Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease
Por:
Spataro, N, Calafell, F, Cervera-Carles, L, Casals, F, Pagonabarraga, J, Pascual-Sedano, B, Campolongo, A, Kulisevsky, J, Lleo, A, Navarro, A, Clarimon, J, Bosch, E
Publicada:
1 abr 2015
Resumen:
Parkinson's disease (PD) can be divided into familial (Mendelian) and sporadic forms. A number of causal genes have been discovered for the Mendelian form, which constitutes 10-20% of the total cases. Genome-wide association studies have successfully uncovered a number of susceptibility loci for sporadic cases but those only explain a small fraction (6-7%) of PD heritability. It has been observed that some genes that confer susceptibility to PD through common risk variants also contain rare causing mutations for the Mendelian forms of the disease. These results suggest a possible functional link between Mendelian and sporadic PD and led us to investigate the role that rare and low-frequency variants could have on the sporadic form. Through a targeting approach, we have resequenced at 49x coverage the exons and regulatory regions of 38 genes (including Mendelian and susceptibility PD genes) in 249 sporadic PD patients and 145 unrelated controls of European origin. Unlike susceptibility genes, Mendelian genes show a clear general enrichment of rare functional variants in PD cases, observed directly as well as with Tajima's D statistic and several collapsing methods. Our findings suggest that rare variation on PD Mendelian genes may have a role in the sporadic forms of the disease.
Filiaciones:
Spataro, N:
Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Expt & Hlth Sci, Barcelona 08003, Spain
Calafell, F:
Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Expt & Hlth Sci, Barcelona 08003, Spain
Cervera-Carles, L:
Univ Autonoma Barcelona, Dept Neurol, Inst Invest Biomed St Pau Hosp St Pau, Barcelona 08025, Spain
Ctr Networking Biomed Res Neurodegenerat Dis CIBE, Madrid, Spain
Casals, F:
Univ Pompeu Fabra, Genom Core Facil, Barcelona Biomed Res Pk PRBB, Barcelona 08003, Spain
Pagonabarraga, J:
Univ Autonoma Barcelona, Dept Neurol, Inst Invest Biomed St Pau Hosp St Pau, Barcelona 08025, Spain
Ctr Networking Biomed Res Neurodegenerat Dis CIBE, Madrid, Spain
Pascual-Sedano, B:
Univ Autonoma Barcelona, Dept Neurol, Inst Invest Biomed St Pau Hosp St Pau, Barcelona 08025, Spain
Ctr Networking Biomed Res Neurodegenerat Dis CIBE, Madrid, Spain
Campolongo, A:
Univ Autonoma Barcelona, Dept Neurol, Inst Invest Biomed St Pau Hosp St Pau, Barcelona 08025, Spain
Ctr Networking Biomed Res Neurodegenerat Dis CIBE, Madrid, Spain
Kulisevsky, J:
Univ Autonoma Barcelona, Dept Neurol, Inst Invest Biomed St Pau Hosp St Pau, Barcelona 08025, Spain
Ctr Networking Biomed Res Neurodegenerat Dis CIBE, Madrid, Spain
Univ Oberta Catalunya, Dept Hlth Sci, Catalonia, Spain
Lleo, A:
Univ Autonoma Barcelona, Dept Neurol, Inst Invest Biomed St Pau Hosp St Pau, Barcelona 08025, Spain
Ctr Networking Biomed Res Neurodegenerat Dis CIBE, Madrid, Spain
Navarro, A:
Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Expt & Hlth Sci, Barcelona 08003, Spain
Barcelona Biomed Res Pk PRBB, Natl Inst Bioinformat INB, Barcelona 08003, Spain
Barcelona Biomed Res Pk PRBB, ICREA, Barcelona 08003, Spain
Barcelona Biomed Res Pk PRBB, Ctr Genom Regulat CRG, Barcelona 08003, Spain
Clarimon, J:
Univ Autonoma Barcelona, Dept Neurol, Inst Invest Biomed St Pau Hosp St Pau, Barcelona 08025, Spain
Ctr Networking Biomed Res Neurodegenerat Dis CIBE, Madrid, Spain
Bosch, E:
Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Expt & Hlth Sci, Barcelona 08003, Spain
Green Accepted, Green Published, Hybrid Gold
|