Pharmacogenetic study of second-generation antipsychotic long-term treatment metabolic side effects (the SLiM Study): Rationale, objectives, design and sample description
Por:
Pina-Camacho, L, Diaz-Caneja, CM, Saiz, PA, Bobes, J, Corripio, I, Grasa, E, Rodriguez-Jimenez, R, Fernandez, M, Sanjuan, J, Garcia-Lopez, A, Tapia-Casellas, C, Alvarez-Blazquez, M, Fraguas, D, Mitjans, M, Arias, B, Arango, C
Publicada:
1 oct 2014
Resumen:
Aim: Weight gain is an important and common side effect of second generation antipsychotics (SGAs). Furthermore, these drugs can induce other side effects associated with higher cardiovascular morbidity and mortality, such as insulin resistance, diabetes or metabolic syndrome. Preliminary studies show that inter-individual genetic differences produce varying degrees of vulnerability to the different SGA-induced side effects. The Second-generation antipsychotic Long-term treatment Metabolic side effects (SLiM) study aims to identify clinical, environmental and genetic factors that explain inter-individual differences in weight gain and metabolic changes in drug-naive patients after six months of treatment with SGAs.
Materials and methods: The SLIM study is a multicenter, observational, six-month pharmacogenetic study where a cohort of 307 drug-naive paediatric and adult patients (age range 8.8-90.1 years) and a cohort of 150 age- and sex- matched healthy controls (7.8-73.2 years) were recruited.
Results: This paper describes the rationale, objectives and design of the study and provides a description of the sample at baseline.
Conclusions: Results from the SUM study will provide a better understanding of the clinical, environmental, and genetic factors involved in weight gain and metabolic disturbances associated with SGA treatment. (C) 2014 SEP y SEPB. Published by Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
Pina-Camacho, L:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Fac Med,IiSGM, Serv Psiquiatria Nino & Adolescente,Dept Psiquiat, E-28040 Madrid, Spain
Kings Coll London, Inst Psychiat, Dept Child & Adolescent Psychiat, London, England
Diaz-Caneja, CM:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Fac Med,IiSGM, Serv Psiquiatria Nino & Adolescente,Dept Psiquiat, E-28040 Madrid, Spain
Saiz, PA:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Oviedo, Area Psiquiatria, Oviedo, Spain
Inst Univ Neurociencias Principado Asturias INEUR, Oviedo, Spain
Bobes, J:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Oviedo, Area Psiquiatria, Oviedo, Spain
Inst Univ Neurociencias Principado Asturias INEUR, Oviedo, Spain
Corripio, I:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, IIB St Pau, Serv Psiquiatria, E-08193 Barcelona, Spain
Grasa, E:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, IIB St Pau, Serv Psiquiatria, E-08193 Barcelona, Spain
Rodriguez-Jimenez, R:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Inst Invest Hosp Octubre 12 I 12, Serv Psiquiatria, E-28040 Madrid, Spain
Fernandez, M:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Basque Country, Hosp Univ Santiago Apostol, Serv Psiquiatria, Vitoria, Spain
Sanjuan, J:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Valencia, Hosp Clin INCLIVA, Dept Psiquiatria, Valencia, Spain
Garcia-Lopez, A:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Hosp Univ Ramon & Cajal, Serv Psiquiatria, Madrid, Spain
Tapia-Casellas, C:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Fac Med,IiSGM, Serv Psiquiatria Nino & Adolescente,Dept Psiquiat, E-28040 Madrid, Spain
Alvarez-Blazquez, M:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Fac Med,IiSGM, Serv Psiquiatria Nino & Adolescente,Dept Psiquiat, E-28040 Madrid, Spain
Fraguas, D:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Fac Med,IiSGM, Serv Psiquiatria Nino & Adolescente,Dept Psiquiat, E-28040 Madrid, Spain
Mitjans, M:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Fac Biol, Dept Biol Anim, Unitat Antropol, Barcelona, Spain
Univ Barcelona, Inst Biomed IBUB, Barcelona, Spain
Arias, B:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Barcelona, Fac Biol, Dept Biol Anim, Unitat Antropol, Barcelona, Spain
Univ Barcelona, Inst Biomed IBUB, Barcelona, Spain
Arango, C:
CIBER Area Salud Mental CIBERSAM, Madrid, Spain
Univ Complutense, Hosp Gen Univ Gregorio Maranon, Fac Med,IiSGM, Serv Psiquiatria Nino & Adolescente,Dept Psiquiat, E-28040 Madrid, Spain
Open Access
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