Convergent genetic and expression data implicate immunity in Alzheimer's disease

Por: Jones, L, Lambert, JC, Wang, LS, Choi, SH, Harold, D, Vedernikov, A, Escott-Price, V, Stone, T, Richards, A, Bellenguez, C, Ibrahim-Verbaas, CA, Naj, AC, Sims, R, Gerrish, A, Jun, G, DeStefano, AL, Bis, JC, Beecham, GW, Grenier-Boley, B, Russo, G, Thornton-Wells, TA, Jones, N, Smith, AV, Chouraki, V, Thomas, C, Ikram, MA, Zelenika, D, Vardarajan, BN, Kamatani, Y, Lin, CF, Schmidt, H, Kunkle, BW, Dunstan, ML, Ruiz, A, Bihoreau, MT, Reitz, C, Pasquier, F, Hollingworth, P, Hanon, O, Fitzpatrick, AL, Buxbaum, JD, Campion, D, Crane, PK, Becker, T, Gudnason, V, Cruchaga, C, Craig, D, Amin, N, Berr, C, Lopez, OL, De Jager, PL, Deramecourt, V, Johnston, JA, Evans, D, Lovestone, S, Letteneur, L, Kornhuber, J, Tarraga, L, Rubinsztein, DC, Eiriksdottir, G, Sleegers, K, Goate, AM, Fievet, N, Huentelman, MJ, Gill, M, Emilsson, V, Brown, K, Kamboh, MI, Keller, L, Barberger-Gateau, P, McGuinness, B, Larson, EB, Myers, AJ, Dufouil, C, Todd, S, Wallon, D, Love, S, Kehoe, P, Rogaeva, E, Gallacher, J, St George-Hyslop, P, Clarimon, J, Lleo, A, Bayer, A, Tsuang, DW, Yu, L, Tsolaki, M, Bossu, P, Spalletta, G, Proitsi, P, Collinge, J, Sorbi, S, Garcia, FS, Fox, N, Hardy, J, Naranjo, MCD, Razquin, C, Bosco, P, Clarke, R, Brayne, C, Galimberti, D, Mancuso, M, Moebus, S, Mecocci, P, del Zompo, M, Maier, W, Hampel, H, Pilotto, A, Bullido, M, Panza, F, Caffarra, P, Nacmias, B, Gilbert, JR, Mayhaus, M, Jessen, F, Dichgans, M, Lannfelt, L, Hakon, H, Pichler, S, Carrasquillo, MM, Ingelsson, M, Beekly, D, Alavarez, V, Zou, FG, Valladares, O, Younkin, SG, Coto, E, Hamilton-Nelson, KL, Mateo, I, Owen, MJ, Faber, KM, Jonsson, PV, Combarros, O, O'Donovan, MC, Cantwell, LB, Soininen, H, Blacker, D, Mead, S, Mosley, TH, Bennett, DA, Harris, TB, Fratiglioni, L, Holmes, C, de Bruijn, RFAG, Passmore, P, Montine, TJ, Bettens, K, Rotter, JI, Brice, A, Morgan, K, Foroud, TM, Kukull, WA, Hannequin, D, Powell, JF, Nails, MA, Ritchie, K, Lunetta, KL, Kauwe, JSK, Boerwinkle, E, Riemenschneider, M, Boada, M, Hiltunen, M, Martin, ER, Pastor, P, Schmidt, R, Rujescu, D, Dartigues, JF, Mayeux, R, Tzourio, C, Hofman, A, Nothen, MM, Graff, C, Psaty, BM, Haines, JL, Lathrop, M, Pericak-Vance, MA, Launer, LJ, Farrer, LA, van Duijn, CM, Van Broeckhoven, C, Ramirez, A, Schellenberg, GD, Seshadri, S, Amouyel, P, Williams, J, Holmans, PA

