Telling true from false: cannabis users show increased susceptibility to false memories
Por:
Riba, J, Valle, M, Sampedro, F, Rodriguez-Pujadas, A, Martinez-Horta, S, Kulisevsky, J, Rodriguez-Fornells, A
Publicada:
1 jun 2015
Resumen:
Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a crucial aspect of reality monitoring that relies on adequate memory function and cognitive control. Using functional magnetic resonance imaging, we show that abstinent cannabis users have an increased susceptibility to false memories, failing to identify lure stimuli as events that never occurred. In addition to impaired performance, cannabis users display reduced activation in areas associated with memory processing within the lateral and medial temporal lobe (MTL), and in parietal and frontal brain regions involved in attention and performance monitoring. Furthermore, cannabis consumption was inversely correlated with MTL activity, suggesting that the drug is especially detrimental to the episodic aspects of memory. These findings indicate that cannabis users have an increased susceptibility to memory distortions even when abstinent and drug-free, suggesting a long-lasting compromise of memory and cognitive control mechanisms involved in reality monitoring.
Filiaciones:
Riba, J:
IIB St Pau, St Pau Inst Biomed Res, Human Neuropsychopharmacol Grp, Barcelona 08025, Spain
Hosp Santa Creu & Sant Pau, Serv Farmacol Clin, Ctr Invest Medicaments, Barcelona, Spain
Univ Autonoma Barcelona, CIBERSAM, Ctr Invest Biomed Red Salud Mental, Dept Farmacol & Terapeut, E-08193 Barcelona, Spain
Valle, M:
Hosp Santa Creu & Sant Pau, Serv Farmacol Clin, Ctr Invest Medicaments, Barcelona, Spain
Univ Autonoma Barcelona, CIBERSAM, Ctr Invest Biomed Red Salud Mental, Dept Farmacol & Terapeut, E-08193 Barcelona, Spain
IIB St Pau, Pharmacokinet & Pharmacodynam Modelling & Simulat, Barcelona 08025, Spain
Sampedro, F:
Univ Autonoma Barcelona, Sch Med, E-08193 Barcelona, Spain
Rodriguez-Pujadas, A:
IIB St Pau, St Pau Inst Biomed Res, Human Neuropsychopharmacol Grp, Barcelona 08025, Spain
Martinez-Horta, S:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
Kulisevsky, J:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Dept Neurol, Movement Disorders Unit, E-08193 Barcelona, Spain
Ctr Invest Biomed Red Enfermedades Neurodegenerat, Barcelona, Spain
Rodriguez-Fornells, A:
Bellvitge Biomed Res Inst IDIBELL, Cognit & Brain Plast Grp, Barcelona, Spain
Univ Barcelona, Dept Basic Psychol, Barcelona, Spain
ICREA, Catalan Inst Res & Adv Studies, Barcelona, Spain
Green Published, Hybrid Gold
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