Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure
Por:
Jalan, R, Saliba, F, Pavesi, M, Amoros, A, Moreau, R, Gines, P, Levesque, E, Durand, F, Angeli, P, Caraceni, P, Hopf, C, Alessandria, C, Rodriguez, E, Solis-Munoz, P, Laleman, W, Trebicka, J, Zeuzem, S, Gustot, T, Mookerjee, R, Elkrief, L, Soriano, G, Cordoba, J, Morando, F, Gerbes, A, Agarwal, B, Samuel, D, Bernardi, M, Arroyo, V
Publicada:
1 nov 2014
Resumen:
Background & Aims: Acute-on-chronic liver failure (ACLF) is a frequent syndrome (30% prevalence), characterized by acute decompensation of cirrhosis, organ failure(s) and high short-term mortality. This study develops and validates a specific prognostic score for ACLF patients.
Methods: Data from 1349 patients included in the CANONIC study were used. First, a simplified organ function scoring system (CLIF Consortium Organ Failure score, CLIF-C OFs) was developed to diagnose ACLF using data from all patients. Subsequently, in 275 patients with ACLF, CLIP-C OFs and two other independent predictors of mortality (age and white blood cell count) were combined to develop a specific prognostic score for ACLF (CLIF Consortium ACLF score [CLIF-C ACLFs]). A concordance index (C-index) was used to compare the discrimination abilities of CLIF-C ACLF, MELD, MELD-sodium (MELD-Na), and Child-Pugh (CPs) scores. The CLIF-C ACLFs was validated in an external cohort and assessed for sequential use.
Results: The CLIF-C ACLFs showed a significantly higher predictive accuracy than MELDs, MELD-Nas, and CPs, reducing (19-28%) the corresponding prediction error rates at all main time points after ACLF diagnosis (28, 90, 180, and 365 days) in both the CANONIC and the external validation cohort. CLIF-C ACLFs computed at 48 h, 3-7 days, and 8-15 days after ACLF diagnosis predicted the 28-day mortality significantly better than at diagnosis.
Conclusions: The CLIF-C ACLFs at ACLF diagnosis is superior to the MELDs and MELD-Nas in predicting mortality. The CLIP-C ACLFs is a clinically relevant, validated scoring system that can be used sequentially to stratify the risk of mortality in ACLF patients. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
Filiaciones:
Jalan, R:
Royal Free Hosp, UCL Med Sch, UCL Inst Liver & Digest Hlth, Liver Failure Grp, London NW3 2QG, England
Saliba, F:
Hop Paul Brousse, Villejuif, France
Unite INSERM U785, Paris, France
Pavesi, M:
EASL CLIF Consortium, Data Management Ctr, Barcelona, Spain
Amoros, A:
EASL CLIF Consortium, Data Management Ctr, Barcelona, Spain
Moreau, R:
Hop Beaujon, INSERM U773, Clichy, France
Hop Beaujon, Serv Hepatol, Clichy, France
Gines, P:
Hosp Clin Barcelona, Barcelona, Spain
Levesque, E:
Hop Paul Brousse, Villejuif, France
Unite INSERM U785, Paris, France
Durand, F:
Hop Beaujon, INSERM U773, Clichy, France
Hop Beaujon, Serv Hepatol, Clichy, France
Angeli, P:
Univ Padua, I-35100 Padua, Italy
Caraceni, P:
Policlin St Orsola Malpighi, Bologna, Italy
Hopf, C:
Univ Munich, Klinikum Univ Munchen, Munich, Germany
Alessandria, C:
Univ Turin, I-10124 Turin, Italy
Rodriguez, E:
Hosp Clin Barcelona, Barcelona, Spain
Solis-Munoz, P:
Kings Coll London, London WC2R 2LS, England
Laleman, W:
Univ Hosp Gasthuisberg, Leuven, Belgium
Trebicka, J:
Univ Hosp Bonn, Bonn, Germany
Zeuzem, S:
JW Goethe Univ Hosp, Frankfurt, Germany
Gustot, T:
Erasme Hosp Brussels, Brussels, Belgium
Elkrief, L:
Hop Beaujon, INSERM U773, Clichy, France
Hop Beaujon, Serv Hepatol, Clichy, France
Soriano, G:
Hosp Santa Cruz & St Pablo, Barcelona, Spain
Cordoba, J:
Hosp Valle De Hebron, Barcelona, Spain
Morando, F:
Policlin St Orsola Malpighi, Bologna, Italy
Gerbes, A:
Univ Munich, Klinikum Univ Munchen, Munich, Germany
Agarwal, B:
Royal Free Hosp, UCL Med Sch, UCL Inst Liver & Digest Hlth, Liver Failure Grp, London NW3 2QG, England
Samuel, D:
Hop Paul Brousse, Villejuif, France
Unite INSERM U785, Paris, France
Bernardi, M:
Policlin St Orsola Malpighi, Bologna, Italy
Green Published
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