New insights into the genetic etiology of Alzheimer's disease and related dementias


Por: Bellenguez, C, Kucukali, F, Jansen, IE, Kleineidam, L, Moreno-Grau, S, Amin, N, Naj, AC, Campos-Martin, R, Grenier-Boley, B, Andrade, V, Holmans, PA, Boland, A, Damotte, V, van der Lee, SJ, Costa, MR, Kuulasmaa, T, Yang, Q, De Rojas, I, Bis, JC, Yaqub, A, Prokic, I, Chapuis, J, Ahmad, S, Giedraitis, V, Aarsland, D, Garcia-Gonzalez, P, Abdelnour, C, Alarcon-Martin, E, Alcolea, D, Alegret, M, Alvarez, I, Alvarez, V, Armstrong, NJ, Tsolaki, A, Antunez, C, Appollonio, I, Arcaro, M, Archetti, S, Pastor, AA, Arosio, B, Athanasiu, L, Bailly, H, Banaj, N, Baquero, M, Barral, S, Beiser, A, Pastor, AB, Below, JE, Benchek, P, Benussi, L, Berr, C, Besse, C, Bessi, V, Binetti, G, Bizarro, A, Blesa, R, Boada, M, Boerwinkle, E, Borroni, B, Boschi, S, Bossu, P, Brathen, G, Bressler, J, Bresner, C, Brodaty, H, Brookes, KJ, Brusco, LI, Buiza-Rueda, D, Burger, K, Burholt, V, Bush, WS, Calero, M, Cantwell, LB, Chene, G, Chung, J, Cuccaro, ML, Cecchetti, R, Cervera-Carles, L, Charbonnier, C, Chen, HH, Chillotti, C, Ciccone, S, Claassen, JAHR, Clark, C, Conti, E, Corma-Gomez, A, Costantini, E, Custodero, C, Daian, D, Dalmasso, MC, Daniele, A, Dardiotis, E, Dartigues, JF, de Deyn, PP, Lopes, KD, De Witte, LD, Debette, S, Deckert, J, del Ser, T, Denning, N, Destefano, A, Dichgans, M, Diehl-Schmid, J, Diez-Fairen, M, Rossi, PD, Djurovic, S, Duron, E, Duzel, E, Dufouil, C, Eiriksdottir, G, Engelborghs, S, Escott-Price, V, Espinosa, A, Ewers, M, Faber, KM, Fabrizio, T, Nielsen, SF, Fardo, DW, Farotti, L, Fenoglio, C, Fernandez-Fuertes, M, Ferrari, R, Ferreira, CB, Ferri, E, Fin, B, Fischer, P, Fladby, T, Fliessbach, K, Fongang, B, Fornage, M, Fortea, J, Foroud, TM, Fostinelli, S, Fox, NC, Franco-Macias, E, Bullido, MJ, Frank-Garcia, A, Froelich, L, Fulton-Howard, B, Galimberti, D, Garcia-Alberca, JM, Garcia-Madrona, S, Garcia-Ribas, G, Ghidoni, R, Giegling, I, Giorgio, G, Goate, AM, Goldhardt, O, Gomez-Fonseca, D, Gonzalez-Perez, A, Graff, C, Grande, G, Green, E, Grimmer, T, Grunblatt, E, Grunin, M, Gudnason, V, Guetta-Baranes, T, Haapasalo, A, Hadjigeorgiou, G, Haines, JL, Hamilton-Nelson, KL, Hampel, H, Hanon, O, Hardy, J, Hartmann, AM, Hausner, L, Harwood, J, Heilmann-Heimbach, S, Helisalmi, S, Heneka, MT, Hernandez, I, Herrmann, MJ, Hoffmann, P, Holmes, C, Holstege, H, Vilas, RH, Hulsman, M, Humphrey, J, Biessels, GJ, Jian, XQ, Johansson, C, Jun, GR, Kastumata, Y, Kauwe, J, Kehoe, PG, Kilander, L, Stahlbom, AK, Kivipelto, M, Koivisto, A, Kornhuber, J, Kosmidis, MH, Kukull, WA, Kuksa, PP, Kunkle, BW, Kuzma, AB, Lage, C, Laukka, EJ, Launer, L, Lauria, A, Lee, CY, Lehtisalo, J, Lerch, O, Lleo, A, Longstreth, W, Lopez, O, de Munain, AL, Love, S, Lowemark, M, Luckcuck, L, Lunetta, KL, Ma, YY, Macias, J, Macleod, CA, Maier, W, Mangialasche, F, Spallazzi, M, Marquie, M, Marshall, R, Martin, ER, Montes, AM, Rodriguez, CM, Masullo, C, Mayeux, R, Mead, S, Mecocci, P, Medina, M, Meggy, A, Mehrabian, S, Mendoza, S, Menendez-Gonzalez, M, Mir, P, Moebus, S, Mol, M, Molina-Porcel, L, Montrreal, L, Morelli, L, Moreno, F, Morgan, K, Mosley, T, Nothen, MM, Muchnik, C, Mukherjee, S, Nacmias, B, Ngandu, T, Nicolas, G, Nordestgaard, BG, Olaso, R, Orellana, A, Orsini, M, Ortega, G, Padovani, A, Paolo, C, Papenberg, G, Parnetti, L, Pasquier, F, Pastor, P, Peloso, G, Perez-Cordon, A, Perez-Tur, J, Pericard, P, Peters, O, Pijnenburg, YAL, Pineda, JA, Pinol-Ripoll, G, Pisanu, L, Polak, T, Popp, J, Posthuma, D, Priller, J, Puerta, R, Quenez, O, Quintela, I, Thomassen, JQ, Rabano, A, Rainero, I, Rajabli, F, Ramakers, I, Real, LM, Reinders, MJT, Reitz, C, Reyes-Dumeyer, D, Ridge, P, Riedel-Heller, S, Riederer, P, Roberto, N, Rodriguez-Rodriguez, E, Rongve, A, Allende, IR, Rosende-Roca, M, Royo, JL, Rubino, E, Rujescu, D, Saez, ME, Sakka, P, Saltvedt, I, Sanchez-Arjona, MB, Sanchez-Garcia, F, Juan, PS, Sanchez-Valle, R, Sando, SB, Sarnowski, C, Satizabal, CL, Scamosci, M, Scarmeas, N, Scarpini, E, Scheltens, P, Scherbaum, N, Scherer, M, Schmid, M, Schneider, A, Schott, JM, Selbaek, G, Seripa, D, Serrano, M, Sha, J, Shadrin, AA, Skrobot, O, Slifer, S, Snijders, GJL, Soininen, H, Solfrizzi, V, Solomon, A, Song, Y, Sorbi, S, Sotolongo-Grau, O, Spalletta, G, Spottke, A, Squassina, A, Stordal, E, Tartan, JP, Tarraga, L, Tesi, N, Thalamuthu, A, Thomas, T, Tosto, G, Traykov, L, Tremolizzo, L, Tybjaeg-Hansen, A, Uitterlinden, A, Ullgren, A, Ulstein, I, Valero, S, Valladares, O, Van Broeckhoven, C, Vance, J, Vardarajan, BN, van der Lugt, A, Van Dongen, J, van Rooij, J, van Swieten, J, Vandenberghe, R, Verhey, F, Vidal, JS, Vogelgsang, J, Vyhnalek, M, Wagner, M, Wallon, D, Wang, LS, Wang, RQ, Weinhold, L, Wiltfang, J, Windle, G, Woods, B, Yannakoulia, M, Zare, H, Zhao, Y, Zhang, XL, Zhu, CC, Zulaica, M, Farrer, LA, Psaty, BM, Ghanbari, M, Raj, T, Sachdev, P, Mather, K, Jessen, F, Ikram, MA, de Mendonca, A, Hort, J, Tsolaki, M, Pericak-Vance, MA, Amouyel, P, Williams, J, Frikke-Schmidt, R, Clarimon, J, Deleuze, JF, Rossi, G, Seshadri, S, Andreassen, OA, Ingelsson, M, Hiltunen, M, Sleegers, K, Schellenberg, GD, van Duijn, CM, Sims, R, van der Flier, WM, Ruiz, A, Ramirez, A, Lambert, JC

