Low blood levels of sTWEAK are related to locoregional failure in head and neck cancer
Por:
Aviles-Jurado, FX, Terra, X, Gomez, D, Flores, JC, Raventos, A, Maymo-Masip, E, Leon, X, Serrano-Gonzalvo, V, Vendrell, J, Figuerola, E, Chacon, MR
Publicada:
1 jul 2015
Resumen:
Identifying serum pre-treatment molecular markers that can predict response to therapy is of great interest in head and neck oncology and is required to develop personalized treatments that maximize survival while minimizing morbidity. The main aim was to investigate the potential prognostic significance of tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and its receptors, fibroblast growth factor-inducible 14 (Fn14) and CD163, in head and neck squamous cell carcinoma (HNSCC). The study comprised 37 consecutive patients with pathologically confirmed, untreated HNSCC. Serum and tissue samples from these patients were available for study. We determined sTWEAK and sCD163 levels in serum from 37 HNSCC patients by ELISA. TWEAK, CD163, Fn14 and TNF-alpha gene expression were detected by real-time RT-PCR in 111 matched tissue samples (tumoral, adjacent and distal/normal mucosa). Our results showed a significant relationship between low sTWEAK levels and poor locoregional control of the disease. Kaplan-Meier curves indicated that the locoregional recurrence-free survival rate in patients with low sTWEAK circulating levels was significantly lower than in patients with high levels, and that high CD136/TWEAK expression ratio in tumors was also related to poor prognosis. sTWEAK pre-treatment serum levels might be used as prognostic non-invasive biomarkers for locoregional control in patients with HNSCC. Future investigations are warranted to determine the potential prognostic significance of this non-invasive biomarker in the rapid discrimination according to the locoregional control achieved in patients who received a non-surgical organ preservation treatment.
Filiaciones:
Aviles-Jurado, FX:
Univ Rovira & Virgili, Hosp Univ Tarragona Joan 23, IISPV, Otorhinolaryngol Head Neck Surg Dept, E-43007 Tarragona, Catalonia, Spain
Univ Rovira & Virgili, Otolaryngol Dis Res Grp HJ23, Inst Invest Sanitaria Pere Virgili, E-43007 Tarragona, Catalonia, Spain
Terra, X:
Univ Rovira & Virgili, Otolaryngol Dis Res Grp HJ23, Inst Invest Sanitaria Pere Virgili, E-43007 Tarragona, Catalonia, Spain
Univ Rovira & Virgili, MoBioFood Res Grp, Dept Bioquim & Biotecnol, E-43007 Tarragona, Catalonia, Spain
Gomez, D:
Hosp St Joan Reus, Dept Radiat Oncol, Tarragona, Catalonia, Spain
Flores, JC:
Univ Rovira & Virgili, Hosp Univ Tarragona Joan 23, IISPV, Otorhinolaryngol Head Neck Surg Dept, E-43007 Tarragona, Catalonia, Spain
Raventos, A:
Univ Rovira & Virgili, Dept Pathol, Hosp Univ Tarragona Joan 23, E-43007 Tarragona, Catalonia, Spain
Maymo-Masip, E:
Univ Rovira & Virgili, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Hosp Univ Joan Tarragona 23, Inst Invest Sanitaria Pere Virgili, E-43007 Tarragona, Catalonia, Spain
Leon, X:
Univ Autonoma Barcelona, Otorhinolaryngol Head Neck Surg Dept, Hosp Santa Creu & St Pau, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, Networking Res Ctr Bioengn Biomat & Nanomed CIBER, MICINN, ISCIII, E-08193 Barcelona, Spain
Serrano-Gonzalvo, V:
Univ Rovira & Virgili, Hosp Univ Tarragona Joan 23, IISPV, Anetesiol & Reanimat Dept, E-43007 Tarragona, Catalonia, Spain
Vendrell, J:
Univ Rovira & Virgili, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Hosp Univ Joan Tarragona 23, Inst Invest Sanitaria Pere Virgili, E-43007 Tarragona, Catalonia, Spain
Figuerola, E:
Univ Rovira & Virgili, Hosp Univ Tarragona Joan 23, IISPV, Otorhinolaryngol Head Neck Surg Dept, E-43007 Tarragona, Catalonia, Spain
Univ Rovira & Virgili, Otolaryngol Dis Res Grp HJ23, Inst Invest Sanitaria Pere Virgili, E-43007 Tarragona, Catalonia, Spain
Chacon, MR:
Univ Rovira & Virgili, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Hosp Univ Joan Tarragona 23, Inst Invest Sanitaria Pere Virgili, E-43007 Tarragona, Catalonia, Spain
Hosp Univ Tarragona Joan XXIII, Res Unit, Tarragona 43007, Catalonia, Spain
|