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Publicada: 1 jun 2015

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Filiaciones:
Jones, L:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Lambert, JC:
 Inserm U744, F-59000 Lille, France

 Univ Lille 2, F-59000 Lille, France

 Inst Pasteur, F-59000 Lille, France

Wang, LS:
 Univ Penn Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Choi, SH:
 Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

Harold, D:
 St James Hosp, Neuropsychiat Genet Grp, Dept Psychiat, Trinity Ctr Hlth Sci, Dublin 8, Ireland

Vedernikov, A:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Escott-Price, V:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Stone, T:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Richards, A:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Bellenguez, C:
 Inserm U744, F-59000 Lille, France

 Univ Lille 2, F-59000 Lille, France

 Inst Pasteur, F-59000 Lille, France

Ibrahim-Verbaas, CA:
 Erasmus MC Univ Med Ctr, Dept Epidemiol Clin Genet & Neurol, NL-3015 CE Rotterdam, Netherlands

Naj, AC:
 Univ Miami, John P Hussman Inst Human Genom, Coral Gables, FL 33124 USA

Sims, R:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Gerrish, A:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Jun, G:
 Boston Univ Sch Med, Dept Med Biomed Genet, Boston, MA 02218 USA

 Boston Univ Sch Med, Dept Ophthalmol, Boston, MA 02215 USA

 Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

DeStefano, AL:
 Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

Bis, JC:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

Beecham, GW:
 Univ Miami, John P Hussman Inst Human Genom, Coral Gables, FL 33124 USA

 Univ Miami, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL 33124 USA

Grenier-Boley, B:
 Inserm U744, F-59000 Lille, France

 Univ Lille 2, F-59000 Lille, France

 Inst Pasteur, F-59000 Lille, France

Russo, G:
 Funct Genom Ctr, CH-8038 Zurich, Switzerland

Thornton-Wells, TA:
 Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA

Jones, N:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Smith, AV:
 Univ Iceland, Fac Pharmaceut Sci, IS-5254000 Reykjavik, Iceland

 Iceland Heart Assoc, IS-5254000 Kopavogur, Iceland

Chouraki, V:
 Inserm U744, F-59000 Lille, France

 Univ Lille 2, F-59000 Lille, France

 Inst Pasteur, F-59000 Lille, France

Thomas, C:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Ikram, MA:
 Erasmus MC Univ Med Ctr, Dept Epidemiol, NL-3015 CE Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Neurol, NL-3015 CE Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Radiol, NL-3015 CE Rotterdam, Netherlands

 Netherlands Consortium Hlth Aging, Leiden, Netherlands

Zelenika, D:
 CEA, Inst Genom, Ctr Natl Genotypage, F-91300 Evry, France

Vardarajan, BN:
 Boston Univ Sch Med, Dept Med Biomed Genet, Boston, MA 02218 USA

Kamatani, Y:
 Fdn Jean Dausset CEPH, F-75010 Paris, France

Lin, CF:
 Univ Penn Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Schmidt, H:
 Med Univ Graz, Inst Mol Biol & Biochem, A-8010 Graz, Austria

Kunkle, BW:
 Univ Miami, John P Hussman Inst Human Genom, Coral Gables, FL 33124 USA

Dunstan, ML:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Ruiz, A:
 Fundacio ACE, Memory Clin, Inst Catala Neurociencies Aplicades, Barcelona 8029, Spain

Bihoreau, MT:
 CEA, Inst Genom, Ctr Natl Genotypage, F-91300 Evry, France

Reitz, C:
 Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY 10027 USA

 Columbia Univ, Dept Neurol, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

Pasquier, F:
 Univ Lille 2, F-59000 Lille, France

 CHRU Lille, F-59037 Lille, France

Hollingworth, P:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Hanon, O:
 Univ Paris 05, Fac Med, UMR Inserm 894, F-75014 Paris, France

