Focal therapy for prostate cancer. Alternative treatment
Por:
Gomez-Veiga, F, Martinez-Breijo, S, Solsona-Narbon, E, Hernandez, C, Ciudin, A, Ribal, MJ, Dickinson, L, Moore, C, Ahmed, H, Antolin, AR, Breda, A, Gaya, J, Portela-Pereira, P, Emberton, M
Publicada:
1 sep 2014
Resumen:
Context: The great controversy surrounding the treatment of localized prostate cancer is related with its possibilities of radical treatment or active surveillance. The objective of this paper is to analyze the rationale selection among current focal therapy modalities regarding tumor and patient selection.
Evidence acquisition: Current articles about advantages and disadvantages on the treatment of localized prostate cancer as well as information about focal therapy regarding tumour selection, characteristics and indications cited in MEDLINE search were reviewed. Summary of evidence: Focal therapy standardized criteria must be: low risk tumors, PSA < 10-15, Gleason score <= 6, and unilateral presentation all supported by image-guided biopsy and nuclear magnetic resonance (NMR). There are doubts about the suitability of focal therapy in cases of bilateralism or in those with Gleason score 3 + 4 or PSA > 15.
Conclusions: Focal therapy is an alternative for localized prostate cancer treatment. However, some aspects of their diagnosis and selection criteria should be defined by prospective studies which should provide knowledge about the indication for focal therapy. (C) 2013 AEU. Published by Elsevier Espana, S.L. All rights reserved.
Filiaciones:
Gomez-Veiga, F:
Hosp Univ Salamanca, Serv Urol, La Coruna, Spain
Complejo Hosp Univ A Coruna, La Coruna, Spain
Martinez-Breijo, S:
Hosp Univ Salamanca, Serv Urol, La Coruna, Spain
Complejo Hosp Univ A Coruna, La Coruna, Spain
Solsona-Narbon, E:
Inst Valenciano Oncol, Serv Urol, Valencia, Spain
Hernandez, C:
Hosp Gregorio Maranon, Serv Urol, Madrid, Spain
Ciudin, A:
Hosp Gregorio Maranon, Serv Urol, Madrid, Spain
Ribal, MJ:
Hosp Clin Barcelona, Serv Urol, Barcelona, Spain
Dickinson, L:
Univ Coll London Hosp, Dept Urol, London, England
Moore, C:
Univ Coll London Hosp, Dept Urol, London, England
Ahmed, H:
Univ Coll London Hosp, Dept Urol, London, England
Antolin, AR:
Hosp Univ 12 Octubre, Serv Urol, Madrid, Spain
Breda, A:
Fdn Puigvert, Serv Urol, Barcelona, Spain
Gaya, J:
Fdn Puigvert, Serv Urol, Barcelona, Spain
Portela-Pereira, P:
Hosp Univ Salamanca, Serv Urol, La Coruna, Spain
Complejo Hosp Univ A Coruna, La Coruna, Spain
Emberton, M:
Univ Coll London Hosp, Dept Urol, London, England
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