Cutaneous Allodynia in Migraine: A Narrative Review
Por:
Minguez-Olaondo, A, Quintas, S, Sanchez-Mateos, NM, Lopez-Bravo, A, Vila-Pueyo, M, Grozeva, V, Belvis, R, Santos-Lasaosa, S, Irimia, P
Publicada:
21 ene 2022
Resumen:
ObjectiveIn the present work, we conduct a narrative review of the most relevant literature on cutaneous allodynia (CA) in migraine. BackgroundCA is regarded as the perception of pain in response to non-noxious skin stimulation. The number of research studies relating to CA and migraine has increased strikingly over the last few decades. Therefore, the clinician treating migraine patients must recognize this common symptom and have up-to-date knowledge of its importance from the pathophysiological, diagnostic, prognostic and therapeutic point of view. MethodsWe performed a comprehensive narrative review to analyze existing literature regarding CA in migraine, with a special focus on epidemiology, pathophysiology, assessment methods, risk for chronification, diagnosis and management. PubMed and the Cochrane databases were used for the literature search. ResultsThe prevalence of CA in patients with migraine is approximately 60%. The mechanisms underlying CA in migraine are not completely clarified but include a sensitization phenomenon at different levels of the trigemino-talamo-cortical nociceptive pathway and dysfunction of brainstem and cortical areas that modulate thalamocortical inputs. The gold standard for the assessment of CA is quantitative sensory testing (QST), but the validated Allodynia 12-item questionnaire is preferred in clinical setting. The presence of CA is associated with an increased risk of migraine chronification and has therapeutic implications. ConclusionsCA is a marker of central sensitization in patients with migraine that has been associated with an increased risk of chronification and may influence therapeutic decisions.
Filiaciones:
Minguez-Olaondo, A:
Hosp Univ Donostia, Neurol Dept, San Sebastian, Spain
Policlin Guipuzcoa, Grp Quiron Salud Donostia, Athenea Neuroclin, San Sebastian, Spain
Biodonostia Hlth Inst, Neurosci Area, Donostia San Sebastian, Spain
Univ Deusto, Med Fac, Bilbao, Spain
Clin Univ Navarra, Pamplona, Spain
Quintas, S:
Hosp Univ Princesa, Madrid, Spain
Sanchez-Mateos, NM:
Hosp Santa Creu & Sant Pau, Neurol Dept, Headache & Neuralgia Unit, Barcelona, Spain
Lopez-Bravo, A:
Hosp Reina Sofia, Tudela, Spain
Inst Invest Sanitaria Aragon, Zaragoza, Spain
Vila-Pueyo, M:
Univ Autonoma Barcelona, Vall dHebron Res Inst, Dept Med, Headache & Neurol Pain Res Grp, Barcelona, Spain
Belvis, R:
Hosp Santa Creu & Sant Pau, Neurol Dept, Headache & Neuralgia Unit, Barcelona, Spain
Santos-Lasaosa, S:
Inst Invest Sanitaria Aragon, Zaragoza, Spain
Hosp Clin Univ Lozano Blesa, Zaragoza, Spain
Irimia, P:
Clin Univ Navarra, Pamplona, Spain
Green Published, gold
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