HIV infection and placental malaria reduce maternal transfer of multiple antimalarial antibodies in Mozambican women
Por:
Alonso, S, Vidal, M, Ruiz-Olalla, G, Gonzalez, R, Jairoce, C, Manaca, MN, Vazquez-Santiago, M, Balcells, R, Vala, A, Ruperez, M, Cistero, P, Fuente-Soro, L, Angov, E, Coppel, RL, Gamain, B, Cavanagh, D, Beeson, JG, Nhacolo, A, Sevene, E, Aponte, JJ, Macete, E, Aguilar, R, Mayor, A, Menendez, C, Dobano, C, Moncunill, G
Publicada:
1 abr 2021
Ahead of Print:
1 abr 2021
Resumen:
Objectives: Maternal Plasmodium falciparum-specific antibodies may contribute to protect infants against severe malaria. Our main objective was to evaluate the impact of maternal HIV infection and placental malaria on the cord blood levels and efficiency of placental transfer of IgG and IgG subclasses.
Methods: In a cohort of 341 delivering HIV-negative and HIV-positive mothers from southern Mozambique, we measured total IgG and IgG subclasses in maternal and cord blood pairs by quantitative suspension array technology against eight P. falciparum antigens: Duffy-binding like domains 3-4 of VAR2CSA from the erythrocyte membrane protein 1, erythrocyte-binding antigen 140, exported protein 1 (EXP1), merozoite surface proteins 1, 2 and 5, and reticulocyte-binding-homologue-4.2 (Rh4.2). We performed univariable and multivariable regression models to assess the association of maternal HIV infection, placental malaria, maternal variables and pregnancy outcomes on cord antibody levels and antibody transplacental transfer.
Results: Maternal antibody levels were the main determinants of cord antibody levels. HIV infection and placental malaria reduced the transfer and cord levels of IgG and IgG1, and this was antigen-dependent. Low birth weight was associated with an increase of IgG2 in cord against EXP1 and Rh4.2.
Conclusions: We found lower maternally transferred antibodies in HIV-exposed infants and those born from mothers with placental malaria, which may underlie increased susceptibility to malaria in these children. (C) 2021 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
Filiaciones:
Alonso, S:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Vidal, M:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ruiz-Olalla, G:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Gonzalez, R:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Jairoce, C:
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Manaca, MN:
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Vazquez-Santiago, M:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Balcells, R:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Vala, A:
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Ruperez, M:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
London Sch Hyg & Trop Med LSHTM, Keppel St, London WC1E 7HT, England
Cistero, P:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Fuente-Soro, L:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Angov, E:
Walter Reed Army Inst Res WRAIR, US Mil Malaria Vaccine Program, Silver Spring, MD USA
Coppel, RL:
Monash Univ, Infect & Immun Program, Monash Biomed Discovery Inst, Melbourne, Vic, Australia
Monash Univ, Dept Microbiol, Melbourne, Vic, Australia
Gamain, B:
Univ Sorbonne Paris Cite, Univ Paris Diderot, INSERM,Lab Excellence GR Ex, INTS,Unite Biol Integree Globule Rouge,UMR S1134, Paris, France
Cavanagh, D:
Univ Edinburgh, Sch Biol Sci, Inst Immunol & Infect Res, Kings Bldg,Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian, Scotland
Univ Edinburgh, Sch Biol Sci, Ctr Immun Infect & Evolut, Ashworth Labs, Kings Bldg,Charlotte Auerbach Rd, Edinburgh EH9 3FL, Midlothian, Scotland
Beeson, JG:
Burnet Inst, Melbourne, Vic 3004, Australia
Nhacolo, A:
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Sevene, E:
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Eduardo Mondlane Univ, Fac Med, Dept Physiol Sci, Clin Pharmacol, Maputo, Mozambique
Aponte, JJ:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Macete, E:
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Aguilar, R:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Mayor, A:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Menendez, C:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Dobano, C:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
Moncunill, G:
Univ Barcelona, Hosp Clin, ISGlobal, Carrer Rossello 153, E-08036 Barcelona, Catalonia, Spain
Ctr Invest Saude Manh CISM, Rua 12, Maputo 1929, Mozambique
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