Publicada: 1 abr 2022 Ahead of Print: 1 abr 2022
Resumen:
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE epsilon 4 allele. Meta-analysis of genome-wide association studies on Alzheimer's disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer's disease and dementia.

Filiaciones:
Bellenguez, C:
 Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France

Kucukali, F:
 VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium

 Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium

 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium

Jansen, IE:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

 Vrije Univ, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands

Kleineidam, L:
 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

 Univ Cologne, Med Fac, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

Moreno-Grau, S:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Amin, N:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

Naj, AC:
 Univ Penn, Perelman Sch Med, Penn Neurodegenerat Genom Ctr, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Campos-Martin, R:
 Univ Cologne, Med Fac, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany

Grenier-Boley, B:
 Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France

Andrade, V:
 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

 Univ Cologne, Med Fac, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany

Holmans, PA:
 Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

Boland, A:
 Univ Paris Saclay, CEA, Ctr Natl Rech Genom Humaine, Evry, France

Damotte, V:
 Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France

van der Lee, SJ:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

 Vrije Univ Amsterdam, Dept Human Genet Amsterdam UMC, Sect Genom Neurodegenerat Dis & Aging, Amsterdam UMC, Amsterdam, Netherlands

Costa, MR:
 Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France

 Univ Fed Rio Grande do Norte, Brain Inst, Natal, RN, Brazil

Kuulasmaa, T:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

Yang, Q:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

 Framingham Heart Dis Epidemiol Study, Framingham, MA USA

De Rojas, I:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Bis, JC:
 Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

Yaqub, A:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

Prokic, I:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

Chapuis, J:
 Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France

Ahmad, S:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

 LACDR, Leiden, Netherlands

Giedraitis, V:
 Uppsala Univ, Dept Publ Hlth & Carins Sci Geriatr, Uppsala, Sweden

Aarsland, D:
 Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway

 Inst Psychiat Psychol & Neurosci, London, England

Garcia-Gonzalez, P:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Abdelnour, C:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Alarcon-Martin, E:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Univ Malaga, Sch Med, Dept Surg Biochem & Mol Biol, Malaga, Spain

Alcolea, D:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Autanoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

Alegret, M:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Alvarez, I:
 Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Terrassa, Spain

 Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Terrassa, Spain

 Hosp Univ Mutua Terrassa, Dept Neurol, Memory Disorders Unit, Terrassa, Spain

Alvarez, V:
 Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain

 Hosp Univ Cent Asturias Oviedo, Serv Neurol, Oviedo, Spain

 Inst Invest Biosanitaria Principado Asturias, Oviedo, Spain

Armstrong, NJ:
 Univ New South Wales, Fac Med, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

Tsolaki, A:
 Aristotle Univ Thessaloniki, Med Sch, Dept Neurol 1, Thessaloniki, Greece

 Alzheimer Hellas, Thessaloniki, Greece

Antunez, C:
 Hosp Clin Univ Virgen de la Arrixaca, Unidad Demencias, Murcia, Spain

Appollonio, I:
 Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

 San Gerardo Hosp, Neurol Unit, Monza, Italy

Arcaro, M:
 Osped Policlin, Fdn IRCCS Ca Granda, Milan, Italy

Archetti, S:
 Brescia Hosp, Dept Lab Diagnost, Lab Anal 3, Brescia, Italy

Pastor, AA:
 Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain

 Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain

Arosio, B:
 Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

 IRCCS Osped Maggiore Policlin, Geriat Unit, Fdn Ca Granda, Milan, Italy

Athanasiu, L:
 Univ Oslo, NORMENT Ctr, Oslo, Norway

Bailly, H:
 Univ Paris, EA 4468, Hop Broca, AP HP, Paris, France

Banaj, N:
 IrCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Rome, Italy

Baquero, M:
 Hosp Univ & Politecn La Fe, Serv Neurol, Valencia, Spain

Barral, S:
 Columbia Univ, Taub Inst Alzheimer S Dis & Aging Brain, Dept Neurol, New York, NY USA

 Univ Parma, Unit Neurol, Parma, Italy

 AOU, Parma, Italy

 Med Univ Sofia, UH Alexandrovska, Clin Neurol, Sofia, Bulgaria

Beiser, A:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

 Boston Univ, Boston, MA 02215 USA

 NHLBIs Framingham Heart Study, Boston, MA USA

Pastor, AB:
 CIEN Fdn Queen Sofia Fdn Alzheimer Ctr, Madrid, Spain

Below, JE:
 Vanderbilt Univ, Vanderbilt Brain Inst, 221 Kirkland Hall, Nashville, TN 37235 USA

Benchek, P:
 Case Western Reserve Univ, Cleveland Inst Computat Biol, Cleveland, OH 44106 USA

 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

Benussi, L:
 IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

Berr, C:
 Univ Montpellier, INSERM U1061, PSNREC, Neuropsychiat Epidemiol & Clin Res, Montpellier, France

