Impairment measures versus inflammatory RODS in GBS and CIDP: a responsiveness comparison
Por:
Vanhoutte, EK, Draak, THP, Gorson, KC, van Nes, SI, Hoeijmakers, JGJ, Van der Pol, WL, Notermans, NC, Lewis, RA, Nobile-Orazio, E, Leger, JM, Van den Bergh, PYK, Lauria, G, Bril, V, Katzberg, H, Lunn, MPT, Pouget, J, van der Kooi, AJ, Hahn, AF, van Doorn, PA, Cornblath, DR, van den Berg, LH, Faber, CG, Merkies, ISJ, Illa I., Querol, L., PeriNomS Study Grp
Publicada:
1 sep 2015
Resumen:
This study aimed to define responder' through the concept of minimum clinically important differences using the individually obtained standard errors (MCID-SE) and a heuristic external criterion' responsiveness method in patients with Guillain-Barre syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). One hundred and fourteen newly diagnosed or relapsing patients (GBS: 55, CIDP: 59) were serially examined (1-year follow-up). The inflammatory Rasch-built overall disability scale (I-RODS), Rasch-transformed MRC sum score (RT-MRC), and Rasch-transformed modified-INCAT-sensory scale (RT-mISS) were assessed. Being-a-responder was defined as having a MCID-SE cut-off 1.96. Also, the correlations between patients' scores on each scale and the EuroQoL health-status thermometer' (external criterion) were determined (higher correlation indicated better responsiveness). In both diseases, the SEs showed a characteristic U'-shaped dynamic pattern across each scales' continuum. The number of patients showing a meaningful change were higher for the I-RODS>RT-MRC>RT-mISS and were in GBS higher than CIDP patients. The MCID-SE concept using Rasch-transformed data demonstrated an individual pattern of being-a-responder' in patients with immune-mediated neuropathies, and the findings were validated by the external criterion responsiveness method. The I-RODS showed greater responsiveness compared with the MRC and INCAT-sensory scales, and its use is therefore recommended in future trials in GBS and CIDP.
Filiaciones:
Vanhoutte, EK:
Univ Med Ctr Maastricht, Dept Clin Genet, Maastricht, Netherlands
Draak, THP:
Univ Med Ctr Maastricht, Dept Neurol, Maastricht, Netherlands
Gorson, KC:
Tufts Univ, Sch Med, St Elizabeths Med Ctr, Dept Neurol, Boston, MA 02111 USA
van Nes, SI:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Hoeijmakers, JGJ:
Univ Med Ctr Maastricht, Dept Neurol, Maastricht, Netherlands
Van der Pol, WL:
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurol, Utrecht, Netherlands
Notermans, NC:
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurol, Utrecht, Netherlands
Lewis, RA:
Cedars Sinai Med Ctr, Dept Neurol, Los Angeles, CA 90048 USA
Nobile-Orazio, E:
Univ Milan, Humanitas Clin Inst, Dept Neurol Sci, Milan, Italy
Leger, JM:
Hop La Pitie Salpetriere, Dept Neurol, Paris, France
Van den Bergh, PYK:
Catholic Univ Louvain, Dept Neurol, Leuven, Belgium
Lauria, G:
Natl Neurol Inst Carlo Besta, Neuromuscular Dis Unit, Milan, Italy
Bril, V:
Toronto Gen Hosp, Dept Neurol, Toronto, ON, Canada
Katzberg, H:
Toronto Gen Hosp, Dept Neurol, Toronto, ON, Canada
Lunn, MPT:
Natl Hosp Neurol & Neurosurg, Ctr Neuromuscular Dis, Dept Neurol, London WC1N 3BG, England
Pouget, J:
Hop Enfants La Timone, Dept Neurol, Ctr Reference Malad Neuromusculaires & SLA, Marseille, France
van der Kooi, AJ:
Univ Amsterdam, Acad Med Ctr, Dept Neurol, NL-1105 AZ Amsterdam, Netherlands
Hahn, AF:
London Hlth Sci Ctr, Dept Neurol, London, ON, Canada
van Doorn, PA:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Cornblath, DR:
Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA
van den Berg, LH:
Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Neurol, Utrecht, Netherlands
Faber, CG:
Univ Med Ctr Maastricht, Dept Neurol, Maastricht, Netherlands
Merkies, ISJ:
Univ Med Ctr Maastricht, Dept Neurol, Maastricht, Netherlands
Spaarne Hosp, Dept Neurol, Hoofddorp, Netherlands
Illa I.:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Querol, L.:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
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