Fitzpatrick, AL:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

 Univ Washington, Dept Epidemiol, Seattle, WA 98101 USA

 Univ Washington, Dept Global Hlth, Seattle, WA 98101 USA

Buxbaum, JD:
 Mt Sinai Sch Med, Dept Neurosci, New York, NY 10027 USA

 Mt Sinai Sch Med, Dept Psychiat, New York, NY 10027 USA

 Mt Sinai Sch Med, Dept Genet, New York, NY 10027 USA

 Mt Sinai Sch Med, Dept Genom Sci, New York, NY 10027 USA

Campion, D:
 Ctr Hosp Rouvray, Fac Med, INSERM U614, F-76000 Rouen, France

Crane, PK:
 Univ Washington, Dept Med, Seattle, WA 98195 USA

Becker, T:
 Univ Bonn, German Ctr Neurodegenerat Dis DZNE, D-53113 Bonn, Germany

 Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-53113 Bonn, Germany

Gudnason, V:
 Univ Iceland, Fac Pharmaceut Sci, IS-5254000 Reykjavik, Iceland

 Iceland Heart Assoc, IS-5254000 Kopavogur, Iceland

Cruchaga, C:
 Washington Univ Sch Med, Dept Psychiat, St Louis, MO USA

 Washington Univ Sch Med, Hope Ctr Program Prot Aggregat & Neurodegenerat, St Louis, MO USA

Craig, D:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast BT7 1NN, Antrim, North Ireland

Amin, N:
 Erasmus MC Univ Med Ctr, Dept Epidemiol, NL-3015 CE Rotterdam, Netherlands

Berr, C:
 Hop La Colombiere, INSERM U888, F-34000 Montpellier, France

Lopez, OL:
 Univ Pittsburgh Sch Med, Dept Neurol, Pittsburgh, PA 15213 USA

De Jager, PL:
 Brigham & Womens Hosp, Program Translat NeuroPsychiat Genom, Inst Neurosci, Dept Neurol & Psychiat, Boston, MA 02215 USA

 Harvard Univ, Sch Med, Boston, MA 02215 USA

 Broad Inst, Program Med & Populat Genet, Boston, MA 02215 USA

Deramecourt, V:
 Inserm U744, F-59000 Lille, France

 CHRU Lille, F-59037 Lille, France

Johnston, JA:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast BT7 1NN, Antrim, North Ireland

Evans, D:
 Rush Univ Med Ctr, Dept Internal Med, Rush Inst Hlth Aging, Chicago, IL 60612 USA

Lovestone, S:
 Kings Coll London, Inst Psychiat, Dept Neurosci, London SE5, England

Letteneur, L:
 Victor Segalen Univ, Inserm U897, F-33076 Bordeaux, France

Kornhuber, J:
 Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany

Tarraga, L:
 Fundacio ACE, Memory Clin, Inst Catala Neurociencies Aplicades, Barcelona 8029, Spain

Rubinsztein, DC:
 Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 OXY, England

Eiriksdottir, G:
 Iceland Heart Assoc, IS-5254000 Kopavogur, Iceland

Sleegers, K:
 VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2000 Antwerp, Belgium

 Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2000 Antwerp, Belgium

Goate, AM:
 Washington Univ Sch Med, Dept Psychiat, St Louis, MO USA

 Washington Univ Sch Med, Hope Ctr Program Prot Aggregat & Neurodegenerat, St Louis, MO USA

Fievet, N:
 Inserm U744, F-59000 Lille, France

 Inst Pasteur, F-59000 Lille, France

Huentelman, MJ:
 Translat Genom Res Inst, Neurogen Div, Phoenix, AZ 85004 USA

Gill, M:
 St James Hosp, Mercers Inst Res Aging, Dublin 8, Ireland

 Univ Ireland Trinity Coll, Dublin 8, Ireland

Emilsson, V:
 Univ Iceland, Fac Pharmaceut Sci, IS-5254000 Reykjavik, Iceland

 Iceland Heart Assoc, IS-5254000 Kopavogur, Iceland

Brown, K:
 Univ Nottingham, Inst Genet, Queens Med Ctr, Nottingham NG7 2UH, England

