TMAO and Gut Microbial-Derived Metabolites TML and gamma BB Are Not Associated with Thrombotic Risk in Patients with Venous Thromboembolism
Por:
Canyelles, M, Plaza, M, Rotllan, N, Llobet, D, Julve, J, Mojal, S, Diaz-Ricart, M, Soria, JM, Escola-Gil, JC, Tondo, M, Blanco-Vaca, F, Souto, JC
Publicada:
1 mar 2022
Resumen:
Background: The present work evaluates the association between circulating concentrations of Trimethylamine-N-oxide (TMAO), gamma butyrobetaine (gamma BB), and trimetyllisine (TML) in controls and patients with venous thromboembolism (VTE) with coagulation parameters. Methods: The study involved 54 VTE patients and 57 controls. Platelet function, platelet hyperreactivity, platelet adhesiveness, thrombosis-associated parameters, and thrombin generation parameters were studied. Plasma TMAO, gamma BB, and TML determination was performed using an ultra-high-performance liquid chromatography system coupled with mass spectrometry. Results: No differences were found for TMAO, gamma BB, or TML concentrations between controls and VTE patients. In thrombin generation tests, TMAO, gamma BB, and TML showed a positive correlation with lag time and time to peak. TMAO, gamma BB, and TML negatively correlated with peak height. No significant differences were observed regarding TMAO, gamma BB, and TML concentrations between the two blood withdrawals, nor when the control and VTE patients were analyzed separately. No correlation was observed between these gut metabolites and platelet function parameters. Conclusions: No differences were found regarding TMAO, gamma BB, and TML concentrations between the control and VTE groups. Some correlations were found; however, they were mild or went in the opposite direction of what would be expected if TMAO and its derivatives were related to VTE risk.
Filiaciones:
Canyelles, M:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Dept Clin Biochem, IIB St Pau, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Barcelona 08041, Spain
Plaza, M:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Unit Thrombosis & Hemostasis, Barcelona 08041, Spain
Rotllan, N:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
Llobet, D:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Unit Thrombosis & Hemostasis, Barcelona 08041, Spain
Julve, J:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
Mojal, S:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Unit Thrombosis & Hemostasis, Barcelona 08041, Spain
Diaz-Ricart, M:
Univ Barcelona, Hosp Clin Barcelona, Ctr Diagnost Biomed CDB,Dept Pathol, Inst Invest Biomed August Pi & Sunyer IDIBAPS,Hem, Barcelona 08007, Spain
Soria, JM:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, IIB St Pau, Res Inst, Genom Complex Dis Grp, Barcelona 08041, Spain
Escola-Gil, JC:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
Tondo, M:
Hosp Santa Creu & Sant Pau, Dept Clin Biochem, IIB St Pau, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
Blanco-Vaca, F:
Hosp Santa Creu & Sant Pau, Dept Clin Biochem, IIB St Pau, Barcelona 08041, Spain
CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain
Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Barcelona 08041, Spain
Souto, JC:
Hosp Santa Creu & Sant Pau, Inst Invest Biomed IIB St Pau, Inst Recerca, Barcelona 08041, Spain
Hosp Santa Creu & Sant Pau, Unit Thrombosis & Hemostasis, Barcelona 08041, Spain
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