Epidemiological and Genetic Characterization of Norovirus Outbreaks That Occurred in Catalonia, Spain, 2017-2019
Por:
Anfruns-Estrada, E, Sabate, S, Razquin, E, Sanchez, TC, Bartolome, R, Torner, N, Izquierdo, C, Soldevila, N, Coronas, L, Dominguez, A, Fuentes, C, Pinto, RM, Bosch, A, Guix, S
Publicada:
1 mar 2022
Resumen:
Molecular characterization of human norovirus (HuNoV) genotypes enhances the understanding of viral features and illustrates distinctive evolutionary patterns. The aim of our study was to describe the prevalence of the genetic diversity and the epidemiology of the genotypes involved in HuNoV outbreaks in Catalonia (Spain) between 2017 and 2019. A total of 100 HuNoV outbreaks were notified with the predominance of GII (70%), followed by GI (27%) and mixed GI/GII (3%). Seasonality was observed for GII outbreaks only. The most prevalent genotypes identified were GII.4[P31] Sydney 2012, GII.4[P16] Sydney 2012 and GII.2[P16]. As compared to person-to-person (P/P) transmitted outbreaks, foodborne outbreaks showed significantly higher attack rates and lower duration. The average attack rate was higher in youth hostel/campgrounds compared to nursing homes. Only genotypes GI.4[P4], GII.2[P16], GII.4[P16], GII.4[P31] and GII.17[P17] were consistently detected every year, and only abundance of GII.2[P16] showed a negative trend over time. GII.4 Sydney 2012 outbreaks were significantly associated to nursing homes, while GII.2[P16] and GI.3[P3] were most frequently identified in youth hostel/campgrounds. The average attack rate was significantly higher when comparing GII.2[P16] vs. GI.4[P4], GII.2[P16] vs. GII.4[P31] Sydney 2012, and GII.6[P7] vs. GII.4[P31] Sydney 2012. No correlations were found between genotype and outbreak duration or age of affected individuals.
Filiaciones:
Anfruns-Estrada, E:
Univ Barcelona, Dept Genet Microbiol & Stat, Enter Virus Lab, Barcelona 08028, Spain
Univ Barcelona, Nutr & Food Safety Res Inst INSA UB, Santa Coloma De Gramenet 08921, Spain
Sabate, S:
Lab Agencia Salut Publ Barcelona ASPB, Barcelona 08023, Spain
Razquin, E:
Lab Agencia Salut Publ Barcelona ASPB, Barcelona 08023, Spain
Sanchez, TC:
Vall dHebron Univ Hosp, Microbiol Lab, Barcelona 08035, Spain
Bartolome, R:
Vall dHebron Univ Hosp, Microbiol Lab, Barcelona 08035, Spain
Torner, N:
Generalitat Catalonia, Dept Hlth, Barcelona 08005, Spain
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Izquierdo, C:
Generalitat Catalonia, Dept Hlth, Barcelona 08005, Spain
Soldevila, N:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Coronas, L:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Dominguez, A:
Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain
Univ Barcelona, Dept Med, Barcelona 08036, Spain
Fuentes, C:
Univ Barcelona, Dept Genet Microbiol & Stat, Enter Virus Lab, Barcelona 08028, Spain
Univ Barcelona, Nutr & Food Safety Res Inst INSA UB, Santa Coloma De Gramenet 08921, Spain
Pinto, RM:
Univ Barcelona, Dept Genet Microbiol & Stat, Enter Virus Lab, Barcelona 08028, Spain
Univ Barcelona, Nutr & Food Safety Res Inst INSA UB, Santa Coloma De Gramenet 08921, Spain
Bosch, A:
Univ Barcelona, Dept Genet Microbiol & Stat, Enter Virus Lab, Barcelona 08028, Spain
Univ Barcelona, Nutr & Food Safety Res Inst INSA UB, Santa Coloma De Gramenet 08921, Spain
Guix, S:
Univ Barcelona, Dept Genet Microbiol & Stat, Enter Virus Lab, Barcelona 08028, Spain
Univ Barcelona, Nutr & Food Safety Res Inst INSA UB, Santa Coloma De Gramenet 08921, Spain
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