Kamboh, MI:
 Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15213 USA

 Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA 15213 USA

Keller, L:
 Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Reasearch Ctr, S-17177 Stockholm, Sweden

 Stockholm Univ, S-17177 Stockholm, Sweden

Barberger-Gateau, P:
 Victor Segalen Univ, Inserm U897, F-33076 Bordeaux, France

McGuinness, B:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast BT7 1NN, Antrim, North Ireland

Larson, EB:
 Univ Washington, Dept Med, Seattle, WA 98195 USA

 Grp Hlth, Grp Hlth Res Inst, Seattle, WA 98195 USA

Myers, AJ:
 Univ Miami, Dept Psychiat & Behav Sci, Miller Sch Med, Miami, FL 33124 USA

Dufouil, C:
 Victor Segalen Univ, Inserm U897, F-33076 Bordeaux, France

Todd, S:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast BT7 1NN, Antrim, North Ireland

Wallon, D:
 Ctr Hosp Rouvray, Fac Med, INSERM U614, F-76000 Rouen, France

Love, S:
 Univ Bristol, Clin Neurosci, Bristol BS10 5NB, Avon, England

Kehoe, P:
 Univ Bristol, Clin Neurosci, Bristol BS10 5NB, Avon, England

Rogaeva, E:
 Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON M5S 1A1, Canada

Gallacher, J:
 Cardiff Univ, Inst Primary Care & Publ Hlth, Univ Wales Hosp, Cardiff CF14 4XN, S Glam, Wales

St George-Hyslop, P:
 Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON M5S 1A1, Canada

 Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 1TN, England

 Univ Cambridge, Dept Clin Neurosci, Cambridge CB2 1TN, England

Clarimon, J:
 Univ Autonoma Barcelona, Neurol Dept, IIB St Pau, St Pau Hosp, Barcelona 08026, Spain

 Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Barcelona, Spain

Lleo, A:
 Univ Autonoma Barcelona, Neurol Dept, IIB St Pau, St Pau Hosp, Barcelona 08026, Spain

 Ctr Networker Biomed Res Neurodegenerat Dis CIBER, Barcelona, Spain

Bayer, A:
 Cardiff Univ, Inst Primary Care & Publ Hlth, Univ Wales Hosp, Cardiff CF14 4XN, S Glam, Wales

Tsuang, DW:
 Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

Yu, L:
 Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

Tsolaki, M:
 Aristotle Univ Thessaloniki, Thessaloniki 54621, Greece

Bossu, P:
 Fdn Santa Lucia, Clin & Behav Neurol, I-00142 Rome, Italy

Spalletta, G:
 Fdn Santa Lucia, Clin & Behav Neurol, I-00142 Rome, Italy

Proitsi, P:
 Kings Coll London, Inst Psychiat, Dept Neurosci, London SE5, England

Collinge, J:
 UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London WC1N 3BG, England

Sorbi, S:
 Univ Florence, Ctr Ric Trasferimento & Alta Formaz DENOTHE, Florence, Italy

Garcia, FS:
 Hosp Univ Dr Negrin, Dept Immunol, Las Palmas Gran Canaria 35012, Spain

Fox, N:
 UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London WC1N 3BG, England

Hardy, J:
 Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England

 Inst Neurol, Reta Lilla Weston Labs, London WC1N 3BG, England

Naranjo, MCD:
 Hosp Univ Dr Negrin, Dept Immunol, Las Palmas Gran Canaria 35012, Spain

Razquin, C:
 Univ Navarra Sch Med, Div Neurosci, Ctr Appl Med Res, Neurogenet Lab, Pamplona 28023, Spain