Besse, C:
 Univ Paris Saclay, CEA, Ctr Natl Rech Genom Humaine, Evry, France

Bessi, V:
 Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

 Azienda Osped Univ Careggi, Florence, Italy

Binetti, G:
 IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

 IRCCS Ist Ctr San Giovanni di Dio Fatebenefratel, MAC Memory Clin, Brescia, Italy

Bizarro, A:
 Fdn Policlin A Gemelli IrCCS, Geriatr Unit, Rome, Italy

Blesa, R:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Autanoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

Boada, M:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Boerwinkle, E:
 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA

 Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

Borroni, B:
 Univ Brescia, Ctr Neurodegenerat Disorders, Dept Clin & Expt Sci, Brescia, Italy

Boschi, S:
 Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy

Bossu, P:
 IrCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Expt Neuropsychobiol Lab, Rome, Italy

Brathen, G:
 Univ Hosp Trondheim, Dept Neurol & Clin Neurophysiol, Trondheim, Norway

 Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Trondheim, Norway

Bressler, J:
 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA

 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX 77030 USA

Bresner, C:
 Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

Brodaty, H:
 Univ New South Wales, Fac Med, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

 Univ New South Wales, Dementia Ctr Res Collaborat, Sch Psychiat, Sydney, NSW, Australia

Brookes, KJ:
 Nottingham Trent Univ, Sch Sci & Technol, Biosci, Nottingham, England

Brusco, LI:
 Univ Buenos Aires UBA, Fac Med, Ctr Neuropsiquiatr & Neurol Conducta CENECON, Buenos Aires, DF, Argentina

 UBA, Dept Ciencias Fisiol UAII, Fac Med, Buenos Aires, DF, Argentina

 Hosp Interzonal Gen Agudos Eva Peron, Buenos Aires, DF, Argentina

Buiza-Rueda, D:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Erasmus MC, Dept Neurol, Rotterdam, Netherlands

Burger, K:
 Ludwig Maximilians Univ LMU, Inst Stroke & Dementia Res, Klinikum Univ Munchen, Munich, Germany

 German Ctr Neurodegenerat Dis DZNE, Munich, Germany

Burholt, V:
 Univ Auckland, Fac Med & Hlth Sci, Auckland, New Zealand

 Swansea Univ, Wales Ctr Ageing & Dementia Res, Swansea, W Glam, Wales

Bush, WS:
 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

Calero, M:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 CIEN Fdn Queen Sofia Fdn Alzheimer Ctr, Madrid, Spain

 Inst Salud Carlos III, UFIEC, Madrid, Spain

Cantwell, LB:
 Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA

Chene, G:
 Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, UMR 1219,ISPED,CIC 1401 EC, Bordeaux, France

 CHU Bordeaux, Pole Sante Publ, Bordeaux, France

Chung, J:
 Boston Univ, Sch Med, Med Biomed Genet, Boston, MA 02118 USA

Cuccaro, ML:
 Univ Miami, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL USA

 Univ Santiago de Compostela, Fdn Publ Galega Med Xen CIBERER IDIS, Santiago De Compostela, Spain

Cecchetti, R:
 Univ Perugia, Inst Gerontol & Geriatr, Dept Med & Surg, Perugia, Italy

Cervera-Carles, L:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Autanoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

Charbonnier, C:
 Normandie Univ, Dept Genet, CHU Rouen, UNIROUEN,INSERM U1245, Rouen, France

 Normandie Univ, CNR MAJ, UNIROUEN, INSERM U1245,CHU Rouen, Rouen, France

Chen, HH:
 Vanderbilt Univ, Div Genet Med, 221 Kirkland Hall, Nashville, TN 37235 USA

Chillotti, C:
 Univ Hosp Cagliari, Unit Clin Pharmacol, Cagliari, Italy

Ciccone, S:
 IRCCS Osped Maggiore Policlin, Geriat Unit, Fdn Ca Granda, Milan, Italy

Claassen, JAHR:
 Radboud Univ Nijmegen Med Ctr, Radboudumc Alzheimer Ctr, Dept Geriatr, Nijmegen, Netherlands

Clark, C:
 Univ Zurich, Inst Regenerat Med, Schlieren, Switzerland

Conti, E:
 Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

Corma-Gomez, A:
 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain

Costantini, E:
 Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IrCCS, Dept Neurosci, Rome, Italy

Custodero, C:
 Univ Bari A Moro, Bary, Italy

Daian, D:
 Univ Paris Saclay, CEA, Ctr Natl Rech Genom Humaine, Evry, France

Dalmasso, MC:
 Univ Cologne, Med Fac, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany

Daniele, A:
 Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IrCCS, Dept Neurosci, Rome, Italy

Dardiotis, E:
 Univ Thessaly, Sch Med, Larisa, Greece

Dartigues, JF:
 Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, Bordeaux, France

de Deyn, PP:
 Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands

Lopes, KD:
 Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Icahn Inst Data Sci & Genom Technol, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Estelle & Daniel Maggin Dept Neurol, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

De Witte, LD:
 Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

Debette, S:
 Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, Bordeaux, France

Deckert, J:
 Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

del Ser, T:
 CIEN Fdn Queen Sofia Fdn Alzheimer Ctr, Madrid, Spain

Denning, N:
 Cardiff Univ, Sch Med, UKDRI Cardiff, Cardiff, Wales

Destefano, A:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

Dichgans, M:
 Ludwig Maximilians Univ LMU, Inst Stroke & Dementia Res, Klinikum Univ Munchen, Munich, Germany

 Munich Cluster Syst Neurol SyNergy, Munich, Germany

Diehl-Schmid, J:
 Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany

Diez-Fairen, M:
 Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Terrassa, Spain

 Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Terrassa, Spain

 Hosp Univ Mutua Terrassa, Dept Neurol, Memory Disorders Unit, Terrassa, Spain

Rossi, PD:
 IRCCS Osped Maggiore Policlin, Geriat Unit, Fdn Ca Granda, Milan, Italy

Djurovic, S:
 Univ Oslo, NORMENT Ctr, Oslo, Norway

Duron, E:
 Univ Paris, EA 4468, Hop Broca, AP HP, Paris, France

Duzel, E:
 Otto Von Guericke Univ, Inst Cognit Neurol & Dementia Res IKND, Magdeburg, Germany

 German Ctr Neurodegenerat Dis DZNE, Magdeburg, Germany

Dufouil, C:
 Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, UMR 1219,ISPED,CIC 1401 EC, Bordeaux, France

