Ayahuasca Alters Structural Parameters of the Rat Aorta
Por:
Pitol, DL, Siessere, S, dos Santos, RG, Rosa, MLNM, Hallak, JEC, Scalize, PH, Pereira, BF, Iyomasa, MM, Semprini, M, Riba, J, Regalo, SCH
Publicada:
1 jul 2015
Resumen:
Ayahuasca is a hallucinogenic brew traditionally used by Northwestern Amazonian indigenous groups for therapeutic purposes. It is prepared by the decoction of Banisteriopsis caapi with the leaves of Psychotria viridis. Banisteriopsis caapi contains beta-carbolines that are inhibitors of monoamine oxidase and P. viris is rich in dimethyltryptamine, a 5-HT1A/2A/2C agonist. Acute ayahuasca administration produces moderate cardiovascular effects in healthy volunteers, but information regarding long-term use is lacking. This study investigated the effects of ayahuasca (2-4 mL/kg) in the rat aorta after acute and chronic (14 days) administration. Ayahuasca caused flattening and stretching of vascular smooth muscle cells and changes in the arrangement and distribution of collagen and elastic fibers. Chronic treatment with the higher dose significantly increased media thickness and the ratio of media thickness to lumen diameter. More research is needed on the cardiovascular function of long-term ayahuasca consumers.
Filiaciones:
Pitol, DL:
Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, BR-14049 Ribeirao Preto, Brazil
Siessere, S:
Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, BR-14049 Ribeirao Preto, Brazil
dos Santos, RG:
Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, BR-14049 Ribeirao Preto, Brazil
Rosa, MLNM:
Fac Med Catanduva, Dept Biophysiol Sci, Catanduva, Brazil
Hallak, JEC:
Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Neurosci & Behav, BR-14049 Ribeirao Preto, Brazil
CNPq, Natl Inst Translat Med INCT TM, Ribeirao Preto, Brazil
Scalize, PH:
Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, BR-14049 Ribeirao Preto, Brazil
Pereira, BF:
Biosci Inst Mol & Cellular Biol UNESP, Mol & Cellular Biol Unit, Rio Claro, Brazil
Iyomasa, MM:
Fac Med Catanduva, Dept Biophysiol Sci, Catanduva, Brazil
Semprini, M:
Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, BR-14049 Ribeirao Preto, Brazil
Riba, J:
Hosp Santa Creu & Sant Pau, Ctr Invest Med, Serv Farmacol Clin, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Inst Recerca, Human Expt Neuropsychopharmacol, Barcelona, Spain
Univ Autonoma Barcelona, Dept Farmacol & Terapeut, E-08193 Barcelona, Spain
CIBERSAM, Ctr Invest Biomed Red Salud Mental, Barcelona, Spain
Regalo, SCH:
Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, BR-14049 Ribeirao Preto, Brazil
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