Bosco, P:
 IRCCS Assoc Oasi Maria SS, I-94018 Troina, Italy

Clarke, R:
 Univ Oxford, Clin Trial Serv Unit, OHAP, Oxford OX1 2JD, England

Brayne, C:
 Univ Cambridge, Inst Publ Hlth, CFAS, Cambridge CB2 1TN, England

Galimberti, D:
 Univ Milan, Fdn Ca Granda, IRCCS Osped Policlin, I-20122 Milan, Italy

Mancuso, M:
 Univ Pisa, Neurol Clin, I-56126 Pisa, Italy

Moebus, S:
 Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol, Urban Epidemiol, Univ Hosp Essen, D-45141 Essen, Germany

Mecocci, P:
 Univ Perugia, Sect Gerontol & Geriatr, Dept Clin & Expt Med, I-06100 Perugia, Italy

del Zompo, M:
 Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, I-09123 Cagliari, Italy

Maier, W:
 Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany

 German Ctr Neurodegenerat Dis DZNE, D-53113 Bonn, Germany

Hampel, H:
 Univ Paris 06, Dept Neurol, Inst Memoire & Malad Alzheimer, Paris, France

Pilotto, A:
 IRCCS Casa Sollievo Sofferenza, Gerontol & Geriatr Res Lab, I-71013 San Giovanni Rotondo, FG, Italy

Bullido, M:
 Ctr Biol Mol Severo Ochoa CSIC UAM, Madrid 28046, Spain

 Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

 Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain

Panza, F:
 Univ Bari, Ctr Aging Brain, Dept Geriatr, I-70121 Bari, Italy

Caffarra, P:
 Univ Parma, Dept Neurosci, I-43100 Parma, Italy

 Ctr Cognit Disorders AUSL, Parma, Italy

Nacmias, B:
 Univ Florence, Dept Neurol & Psychiat Sci, I-50121 Florence, Italy

 Univ Florence, Ctr Ric Trasferimento & Alta Formaz DENOTHE, Florence, Italy

Gilbert, JR:
 Univ Miami, John P Hussman Inst Human Genom, Coral Gables, FL 33124 USA

 Univ Miami, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL 33124 USA

Mayhaus, M:
 Univ Hosp, Dept Psychiat, D-66424 Saarland, Germany

Jessen, F:
 Univ Bonn, Dept Psychiat & Psychotherapy, Bonn, Germany

 German Ctr Neurodegenerat Dis DZNE, D-53113 Bonn, Germany

Dichgans, M:
 Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

 German Ctr Neurodegenerat Dis DZNE, D-80336 Munich, Germany

Lannfelt, L:
 Uppsala Univ, Dept Publ Hlth Geriatr, S-75312 Uppsala, Sweden

Hakon, H:
 Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

Carrasquillo, MM:
 Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

Ingelsson, M:
 Uppsala Univ, Dept Publ Hlth Geriatr, S-75312 Uppsala, Sweden

Beekly, D:
 Univ Washington, Natl Alzheimers Coordinating Ctr, Seattle, WA 98195 USA

Alavarez, V:
 Genet Mol Huca Oviedo, Oviedo 33006, Spain

Zou, FG:
 Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

Valladares, O:
 Univ Penn Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Younkin, SG:
 Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

Coto, E:
 Genet Mol Huca Oviedo, Oviedo 33006, Spain

Hamilton-Nelson, KL:
 Univ Miami, John P Hussman Inst Human Genom, Coral Gables, FL 33124 USA

Mateo, I:
 Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, E-39005 Santander, Spain

 Univ Cantabria, Marques de Valdecilla Univ Hosp, CIBERNED, E-39005 Santander, Spain

 IFIMAV, Santander 39005, Spain

Owen, MJ:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Faber, KM:
 Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

Jonsson, PV:
 Landspitali Univ Hosp, IS-5431000 Reykjavik, Iceland

Combarros, O:
 Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, E-39005 Santander, Spain