 CHU Bordeaux, Pole Sante Publ, Bordeaux, France

Eiriksdottir, G:
 Iceland Heart Assoc, Kopovagur, Iceland

Engelborghs, S:
 Vrije Univ Brussel VUB, Ctr Neurosci, Brussels, Belgium

 Univ Antwerp, Reference Ctr Biol Markers Dementia BIODEM, Inst Born Bunge, Antwerp, Belgium

 Univ Antwerp, Inst Born Bunge, Antwerp, Belgium

 UZ Brussel, Dept Neurol, Brussels, Belgium

Escott-Price, V:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

 Cardiff Univ, Sch Med, UKDRI Cardiff, Cardiff, Wales

Espinosa, A:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Ewers, M:
 Ludwig Maximilians Univ LMU, Inst Stroke & Dementia Res, Klinikum Univ Munchen, Munich, Germany

 German Ctr Neurodegenerat Dis DZNE, Munich, Germany

Faber, KM:
 Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN USA

Fabrizio, T:
 Ist Neurol Carlo Besta, Fdn IRCCS, Milan, Italy

Nielsen, SF:
 Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark

Fardo, DW:
 Univ Kentucky, Sanders Brown Ctr Aging, Dept Biostat, Lexington, KY USA

Farotti, L:
 Univ Perugia, Ctr Memory Disturbances, Sect Neurol, Lab Clin Neurochem, Perugia, Italy

Fenoglio, C:
 Univ Milan, Milan, Italy

Fernandez-Fuertes, M:
 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain

Ferrari, R:
 Texas Tech Univ, Dept Internal Med, Lab Neurogenet, Hlth Sci Ctr, Lubbock, TX USA

 UCL Inst Neurol, Dept Mol Neurosci, Reta Lila Weston Res Labs, London, England

Ferreira, CB:
 Univ Lisbon, Fac Med, Lisbon, Portugal

Ferri, E:
 IRCCS Osped Maggiore Policlin, Geriat Unit, Fdn Ca Granda, Milan, Italy

Fin, B:
 Univ Paris Saclay, CEA, Ctr Natl Rech Genom Humaine, Evry, France

Fischer, P:
 Social Med Ctr East Donauspital, Dept Psychiat, Vienna, Austria

Fladby, T:
 Univ Oslo, Inst Clin Med, Oslo, Norway

Fliessbach, K:
 Univ Cologne, Med Fac, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

Fongang, B:
 Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

Fornage, M:
 Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Trondheim, Norway

 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Houston, TX 77030 USA

Fortea, J:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Autanoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

Foroud, TM:
 Indiana Univ, Dept Med & Mol Genet, Indianapolis, IN USA

Fostinelli, S:
 IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

Fox, NC:
 UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

Franco-Macias, E:
 Hosp Univ Virgen del Rocio CSIC Univ Sevilla, Unidad Demencias, Inst Biomed Sevilla IBiS, Serv Neurol & Neurofisiol, Seville, Spain

Bullido, MJ:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain

 Ctr Biol Mol Severo Ochoa UAM CSIC, Madrid, Spain

Frank-Garcia, A:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain

 Hosp Univ La Paz, Madrid, Spain

Froelich, L:
 Cent Inst Mental Hlth, Dept Geriatr Psychiat, Mannheim, Germany

 Heidelberg Univ, Heidelberg, Germany

Fulton-Howard, B:
 Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, Dept Genet & Genom Sci, New York, NY 10029 USA

Galimberti, D:
 Osped Policlin, Fdn IRCCS Ca Granda, Milan, Italy

 Univ Milan, Milan, Italy

Garcia-Alberca, JM:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain

 Andalusian Inst Neurosci, Memory Clin, Malaga, Spain

Garcia-Madrona, S:
 Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain

Garcia-Ribas, G:
 Hosp Univ Ramon y Cajal, IRYCIS, Madrid, Spain

Ghidoni, R:
 IRCCS Ist Ctr San Giovanni di Dio Fatebenefratell, Mol Markers Lab, Brescia, Italy

Giegling, I:
 Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria

Giorgio, G:
 Ist Neurol Carlo Besta, Fdn IRCCS, Milan, Italy

Goate, AM:
 Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, Dept Genet & Genom Sci, New York, NY 10029 USA

Goldhardt, O:
 Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany

Gomez-Fonseca, D:
 Univ Penn, Dept Biostat Epidemiol & Informat, Perelman Sch Med, Philadelphia, PA 19104 USA

Gonzalez-Perez, A:
 Ctr Andaluz Estudios Bioinformat, CAEBI, Seville, Spain

Graff, C:
 Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden

 Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Stockholm, Sweden

Grande, G:
 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

 Stockholm Univ, Stockholm, Sweden

Green, E:
 Univ Cambridge, Inst Publ Hlth, Cambridge, England

Grimmer, T:
 Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany

Grunblatt, E:
 Univ Zurich, Univ Hosp Psychiat Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland

 Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

 Swiss Fed Inst Technol, Zurich, Switzerland

 Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

Grunin, M:
 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

Gudnason, V:
 Univ Iceland, Fac Med, Iceland Heart Assoc, Reykjavik, Iceland

Guetta-Baranes, T:
 Univ Nottingham, Sch Life Sci, Human Genet, Life Sci Bldg,Univ Pk, Nottingham, England

Haapasalo, A:
 Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland

Hadjigeorgiou, G:
 Univ Cyprus, Med Sch, Dept Neurol, Nicosia, Cyprus

Haines, JL:
 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

Hamilton-Nelson, KL:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

Hampel, H:
 Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, GRC 21,Alzheimer Precis Med Initiat APMI, Paris, France

Hanon, O:
 Univ Paris, EA 4468, Hop Broca, AP HP, Paris, France

Hardy, J:
 UCL Inst Neurol, Dept Mol Neurosci, Reta Lila Weston Res Labs, London, England

Hartmann, AM:
 Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria

Hausner, L:
 Cent Inst Mental Hlth, Dept Geriatr Psychiat, Mannheim, Germany

 Heidelberg Univ, Heidelberg, Germany

Harwood, J:
 Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

Heilmann-Heimbach, S:
 Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany

 Univ Hosp Bonn, Bonn, Germany

Helisalmi, S:
 Univ Eastern, Inst Clin Med, Neurol, Kuopio, Finland

 Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio, Finland

Heneka, MT:
 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

Hernandez, I:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Herrmann, MJ:
 Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

Hoffmann, P:
 Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany

 Univ Hosp Bonn, Bonn, Germany

Holmes, C:
 Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, Hants, England

Holstege, H:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

 Vrije Univ Amsterdam, Dept Human Genet Amsterdam UMC, Sect Genom Neurodegenerat Dis & Aging, Amsterdam UMC, Amsterdam, Netherlands

