Premorbid adjustment and clinical correlates of cognitive impairment in first-episode psychosis. The PEPsCog Study
Por:
Cuesta, MJ, Sanchez-Torres, AM, Cabrera, B, Bioque, M, Merchan-Naranjo, J, Corripio, I, Gonzalez-Pinto, A, Lobo, A, Bombin, I, de la Serna, E, Sanjuan, J, Parellada, M, Saiz-Ruiz, J, Bernardo, M
Publicada:
1 may 2015
Resumen:
Background: The extent to which socio-demographic, clinical, and premorbid adjustment variables contribute to cognitive deficits in first-episode schizophrenia spectrum disorders remains to be ascertained. Aims: To examine the pattern and magnitude of cognitive impairment in first-episode psychosis patients, the profile of impairment across psychosis subtypes and the associations with premorbid adjustment.
Methods: 226 first-episode psychosis patients and 225 healthy controls were assessed in the PEPsCog study, as part of the PEPs study.
Results: Patients showed slight to moderate cognitive impairment, verbal memory being the domain most impaired compared to controls. Broad affective spectrum patients had better premorbid IQ and outperformed the schizophrenia and other psychosis groups in executive function, and had better global cognitive function than the schizophrenia group. Adolescent premorbid adjustment together with age, gender, parental socio-economic status, and mean daily antipsychotic doses were the factors that best explained patients' cognitive performance. General and adolescent premorbid adjustment, age and parental socio-economic status were the best predictors of cognitive performance in controls.
Conclusions: Poorer premorbid adjustment together with socio-demographic factors and higher daily antipsychotic doses were related to a generalized cognitive impairment and to a lower premorbid intellectual reserve, suggesting that neurodevelopmental impairment was present before illness onset. (C) 2015 Elsevier B.V. All rights reserved.
Filiaciones:
Cuesta, MJ:
Complejo Hosp Navarra, Dept Psychiat, Pamplona 31008, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Sanchez-Torres, AM:
Complejo Hosp Navarra, Dept Psychiat, Pamplona 31008, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Cabrera, B:
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
CIBERSAM, Oviedo, Spain
Bioque, M:
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
CIBERSAM, Oviedo, Spain
Merchan-Naranjo, J:
CIBERSAM, Oviedo, Spain
Univ Complutense, Child & Adolescent Psychiat Dept, Hosp Gen Univ Gregorio Maranon, Sch Med,IiSGM,CIBERSAM, E-28040 Madrid, Spain
Corripio, I:
CIBERSAM, Oviedo, Spain
Hosp Santa Creu & Sant Pau, IIB ST PAU, Dept Psychiat, Barcelona, Spain
Univ Autonoma Barcelona, E-08193 Barcelona, Spain
Gonzalez-Pinto, A:
CIBERSAM, Oviedo, Spain
Univ Basque Country, Hosp Univ Alava, Dept Psychiat, Vitoria, Spain
Lobo, A:
CIBERSAM, Oviedo, Spain
Univ Zaragoza, IIS Aragon, E-50009 Zaragoza, Spain
Bombin, I:
CIBERSAM, Oviedo, Spain
Reintegra Fdn, Oviedo, Spain
de la Serna, E:
CIBERSAM, Oviedo, Spain
Hosp Clin Barcelona, Dept Child & Adolescent Psychiat & Psychol, Inst Clin Neurociencies, Barcelona, Spain
Sanjuan, J:
CIBERSAM, Oviedo, Spain
Clin Hosp INCLIVA, Valencia, Spain
Parellada, M:
CIBERSAM, Oviedo, Spain
Univ Complutense, Child & Adolescent Psychiat Dept, Hosp Gen Univ Gregorio Maranon, Sch Med,IiSGM,CIBERSAM, E-28040 Madrid, Spain
Saiz-Ruiz, J:
CIBERSAM, Oviedo, Spain
Univ Alcala de Henares, Hosp Ramon y Cajal, IRyCIS, Dept Psychiat, Madrid, Spain
Bernardo, M:
Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain
Univ Barcelona, Dept Psychiat & Clin Psychobiol, IDIBAPS, Barcelona, Spain
CIBERSAM, Oviedo, Spain
Bellvitge Univ Hosp IDIBELL, Dept Psychiat, Barcelona, Spain.
Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain.
Univ Oviedo, Dept Psychiat, Oviedo, Spain.
Univ Basque Country UPV EHU, Deparment Neurosci, Biscay, Spain.
BioCruces Hlth Res Inst, Biscay, Spain.
Univ Complutense, Hosp Univ Octubre 12, E-28040 Madrid, Spain.
St Boi Llobregat, Parc Sanitari St Joan Deu, Barcelona, Spain.
FIDMAG Hermanas Hosp Res Fdn, Barcelona, Spain.
La Fe Univ, Teaching Unit Psychiat, Valencia, Spain.
Univ Valencia, Polytech Hosp, CIBERSAM, ISNPR, Valencia, Spain.
INAD, Serv Psiquiatria, Barcelona, Spain.
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