The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia
Por:
Diaz-Beya, M, Brunet, S, Nomdedeu, J, Cordeiro, A, Tormo, M, Escoda, L, Ribera, JM, Arnan, M, Heras, I, Gallardo, D, Bargay, J, de Llano, MPQ, Salamero, O, Marti, JM, Sampol, A, Pedro, C, Hoyos, M, Pratcorona, M, Castellano, JJ, Nomdedeu, M, Risueno, RM, Sierra, J, Monzo, M, Navarro, A, Esteve, J
Publicada:
1 oct 2015
Resumen:
Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (>= 60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P = 0.0025), shorter leukemia-free survival (P = 0.026) and higher cumulative incidence of relapse (P = 0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P = 0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML.
Filiaciones:
Diaz-Beya, M:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Brunet, S:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Univ Autonoma Barcelona, IIB St Pau Res Inst, Hosp St Pau, Dept Hematol, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, IIB St Pau Res Inst, Hosp St Pau, Biol Hematol Lab, E-08193 Barcelona, Spain
Nomdedeu, J:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Univ Autonoma Barcelona, IIB St Pau Res Inst, Hosp St Pau, Dept Hematol, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, IIB St Pau Res Inst, Hosp St Pau, Biol Hematol Lab, E-08193 Barcelona, Spain
Cordeiro, A:
Univ Barcelona, Mol Oncol & Embryol Lab, Human Anat Unit, Sch Med, Barcelona, Spain
Tormo, M:
Hosp Clin, Dept Hematol, Valencia, Spain
Escoda, L:
Hosp Joan 23, Dept Hematol, Tarragona, Spain
Ribera, JM:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Hosp Badalona Germans Trias & Pujol, ICO, Hematol Dept, Badalona, Spain
Arnan, M:
Hosp Duran & Reynals, Dept Hematol, ICO, Barcelona, Spain
Heras, I:
Hosp Morales Meseguer, Dept Hematol, Murcia, Spain
Gallardo, D:
ICO Josep Trueta, Dept Hematol, Girona, Spain
Bargay, J:
Hosp Son Llatzer, Dept Hematol, Palma de Mallorca Hematol, Palma De Mallorca, Spain
de Llano, MPQ:
Hosp Virgen de la Victoria, Dept Hematol, Malaga, Spain
Salamero, O:
Hosp Valle De Hebron, Dept Hematol, Barcelona, Spain
Marti, JM:
Hosp Mutua de Terrassa, Dept Hematol, Barcelona, Spain
Sampol, A:
Hosp Son Llatzer, Dept Hematol, Palma Of Mallorca, Spain
Pedro, C:
Hosp Mar, Dept Hematol, Barcelona, Spain
Hoyos, M:
Univ Autonoma Barcelona, IIB St Pau Res Inst, Hosp St Pau, Dept Hematol, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, IIB St Pau Res Inst, Hosp St Pau, Biol Hematol Lab, E-08193 Barcelona, Spain
Pratcorona, M:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Castellano, JJ:
Univ Barcelona, Mol Oncol & Embryol Lab, Human Anat Unit, Sch Med, Barcelona, Spain
Nomdedeu, M:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Risueno, RM:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Sierra, J:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Univ Autonoma Barcelona, IIB St Pau Res Inst, Hosp St Pau, Dept Hematol, E-08193 Barcelona, Spain
Univ Autonoma Barcelona, IIB St Pau Res Inst, Hosp St Pau, Biol Hematol Lab, E-08193 Barcelona, Spain
Monzo, M:
Univ Barcelona, Mol Oncol & Embryol Lab, Human Anat Unit, Sch Med, Barcelona, Spain
Navarro, A:
Univ Barcelona, Mol Oncol & Embryol Lab, Human Anat Unit, Sch Med, Barcelona, Spain
Esteve, J:
Josep Carreras Leukaemia Res Inst, Barcelona, Spain
Univ Barcelona, Barcelona, Spain
Gold, Green Published
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