Vilas, RH:
 Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain

 Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain

Hulsman, M:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

 Vrije Univ Amsterdam, Dept Human Genet Amsterdam UMC, Sect Genom Neurodegenerat Dis & Aging, Amsterdam UMC, Amsterdam, Netherlands

Humphrey, J:
 Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Icahn Inst Data Sci & Genom Technol, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Estelle & Daniel Maggin Dept Neurol, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA

Biessels, GJ:
 UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Jian, XQ:
 Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

Johansson, C:
 Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden

Jun, GR:
 Boston Univ, Sch Med, Med Biomed Genet, Boston, MA 02118 USA

Kastumata, Y:
 Univ Kentucky, Coll Publ Hlth, Biostat, Lexington, KY USA

Kauwe, J:
 Brigham Young Univ, Dept Biol, Provo, UT 84602 USA

Kehoe, PG:
 Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Bristol, Avon, England

Kilander, L:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

Stahlbom, AK:
 Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden

Kivipelto, M:
 Karolinska Inst, Ctr Alzheimer Res Care Sci & Soc NVS, Div Clin Geriatr, Stockholm, Sweden

 Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland

 Imperial Coll London, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, London, England

 UnitStockholms Sjukhem, Res & Dev, Stockholm, Sweden

Koivisto, A:
 Univ Eastern, Inst Clin Med, Neurol, Kuopio, Finland

 Kuopio Univ Hosp, Dept Neurol, Kuopio, Finland

 Univ Helsinki, Dept Neurosci, Helsinki, Finland

 Helsinki Univ Hosp, Dept Geriatr, Helsinki, Finland

Kornhuber, J:
 Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany

 Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany

Kosmidis, MH:
 Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Greece

Kukull, WA:
 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

Kuksa, PP:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Kunkle, BW:
 Univ Cyprus, Med Sch, Dept Neurol, Nicosia, Cyprus

Kuzma, AB:
 Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA

Lage, C:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, Santander, Spain

 IDIVAL, Santander, Spain

Laukka, EJ:
 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

 Stockholm Univ, Stockholm, Sweden

 Stockholm Gerontol Res Ctr, Stockholm, Sweden

Launer, L:
 NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA

 NIA, Intramural Res Program, NIH, Bethesda, MD 20892 USA

Lauria, A:
 Fdn Policlin A Gemelli IrCCS, Geriatr Unit, Rome, Italy

Lee, CY:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Lehtisalo, J:
 Univ Eastern, Inst Clin Med, Neurol, Kuopio, Finland

 Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland

Lerch, O:
 Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic

 Motol Univ Hosp, Prague, Czech Republic

 St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic

Lleo, A:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Autanoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

Longstreth, W:
 Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

 Univ Washington, Dept Neurol, Seattle, WA USA

Lopez, O:
 Framingham Heart Dis Epidemiol Study, Framingham, MA USA

de Munain, AL:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Hosp Univ Donostia, Dept Neurol, OSAKIDETZA Serv Vasco Salud, San Sebastian, Spain

Love, S:
 Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Bristol, Avon, England

Lowemark, M:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

Luckcuck, L:
 Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

Lunetta, KL:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

Ma, YY:
 Vrije Univ Amsterdam, Dept Human Genet Amsterdam UMC, Sect Genom Neurodegenerat Dis & Aging, Amsterdam UMC, Amsterdam, Netherlands

 Columbia Univ, Dept Neurol, New York, NY USA

Macias, J:
 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain

Macleod, CA:
 Bangor Univ, Sch Hlth Sci, Bangor, Gwynedd, Wales

Maier, W:
 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

Mangialasche, F:
 Karolinska Inst, Ctr Alzheimer Res Care Sci & Soc NVS, Div Clin Geriatr, Stockholm, Sweden

Spallazzi, M:
 Univ Parma, Unit Neurol, Parma, Italy

 AOU, Parma, Italy

Marquie, M:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Marshall, R:
 Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

Martin, ER:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

Montes, AM:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Inst Invest Sanitaria Hosp La Paz IdiPaz, Madrid, Spain

 Hosp Univ La Paz, Madrid, Spain

Rodriguez, CM:
 Hosp Univ Cent Asturias Oviedo, Serv Neurol, Oviedo, Spain

 Inst Invest Biosanitaria Principado Asturias, Oviedo, Spain

Masullo, C:
 Univ Cattolica Sacro Cuore, Inst Neurol, Rome, Italy

Mayeux, R:
 Columbia Univ, Taub Inst Alzheimer S Dis & Aging Brain, Dept Neurol, New York, NY USA

 Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

Mead, S:
 UCL, UCL Inst Prion Dis, MRC Prion Unit, London, England

Mecocci, P:
 Univ Perugia, Inst Gerontol & Geriatr, Dept Med & Surg, Perugia, Italy

Medina, M:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 CIEN Fdn Queen Sofia Fdn Alzheimer Ctr, Madrid, Spain

Meggy, A:
 Cardiff Univ, Sch Med, UKDRI Cardiff, Cardiff, Wales

Mehrabian, S:
 Med Univ Sofia, UH Alexandrovska, Clin Neurol, Sofia, Bulgaria

Mendoza, S:
 Andalusian Inst Neurosci, Alzheimer Res Ctr, Malaga, Spain

 Andalusian Inst Neurosci, Memory Clin, Malaga, Spain

Menendez-Gonzalez, M:
 Hosp Univ Cent Asturias Oviedo, Serv Neurol, Oviedo, Spain

 Inst Invest Biosanitaria Principado Asturias, Oviedo, Spain

Mir, P:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Hosp Univ Virgen del Rocoo CSIC Univ Sevilla, Unidad Trastornos Movimiento, Serv Neurol & Neurofisiol, Inst Biomed Sevilla IBiS, Seville, Spain

Moebus, S:
 Univ Hosp Univ Duisburg Essen, Inst Urban Publ Hlth, Essen, Germany

Mol, M:
 Erasmus MC, Dept Neurol, Rotterdam, Netherlands

Molina-Porcel, L:
 Inst Invest Biomed August Pi & Sunyer, Neurol Tissue Bank Biobanc, Hosp Clin, IDIBAPS, Barcelona, Spain

 Hosp Clin Barcelona, Neurol Dept, Alzheimers Dis & Other Cognit Disorders Unit, Barcelona, Spain

Montrreal, L:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

Morelli, L:
 FIL CONICET, Lab Brain Aging & Neurodegenerat, Buenos Aires, DF, Argentina

Moreno, F:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Hosp Univ Donostia, Dept Neurol, OSAKIDETZA Serv Vasco Salud, San Sebastian, Spain