 Univ Cantabria, Marques de Valdecilla Univ Hosp, CIBERNED, E-39005 Santander, Spain

 IFIMAV, Santander 39005, Spain

O'Donovan, MC:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Cantwell, LB:
 Univ Penn Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Soininen, H:
 Univ Eastern Finland, Inst Clin Med Neurol, Kuopio 70211, Finland

 Kuopio Univ Hosp, Dept Neurol, FIN-70211 Kuopio, Finland

Blacker, D:
 Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

 Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Gen Hosp, Boston, MA 02115 USA

Mead, S:
 UCL Inst Neurol, Dept Neurodegenerat Dis, MRC Prion Unit, London WC1N 3BG, England

Mosley, TH:
 Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

Bennett, DA:
 Rush Univ Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

 Rush Univ Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

Harris, TB:
 NIH, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA

Fratiglioni, L:
 Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Reasearch Ctr, S-11418 Stockholm, Sweden

 Stockholm Univ, S-11418 Stockholm, Sweden

 Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Genet Unit, S-14186 Stockholm, Sweden

Holmes, C:
 Univ Southampton, Sch Med, Div Clin Neurosci, Southampton SO17 1BJ, Hants, England

de Bruijn, RFAG:
 Erasmus MC Univ Med Ctr, Dept Epidemiol, NL-3015 CE Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Neurol, NL-3015 CE Rotterdam, Netherlands

Passmore, P:
 Queens Univ Belfast, Ageing Grp, Ctr Publ Hlth, Sch Med Dent & Biomed Sci, Belfast BT7 1NN, Antrim, North Ireland

Montine, TJ:
 Univ Washington, Dept Pathol, Seattle, WA 98195 USA

Bettens, K:
 VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2000 Antwerp, Belgium

 Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2000 Antwerp, Belgium

Rotter, JI:
 Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA

Brice, A:
 CRicm UMRS975, Paris, France

 Hop La Pitie Salpetriere, AP HP, F-75013 Paris, France

Morgan, K:
 Univ Nottingham, Inst Genet, Queens Med Ctr, Nottingham NG7 2UH, England

Foroud, TM:
 Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN 46202 USA

Kukull, WA:
 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

Hannequin, D:
 Ctr Hosp Rouvray, Fac Med, INSERM U614, F-76000 Rouen, France

Powell, JF:
 Kings Coll London, Inst Psychiat, Dept Neurosci, London SE5, England

Nails, MA:
 NIA, Neurogenet Lab, Intramural Res Program, Bethesda, MD 20892 USA

Ritchie, K:
 Hop La Colombiere, INSERM U888, F-34000 Montpellier, France

Lunetta, KL:
 Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

Kauwe, JSK:
 Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 OXY, England

Boerwinkle, E:
 Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

 Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA

 Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Houston, TX 77030 USA

Riemenschneider, M:
 Univ Hosp, Dept Psychiat, Saarland 66424, Germany

Boada, M:
 Fundacio ACE, Memory Clin, Inst Catala Neurociencies Aplicades, Barcelona 8029, Spain

Hiltunen, M:
 Univ Eastern Finland, Inst Clin Med Neurol, Kuopio 70211, Finland

 Kuopio Univ Hosp, Dept Neurol, FIN-70211 Kuopio, Finland

Martin, ER:
 Univ Miami, John P Hussman Inst Human Genom, Coral Gables, FL 33124 USA

 Univ Miami, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL 33124 USA

Pastor, P:
 Univ Navarra Sch Med, Div Neurosci, Ctr Appl Med Res, Neurogenet Lab, Pamplona 28023, Spain

 Univ Navarra Sch Med, Dept Neurol, Univ Navarra Clin, Pamplona, Spain

 Inst Salud Carlos III, CIBERNED, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain

Schmidt, R:
 Med Univ Graz, Dept Neurol, A-8010 Graz, Austria

Rujescu, D:
 Univ Munich, Dept Psychiat, D-80539 Munich, Germany

 Univ Halle, D-80336 Halle, Germany

Dartigues, JF:
 Victor Segalen Univ, Inserm U897, F-33076 Bordeaux, France

 CHU Bordeaux, Ctr Memoire Ressources & Rech Bordeaux, Bordeaux, France

Mayeux, R:
 Columbia Univ, Dept Neurol, Taub Inst Alzheimers Dis & Aging Brain, New York, NY 10027 USA

 Columbia Univ, Dept Neurol, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

Tzourio, C:
 Victor Segalen Univ, Inserm U708, F-33076 Bordeaux, France

Hofman, A:
 Erasmus MC Univ Med Ctr, Dept Epidemiol, NL-3015 CE Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Neurol, NL-3015 CE Rotterdam, Netherlands

 Erasmus MC Univ Med Ctr, Dept Radiol, NL-3015 CE Rotterdam, Netherlands

 Netherlands Consortium Hlth Aging, Leiden, Netherlands

Nothen, MM:
 German Ctr Neurodegenerat Dis DZNE, D-53113 Bonn, Germany

 Univ Bonn, Inst Human Genet, Dept Genom, Life & Brain Ctr, D-53113 Bonn, Germany

Graff, C:
 Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Genet Unit, S-14186 Stockholm, Sweden

 Karolinska Inst, Dept Neurobiol Care Sci & Soc, KIADRC, S-17177 Stockholm, Sweden

Psaty, BM:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA

 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

 Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

 Grp Hlth, Grp Hlth Res Inst, Seattle, WA USA

Haines, JL:
 Vanderbilt Univ, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA

 Vanderbilt Univ, Vanderbilt Ctr Human Genet Res, Nashville, TN 37212 USA

Lathrop, M:
 CEA, Inst Genom, Ctr Natl Genotypage, F-91300 Evry, France

 Fdn Jean Dausset CEPH, F-75010 Paris, France

 McGill Univ, Montreal, PQ, Canada

 Genome Quebec Innovat Ctr, Montreal, PQ, Canada

Pericak-Vance, MA:
 Univ Miami, John P Hussman Inst Human Genom, Coral Gables, FL 33124 USA

 Univ Miami, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL 33124 USA

Launer, LJ:
 Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Genet Unit, S-14186 Stockholm, Sweden

Farrer, LA:
 Boston Univ Sch Med, Dept Med Biomed Genet, Boston, MA 02218 USA

 Boston Univ Sch Med, Dept Ophthalmol, Boston, MA 02215 USA

 Boston Univ Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

 Boston Univ Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA

 Boston Univ Sch Med, Dept Neurol, Boston, MA 02215 USA

van Duijn, CM:
 Erasmus MC Univ Med Ctr, Dept Epidemiol, NL-3015 CE Rotterdam, Netherlands

Van Broeckhoven, C:
 VIB, Dept Mol Genet, Neurodegenerat Brain Dis Grp, B-2000 Antwerp, Belgium

 Univ Antwerp, Inst Born Bunge, Neurogenet Lab, B-2000 Antwerp, Belgium

Ramirez, A:
 Univ Bonn, Dept Psychiat & Psychotherapy, D-53113 Bonn, Germany

 Univ Bonn, Inst Human Genet, D-53113 Bonn, Germany

Schellenberg, GD:
 Univ Penn Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

Seshadri, S:
 Boston Univ Sch Med, Dept Neurol, Boston, MA 02215 USA

Amouyel, P:
 Inserm U744, F-59000 Lille, France

 Univ Lille 2, F-59000 Lille, France

 Inst Pasteur, F-59000 Lille, France

 Funct Genom Ctr, CH-8038 Zurich, Switzerland

 CHRU Lille, F-59037 Lille, France

Williams, J:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Holmans, PA:
 Cardiff Univ, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales

Univ Mississippi Med Ctr, Dept Geriatr Med, Jackson, MS 39216 USA.