The Response to Biologics is Better in Patients with Severe Asthma Than in Patients with Asthma-COPD Overlap Syndrome
Por:
De Llano, LP, Rivas, DD, Malanda, NM, Moral, VP, Blanco, JAG, Munoz-Esquerre, M, Garcia-Moguel, I, Campos, RMD, Martinez-Moragon, E, Mena, AH, Cosio, BG, Galo, AP, Serrano, CC
Publicada:
1 ene 2022
Resumen:
Although biologics have demonstrated to be effective in T2-high asthma patients, there is little experience with these drugs in asthma-COPD overlap (ACO). The aim of this study was to compare the effectiveness of biologics in these two conditions. We included 318 patients (24 ACO and 297 asthma) treated with monoclonal antibodies and followed for at least 12 months Omalizumab was the most frequently employed biologic agent both in patients with ACO and asthma. Asthma control test (ACT) scores after at least 12 months of biologic therapy were not significantly different between groups. The percentage of patients with >= 1 exacerbation and >= 1 corticosteroid burst was significantly higher in ACO patients (70.8 vs 27.3 and 83.3% vs 37.5%, respectively), whereas the percentage of "controlled" patients (with no exacerbations, no need for corticosteroids and ACT >= 20) was significantly lower (16.7% vs 39.7%). In conclusion, this report suggests that patients with ACO treated with biologics reach worse outcomes than asthma patients.
Filiaciones:
De Llano, LP:
Hosp Lucus Augusti, Pneumol Serv, EOXI Lugo Cervo & Monforte, Lugo, Spain
Rivas, DD:
Hosp Lucus Augusti, Pneumol Serv, EOXI Lugo Cervo & Monforte, Lugo, Spain
Malanda, NM:
Hosp Univ Cruces, Pneumol Serv, Baracaldo, Bizkaia, Spain
Moral, VP:
Hosp Sta Creu & St Pau, Pneumol Serv, Barcelona, Spain
Blanco, JAG:
Univ Hosp San Agustin, Pneumol Serv, Aviles, Spain
Munoz-Esquerre, M:
Hosp Bellvitge IDIBELL, Pneumol Serv, Barcelona, Spain
Garcia-Moguel, I:
Hosp 12 Octubre, Allergy Serv, Madrid, Spain
Campos, RMD:
Hosp Univ 12 Octubre, Inst Hlth Res i 12, Pneumol Serv, Madrid, Spain
Martinez-Moragon, E:
Hosp Doctor Peset, Pneumol Serv, Valencia, Spain
Mena, AH:
Hosp Merida, Allergy Serv, Badajoz, Spain
Cosio, BG:
Hosp Univ Son Espases IdISBa CIBERES, Pneumol Serv, Palma De Mallorca, Spain
Galo, AP:
Hosp Costa del Sol, Pneumol Serv, Malaga, Spain
Serrano, CC:
Hosp Univ La Princesa, Pneumol Serv, Madrid, Spain
gold, Green Published
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