Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology (vol 53, pg 1636, 2021)

Por: van Rheenen, W, van der Spek, RAA, Bakker, MK, van Vugt, JJFA, Hop, PJ, Zwamborn, RAJ, de Klein, N, Westra, HJ, Bakker, OB, Deelen, P, Shireby, G, Hannon, E, Moisse, M, Baird, D, Restuadi, R, Dolzhenko, E, Dekker, AM, Gawor, K, Westeneng, HJ, Tazelaar, GHP, van Eijk, KR, Kooyman, M, Byrne, RP, Doherty, M, Heverin, M, Al Khleifat, A, Iacoangeli, A, Shatunov, A, Ticozzi, N, Cooper-Knock, J, Smith, BN, Gromicho, M, Chandran, S, Pal, S, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Sendtner, M, Meyer, T, Basak, N, van der Kooi, AJ, Ratti, A, Fogh, I, Gellera, C, Lauria, G, Corti, S, Cereda, C, Sproviero, D, Soraru, G, Siciliano, G, Filosto, M, Padovani, A, Chio, A, Calvo, A, Moglia, C, Brunetti, M, Canosa, A, Grassano, M, Beghi, E, Pupillo, E, Logroscino, G, Nefussy, B, Osmanovic, A, Nordin, A, Lerner, Y, Zabari, M, Gotkine, M, Baloh, RH, Bell, S, Vourc'h, P, Corcia, P, Couratier, P, Millecamps, S, Meininger, V, Salachas, F, Pardina, JMS, Assialioui, A, Rojas-Garcia, R, Dion, PA, Ross, JP, Ludolph, AC, Weishaupt, JH, Brenner, D, Freischmidt, A, Bensimon, G, Brice, A, Durr, A, Payan, CAM, Saker-Delye, S, Wood, NW, Topp, S, Rademakers, R, Tittmann, L, Lieb, W, Franke, A, Ripke, S, Braun, A, Kraft, J, Whiteman, DC, Olsen, CM, Uitterlinden, AG, Hofman, A, Rietschel, M, Cichon, S, Nothen, MM, Amouyel, P, Comi, G, Riva, N, Lunetta, C, Gerardi, F, Cotelli, MS, Rinaldi, F, Chiveri, L, Guaita, MC, Perrone, P, Diamanti, L, Ferrarese, C, Tremolizzo, L, Delodovici, ML, Bono, G, Manera, U, Vasta, R, Bombaci, A, Casale, F, Fuda, G, Salamone, P, Iazzolino, B, Peotta, L, Cugnasco, P, De Marco, G, Torrieri, MC, Palumbo, F, Gallone, S, Barberis, M, Sbaiz, L, Gentile, S, Mauro, A, De Marchi, F, D'Alfonso, S, Bertolotto, A, Gionco, M, Leotta, D, Odddenino, E, Imperiale, D, Cavallo, R, Pignatta, P, De Mattei, M, Geda, C, Papurello, DM, Gusmaroli, G, Comi, C, Labate, C, Ruiz, L, Ferrandi, D, Rota, E, Aguggia, M, Di Vito, N, Meineri, P, Ghiglione, P, Launaro, N, Dotta, M, Di Sapio, A, Giardini, G, Tiloca, C, Peverelli, S, Taroni, F, Pensato, V, Castellotti, B, Comi, GP, Del Bo, R, Ceroni, M, Gagliardi, S, Corrado, L, Mazzini, L, Raggi, F, Simoncini, C, Lo Gerfo, A, Inghilleri, M, Ferlini, A, Simone, IL, Passarella, B, Guerra, V, Zoccolella, S, Nozzoli, C, Mundi, C, Leone, M, Zarrelli, M, Tamma, F, Valluzzi, F, Calabrese, G, Boero, G, Rini, A, Traynor, BJ, Singleton, AB, Neto, MM, Cauchi, RJ, Ophoff, RA, Wiedau-Pazos, M, Lomen-Hoerth, C, van Deerlin, VM, Grosskreutz, J, Roediger, A, Gaur, N, Jork, A, Barthel, T, Theele, E, Ilse, B, Stubendorff, B, Witte, OW, Steinbach, R, Hubner, CA, Graff, C, Brylev, L, Fominykh, V, Demeshonok, V, Ataulina, A, Rogelj, B, Koritnik, B, Zidar, J, Ravnik-Glavac, M, Glavac, D, Stevic, Z, Drory, V, Povedano, M, Blair, IP, Kiernan, MC, Benyamin, B, Henderson, RD, Furlong, S, Mathers, S, McCombe, PA, Needham, M, Ngo, ST, Nicholson, GA, Pamphlett, R, Rowe, DB, Steyn, FJ, Williams, KL, Mather, KA, Sachdev, PS, Henders, AK, Wallace, L, de Carvalho, M, Pinto, S, Petri, S, Weber, M, Rouleau, GA, Silani, V, Curtis, CJ, Breen, G, Glass, JD, Brown, RH, Landers, JE, Shaw, CE, Andersen, PM, Groen, EJN, van Es, MA, Pasterkamp, RJ, Fan, DS, Garton, FC, McRae, AF, Smith, GD, Gaunt, TR, Eberle, MA, Mill, J, McLaughlin, RL, Hardiman, O, Kenna, KP, Wray, NR, Tsai, EL, Runz, H, Franke, L, Al-Chalabi, A, Van Damme, P, van den Berg, LH, Veldink, JH, SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium

