Identification and characterization of near-fatal asthma phenotypes by cluster analysis
Por:
Serrano-Pariente, J, Rodrigo, G, Fiz, JA, Crespo, A, Plaza, V
Publicada:
1 sep 2015
Resumen:
BackgroundNear-fatal asthma (NFA) is a heterogeneous clinical entity and several profiles of patients have been described according to different clinical, pathophysiological and histological features. However, there are no previous studies that identify in a unbiased way - using statistical methods such as clusters analysis - different phenotypes of NFA. Therefore, the aim of the present study was to identify and to characterize phenotypes of near fatal asthma using a cluster analysis.
MethodsOver a period of 2years, 33 Spanish hospitals enrolled 179 asthmatics admitted for an episode of NFA. A cluster analysis using two-steps algorithm was performed from data of 84 of these cases.
ResultsThe analysis defined three clusters of patients with NFA: cluster 1, the largest, including older patients with clinical and therapeutic criteria of severe asthma; cluster 2, with an high proportion of respiratory arrest (68%), impaired conciousness level (82%) and mechanical ventilation (93%); and cluster 3, which included younger patients, characterized by an insufficient anti-inflammatory treatment and frequent sensitization to Alternaria alternata and soybean.
ConclusionsThese results identify specific asthma phenotypes involved in NFA, confirming in part previous findings observed in studies with a clinical approach. The identification of patients with a specific NFA phenotype could suggest interventions to prevent future severe asthma exacerbations.
Filiaciones:
Serrano-Pariente, J:
Hosp Comarcal dInca, Dept Pneumol, Balearic Isl, Spain
Rodrigo, G:
Hosp Cent Fuerzas Armadas, Emergency Dept, Montevideo, Uruguay
Fiz, JA:
Hosp Germans Trias i Pujol Badalona Barcelona, Inst Bioingn Catalunya IBEC, Dept Pneumol, Barcelona, Spain
Crespo, A:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau Barcelona, Dept Pneumol, IIB St Pau, E-08193 Barcelona, Spain
Plaza, V:
Univ Autonoma Barcelona, Hosp Santa Creu & St Pau Barcelona, Dept Pneumol, IIB St Pau, E-08193 Barcelona, Spain
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