Leiden, Netherlands
Ctr Med Syst Biol, Leiden, Netherlands
Ramirez, A:
Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany
Univ Bonn, Inst Human Genet, Bonn, Germany
Seshadri, S:
Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA
Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Schellenberg, GD:
Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
Amouyel, P:
INSERM, U744, F-59045 Lille, France
Univ Lille 2, Lille, France
Inst Pasteur, F-59019 Lille, France
CHRU Lille, CNR MAJ, F-59037 Lille, France
CHRU Lille, F-59037 Lille, France
Williams, J:
Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF10 3AX, S Glam, Wales
Gold, Green Published, Green Accepted
|