Morgan, K:
 Univ Nottingham, Sch Life Sci, Human Genet, Life Sci Bldg,Univ Pk, Nottingham, England

Mosley, T:
 Univ Mississippi Med Ctr, Memory Impairment & Neurodegenerat Dementia MIND, Jackson, MS USA

Nothen, MM:
 Univ Bonn, Sch Med, Inst Human Genet, Bonn, Germany

 Univ Hosp Bonn, Bonn, Germany

Muchnik, C:
 Univ Buenos Aires UBA, Fac Med, Ctr Neuropsiquiatr & Neurol Conducta CENECON, Buenos Aires, DF, Argentina

 UBA, Inst Invest Med A Lanari, Lab Bioquim Mol, Fac Med, Buenos Aires, DF, Argentina

Mukherjee, S:
 Univ Washington, Dept Med, Seattle, WA USA

Nacmias, B:
 Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

 IRCCS Fdn Don Carlo Gnocchi, Florence, Italy

Ngandu, T:
 Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland

Nicolas, G:
 Normandie Univ, Dept Genet, CHU Rouen, UNIROUEN,INSERM U1245, Rouen, France

 Normandie Univ, CNR MAJ, UNIROUEN, INSERM U1245,CHU Rouen, Rouen, France

Nordestgaard, BG:
 Herlev & Gentofte Hosp, Dept Clin Biochem, Herlev, Denmark

 Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

Olaso, R:
 Univ Paris Saclay, CEA, Ctr Natl Rech Genom Humaine, Evry, France

Orellana, A:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Orsini, M:
 Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IrCCS, Dept Neurosci, Rome, Italy

Ortega, G:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Padovani, A:
 Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA

Paolo, C:
 Univ Parma, DIMEC, Parma, Italy

Papenberg, G:
 Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden

 Stockholm Univ, Stockholm, Sweden

Parnetti, L:
 Univ Perugia, Ctr Memory Disturbances, Sect Neurol, Lab Clin Neurochem, Perugia, Italy

Pasquier, F:
 LicendUniv Lille, Resources & Res Memory Ctr MrrC Distalz, UMR1172, CHU Lille,INSERM, Lille, France

Pastor, P:
 Univ Hosp Mutua Terrassa, Dept Neurol, Fundacio Docencia & Recerca Mutua Terrassa, Terrassa, Spain

 Univ Hosp Mutua Terrassa, Dept Neurol, Movement Disorders Unit, Terrassa, Spain

 Hosp Univ Mutua Terrassa, Dept Neurol, Memory Disorders Unit, Terrassa, Spain

Peloso, G:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

 Boston Univ, Boston, MA 02215 USA

 NHLBIs Framingham Heart Study, Boston, MA USA

Perez-Cordon, A:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

Perez-Tur, J:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Inst Biomed Valencia CSIC CIBERNED, Valencia, Spain

 Inst Invest Sanitaria La Fe, Unitat Mixta Neurol & Genet, Valencia, Spain

Pericard, P:
 Univ Lille, US 41 UMS 2014 PLBS, Bilille, CNRS,INSERM,CHU Lille,Inst Pasteur, Lille, France

Peters, O:
 Charite Univ Med Berlin, Inst Psychiat & Psychotherapy, Berlin, Germany

 Free Univ Berlin, Berlin, Germany

 Humboldt Univ, Berlin, Germany

 Berlin Inst Hlth, Berlin, Germany

 German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

Pijnenburg, YAL:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

Pineda, JA:
 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain

Pinol-Ripoll, G:
 Hosp Univ Santa Maria Lleida, Unitat Trastorns Cognitius, Lleida, Spain

 Inst Recerca Biomed Lleida IRBLLeida, Lleida, Spain

Pisanu, L:
 Univ Cagliari, Dept Biomed Sci, Cagliari, Italy

Polak, T:
 Univ Hosp, Ctr Mental Hlth, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

Popp, J:
 CHU Vaudois, Old Age Psychiat, Dept Psychiat, Lausanne, Switzerland

 Lausanne Univ Hosp, Dept Psychiat, Old Age Psychiat, Lausanne, Switzerland

 Univ Hosp Psychiat Zurich, Dept Geriatr Psychiat, Zurich, Switzerland

Posthuma, D:
 Vrije Univ, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Dept Complex Trait Genet, Amsterdam, Netherlands

Priller, J:
 German Ctr Neurodegenerat Dis DZNE, Berlin, Germany

 Charite, Dept Neuropsychiat & Lab Mol Psychiat, Charitepl 1, Berlin, Germany

Puerta, R:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

Quenez, O:
 Normandie Univ, Dept Genet, CHU Rouen, UNIROUEN,INSERM U1245, Rouen, France

 Normandie Univ, CNR MAJ, UNIROUEN, INSERM U1245,CHU Rouen, Rouen, France

Quintela, I:
 Univ Santiago de Compostela, Ctr Nacl Genotipado CEGEN PRB3 ISCIII, Grp Med Xen, Santiago De Compostela, Spain

Thomassen, JQ:
 Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

Rabano, A:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 CIEN Fdn Queen Sofia Fdn Alzheimer Ctr, Madrid, Spain

Rainero, I:
 Univ Brescia, Ctr Neurodegenerat Disorders, Dept Clin & Expt Sci, Brescia, Italy

Rajabli, F:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

Ramakers, I:
 Maastricht Univ, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

Real, LM:
 Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain

 Univ Malaga, Fac Med, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain

Reinders, MJT:
 Delft Univ Technol, Delft Bioinformat Lab, Delft, Netherlands

Reitz, C:
 Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10027 USA

 Delft Univ Technol, Delft Bioinformat Lab, Delft, Netherlands

 Columbia Univ, Taub Inst, New York, NY USA

Reyes-Dumeyer, D:
 Columbia Univ, Dept Neurol, New York, NY USA

 Columbia Univ, Taub Inst, New York, NY USA

Ridge, P:
 Brigham Young Univ, Coll Life Sci, Bioinformat, Provo, UT 84602 USA

Riedel-Heller, S:
 Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth, Leipzig, Germany

Riederer, P:
 Univ Hosp Wurzburg, Ctr Mental Hlth, Clin & Policlin Psychiat Psychosomat & Psychother, Wurzburg, Germany

Roberto, N:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

Rodriguez-Rodriguez, E:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, Santander, Spain

