The impact of donor insemination on the risk of preeclampsia: a systematic review and meta-analysis
Por:
Gonzalez-Comadran, M, Avila, JU, Tascon, AS, Jimenez, R, Sola, I, Brassesco, M, Carreras, R, Checa, MA
Publicada:
1 nov 2014
Resumen:
A systematic review and meta-analysis were performed to evaluate whether women who conceive with donor sperm have an increased risk of preeclampsia compared with those who use their partner's sperm. Studies that compared women who were impregnated by donor and partner sperm were included. The main outcomes assessed were preeclampsia and gestational hypertension rates. Altogether, 10,898 women (2342 pregnancies by donor sperm versus 8556 by the partner's sperm) were included from seven observational studies. Conception using donor sperm was associated with an increased risk of preeclampsia (odds ratio [OR] 1.63, 95% CI 1.36-1.95) compared with using a partner's sperm. No difference was observed in the risk of gestational hypertension (OR 0.94, 95% CI 0.43-2.03). In conclusion, pregnancies achieved by donor sperm significantly increase the risk of preeclampsia, although the underlying mechanisms remain unclear. Additional studies are required to confirm these findings. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Filiaciones:
Gonzalez-Comadran, M:
Hosp del Mar, Dept Obstet & Gynaecol, Barcelona, Spain
Avila, JU:
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Tascon, AS:
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Jimenez, R:
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Sola, I:
IIB St Pau, Inst Biomed Res, Barcelona, Spain
CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain
Brassesco, M:
Ctr Infertilidad & Reprod Humana CIRH, Barcelona, Spain
Carreras, R:
Hosp del Mar, Dept Obstet & Gynaecol, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Checa, MA:
Hosp del Mar, Dept Obstet & Gynaecol, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Ctr Infertilidad & Reprod Humana CIRH, Barcelona, Spain
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