 IDIVAL, Santander, Spain

Rongve, A:
 Helse Fonna Haugesund Hosp, Dept Res & Innovat, Haugesund, Norway

 Univ Bergen, Inst Clin Med K1, Bergen, Norway

Allende, IR:
 Hosp Univ Cent Asturias, Lab Genet, Oviedo, Spain

 Hosp Univ Cent Asturias Oviedo, Serv Neurol, Oviedo, Spain

 Inst Invest Biosanitaria Principado Asturias, Oviedo, Spain

Rosende-Roca, M:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Royo, JL:
 Univ Malaga, Sch Med, Dept Especialidades Quirurg Bioquim & Inmunol, Malaga, Spain

Rubino, E:
 AOU Citt Salute & Sci Torino, Dept Neurosci & Mental Hlth, Turin, Italy

Rujescu, D:
 Med Univ Vienna, Dept Psychiat & Psychotherapy, Vienna, Austria

Saez, ME:
 Ctr Andaluz Estudios Bioinformat, CAEBI, Seville, Spain

Sakka, P:
 Athens Assoc Alzheimers Dis & Related Disorders, Athens, Greece

Saltvedt, I:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Hosp Trondheim, Dept Neurol & Clin Neurophysiol, Trondheim, Norway

 Trondheim Reg & Univ Hosp, Dept Geriatr, St Olavs Hosp, Trondheim, Norway

Sanchez-Arjona, MB:
 Hosp Univ Virgen del Rocio CSIC Univ Sevilla, Unidad Demencias, Inst Biomed Sevilla IBiS, Serv Neurol & Neurofisiol, Seville, Spain

Sanchez-Garcia, F:
 Hosp Univ Doctor Negrin, Dept Immunol, Las Palmas Gran Canaria, Las Palmas, Spain

Juan, PS:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Cantabria, Marques de Valdecilla Univ Hosp, Neurol Serv, Santander, Spain

 IDIVAL, Santander, Spain

Sanchez-Valle, R:
 Univ Barcelona, Neurol Dept, IDIBAPS, Hosp Clin, Barcelona, Spain

Sando, SB:
 IrCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Expt Neuropsychobiol Lab, Rome, Italy

 Univ Hosp Trondheim, Dept Neurol & Clin Neurophysiol, Trondheim, Norway

Sarnowski, C:
 Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA

Satizabal, CL:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

 Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

Scamosci, M:
 Univ Perugia, Inst Gerontol & Geriatr, Dept Med & Surg, Perugia, Italy

Scarmeas, N:
 Columbia Univ, Taub Inst Alzheimer S Dis & Aging Brain, Dept Neurol, New York, NY USA

 Natl & Kapodistrian Univ Athens, Aiginit Hosp, Med Sch, Dept Neurol 1, Athens, Greece

Scarpini, E:
 Osped Policlin, Fdn IRCCS Ca Granda, Milan, Italy

 Univ Milan, Milan, Italy

Scheltens, P:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

Scherbaum, N:
 Univ Duisburg Essen, LVR Hosp Essen, Med Fac, Dept Psychiat & Psychotherapy, Essen, Germany

Scherer, M:
 Univ Med Ctr Hamburg Eppendorf, Dept Primary Med Care, Hamburg, Germany

Schmid, M:
 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

 Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany

Schneider, A:
 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

Schott, JM:
 UCL Queen Sq Inst Neurol, Dementia Res Ctr, London, England

Selbaek, G:
 Univ Oslo, Inst Clin Med, Oslo, Norway

 Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway

Seripa, D:
 Vito Fazzi Hosp, Dept Hematol & Stem Cell Transplant, Lab Adv Hematol Diagnost, Lecce, Italy

Serrano, M:
 Hosp Clin San Carlos, Ctr Invest Biomed Red Diabet & Enfermed, CiBErDEM, Madrid, Spain

Sha, J:
 Univ Penn, Perelman Sch Med, Penn Neurodegenerat Genom Ctr, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

Shadrin, AA:
 Univ Oslo, NORMENT Ctr, Oslo, Norway

Skrobot, O:
 Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Bristol, Avon, England

Slifer, S:
 Univ Miami, John P Hussman Inst Human Genom, Miami, FL USA

Snijders, GJL:
 Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA

Soininen, H:
 Univ Eastern, Inst Clin Med, Neurol, Kuopio, Finland

Solfrizzi, V:
 Univ Bari A Moro, Bary, Italy

Solomon, A:
 Univ Eastern, Inst Clin Med, Neurol, Kuopio, Finland

 Karolinska Inst, Ctr Alzheimer Res Care Sci & Soc NVS, Div Clin Geriatr, Stockholm, Sweden

Song, Y:
 Case Western Reserve Univ, Dept Populat & Quantitat Hlth Sci, Cleveland, OH 44106 USA

Sorbi, S:
 Univ Florence, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy

 IRCCS Fdn Don Carlo Gnocchi, Florence, Italy

Sotolongo-Grau, O:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

Spalletta, G:
 IrCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Rome, Italy

Spottke, A:
 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

 Univ Bonn, Dept Neurol, Bonn, Germany

Squassina, A:
 Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy

Stordal, E:
 Namsos Hosp, Dept Psychiat, Namsos, Norway

Tartan, JP:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

Tarraga, L:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Tesi, N:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

 Vrije Univ Amsterdam, Dept Human Genet Amsterdam UMC, Sect Genom Neurodegenerat Dis & Aging, Amsterdam UMC, Amsterdam, Netherlands

Thalamuthu, A:
 Univ New South Wales, Fac Med, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

Thomas, T:
 Aristotle Univ Thessaloniki, Med Sch, Dept Neurol 1, Thessaloniki, Greece

 Alzheimer Hellas, Thessaloniki, Greece

Tosto, G:
 Columbia Univ, Taub Inst Alzheimer S Dis & Aging Brain, Dept Neurol, New York, NY USA

 Columbia Univ, Dept Neurol, New York, NY USA

Traykov, L:
 Med Univ Sofia, UH Alexandrovska, Clin Neurol, Sofia, Bulgaria

Tremolizzo, L:
 Univ Milano Bicocca, Sch Med & Surg, Milan, Italy

 San Gerardo Hosp, Neurol Unit, Monza, Italy

Tybjaeg-Hansen, A:
 Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

 Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

Uitterlinden, A:
 Erasmus MC, Dept Internal Med & Biostat, Rotterdam, Netherlands

Ullgren, A:
 Karolinska Inst, Ctr Alzheimer Res, Dept NVS, Div Neurogeriatr, Stockholm, Sweden

Ulstein, I:
 Oslo Univ Hosp, Dept Geriatr Med, Oslo, Norway

Valero, S:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Valladares, O:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Van Broeckhoven, C:
 VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium

 Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium

 VIB, VIB Ctr Mol Neurol, Neurodegenerat Brain Dis Grp, Antwerp, Belgium

Vance, J:
 Univ Miami, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL USA

Vardarajan, BN:
 Columbia Univ, Taub Inst Alzheimer S Dis & Aging Brain, Dept Neurol, New York, NY USA

van der Lugt, A:
 ErasmusMC, Dept Neurol, Rotterdam, Netherlands

Van Dongen, J:
 VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium

 Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium

 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium

van Rooij, J:
 Erasmus MC, Dept Neurol, Rotterdam, Netherlands

 ErasmusMC, Dept Neurol, Rotterdam, Netherlands

van Swieten, J:
 Erasmus MC, Dept Neurol, Rotterdam, Netherlands

Vandenberghe, R:
 Univ Leuven, Dept Neurosci, Lab Cognit Neurol, Leuven, Belgium

 Univ Hosp Leuven, Neurol Dept, Leuven, Belgium

Verhey, F:
 Maastricht Univ, Alzheimer Ctr Limburg, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

Vidal, JS:
 Univ Paris, EA 4468, Hop Broca, AP HP, Paris, France

Vogelgsang, J:
 Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

 Harvard Med Sch, Dept Psychiat, McLean Hosp, Belmont, MA USA

Vyhnalek, M:
 Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic

 Motol Univ Hosp, Prague, Czech Republic

 St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic

Wagner, M:
 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

Wallon, D:
 Normandie Univ, UNIROUEN,INSERM U1245,CHU Rouen, Normandy Ctr Genom & Personalized Med, Dept Neurol, F-76000 Rouen, France

 Normandie Univ, UNIROUEN,INSERM U1245,CHU Rouen, Normandy Ctr Genom & Personalized Med, CNR MAJ, F-76000 Rouen, France

Wang, LS:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Wang, RQ:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

Weinhold, L:
 Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany

Wiltfang, J:
 Univ Med Ctr Goettingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

 German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

 iBiMED, Med Sci Dept, Aveiro, Portugal

Windle, G:
 Bangor Univ, Sch Hlth Sci, Bangor, Gwynedd, Wales

Woods, B:
 Bangor Univ, Sch Hlth Sci, Bangor, Gwynedd, Wales

Yannakoulia, M:
 Harokopio Univ, Dept Nutr & Diatet, Athens, Greece

Zare, H:
 Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

Zhao, Y:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

Zhang, XL:
 Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA

Zhu, CC:
 Boston Univ, Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA

Zulaica, M:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Inst Biodonostia, Neurosci Area, San Sebastian, Spain

Farrer, LA:
 Univ Eastern Finland, Inst Biomed, Kuopio, Finland

 Boston Univ, Sch Med, Med Biomed Genet, Boston, MA 02118 USA

 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

Psaty, BM:
 Framingham Heart Dis Epidemiol Study, Framingham, MA USA

 Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA

 Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

Ghanbari, M:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

Raj, T:
 Icahn Sch Med Mt Sinai, Ronald M Loeb Ctr Alzheimers Dis, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Icahn Inst Data Sci & Genom Technol, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Estelle & Daniel Maggin Dept Neurol, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Nash Family Dept Neurosci, New York, NY 10029 USA

 Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA

Sachdev, P:
 Univ New South Wales, Fac Med, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

Mather, K:
 Univ New South Wales, Fac Med, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

Jessen, F:
 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

Ikram, MA:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

de Mendonca, A:
 Univ Lisbon, Fac Med, Lisbon, Portugal

Hort, J:
 NIA, Intramural Res Program, NIH, Bethesda, MD 20892 USA

 Charles Univ Prague, Fac Med 2, Dept Neurol, Prague, Czech Republic

 Motol Univ Hosp, Prague, Czech Republic

Tsolaki, M:
 Aristotle Univ Thessaloniki, Med Sch, Dept Neurol 1, Thessaloniki, Greece

 Alzheimer Hellas, Thessaloniki, Greece

Pericak-Vance, MA:
 Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland

Amouyel, P:
 Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France

Williams, J:
 Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

 Cardiff Univ, Sch Med, UKDRI Cardiff, Cardiff, Wales

Frikke-Schmidt, R:
 Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark

 Rigshosp, Dept Clin Biochem, Copenhagen, Denmark

Clarimon, J:
 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

 Univ Autanoma Barcelona, Dept Neurol, Hosp Santa Creu & St Pau, II B St Pau, Barcelona, Spain

Deleuze, JF:
 Univ Paris Saclay, CEA, Ctr Natl Rech Genom Humaine, Evry, France

Rossi, G:
 Ist Neurol Carlo Besta, Fdn IRCCS, Milan, Italy

Seshadri, S:
 Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

 Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

 Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

Andreassen, OA:
 Univ Oslo, NORMENT Ctr, Oslo, Norway

Ingelsson, M:
 Uppsala Univ, Dept Publ Hlth & Carins Sci Geriatr, Uppsala, Sweden

Hiltunen, M:
 Univ Fed Rio Grande do Norte, Brain Inst, Natal, RN, Brazil

Sleegers, K:
 VIB, VIB Ctr Mol Neurol, Complex Genet Alzheimers Dis Grp, Antwerp, Belgium

 Inst Born Bunge, Lab Neurogenet, Antwerp, Belgium

 Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium

Schellenberg, GD:
 Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA

van Duijn, CM:
 Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

 Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England

Sims, R:
 Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Sch Med, Div Psychol Med & Clin Neurosci, Cardiff, Wales

van der Flier, WM:
 Vrije Univ Amsterdam, Alzheimer Ctr Amsterdam, Dept Neurol, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands

Ruiz, A:
 Univ Int Catalunya, Res Ctr, Inst Catala Neurociencies Aplicades, Barcelona, Spain

 Univ Int Catalunya, Inst Catala Neurociencies Aplicades, Memory Clin Fundacio ACE, Barcelona, Spain

 Natl Inst Hlth Carlos III, Network Ctr Biomed Res Neurodegenerat Dis, CIBERNED, Madrid, Spain

Ramirez, A:
 Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany

 Univ Cologne, Med Fac, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany

 German Ctr Neurodegenerat Dis DZNE Bonn, Bonn, Germany

 Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA

 Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

Lambert, JC:
 Univ Lille, Facteurs Risque & Terminants Mol Malad Liees Viei, Inst Pasteur Lille, INSERM,U1167 RID AGE,CHU Lille, Lille, France
ISSN: 10614036
Editorial
NATURE PUBLISHING GROUP, 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA, Estados Unidos America
Tipo de documento: Article
Volumen: 54 Número: 4
Páginas: 412-436
WOS Id: 000778079600002
ID de PubMed: 36260740
imagen Green Accepted, Green Published, hybrid

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