---

Publicada: 1 mar 2022 Ahead of Print: 1 ene 2022

---

---

Filiaciones:
van Rheenen, W:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

van der Spek, RAA:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Bakker, MK:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

van Vugt, JJFA:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Hop, PJ:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Zwamborn, RAJ:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

de Klein, N:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

Westra, HJ:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

Bakker, OB:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

Deelen, P:
 Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands

 Univ Utrecht, Univ Med Ctr Utrecht, Dept Genet, Utrecht, Netherlands

Shireby, G:
 Univ Exeter, Med Sch, Coll Med & Hlth, Exeter, England

Hannon, E:
 Univ Exeter, Med Sch, Coll Med & Hlth, Exeter, England

Moisse, M:
 Univ Leuven, Expt Neurol & Leuven Brain Inst, Dept Neurosci, LBI,KU Leuven, Leuven, Belgium

 Ctr Brain & Dis Res, Lab Neurobiol, VIB, Leuven, Belgium

 Univ Hosp Leuven, Dept Neurol, Leuven, Belgium

Baird, D:
 Biogen, Translat Biol, Boston, MA USA

 Univ Bristol, MRC Integrat Epidemiol Unit IEU, IEU, Populat Hlth Sci, Bristol, England

Restuadi, R:
 Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

Dolzhenko, E:
 Illumina, San Diego, CA USA

Dekker, AM:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Gawor, K:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Westeneng, HJ:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Tazelaar, GHP:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

van Eijk, KR:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Kooyman, M:
 Univ Utrecht, Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Neurol, Utrecht, Netherlands

Byrne, RP:
 Trinity Coll Dublin, Smurfit Inst Genet, Complex Trait Gen Lab, Dublin, Ireland

Doherty, M:
 Trinity Coll Dublin, Smurfit Inst Genet, Complex Trait Gen Lab, Dublin, Ireland

Heverin, M:
 Trinity Coll Dublin, Trinity BioMed Sci Inst, Acad Unit Neurol, Dublin, Ireland

Al Khleifat, A:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London, England

Iacoangeli, A:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London, England

 Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, London, England

 South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res Biomed Res Ctr, London, England

 South London & Maudsley NHS Fdn Trust, Dementia Unit, London, England

 Kings Coll London, London, England

Shatunov, A:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London, England

Ticozzi, N:
 Ist Auxol Italiano IRCCS, Dept Neurol, Stroke Unit, Lab Neurosci, Milan, Italy

 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy

Cooper-Knock, J:
 Univ Sheffield, Sheffield Inst Translat Neurosci SITraN, Sheffield, England

Smith, BN:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London, England

Gromicho, M:
 Univ Lisbon, Fac Med, Inst Fisiol, Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal

Chandran, S:
 Euan MacDonald Ctr Motor Neurone Dis Res, Edinburgh, Scotland

 Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Scotland

Pal, S:
 Euan MacDonald Ctr Motor Neurone Dis Res, Edinburgh, Scotland

 Univ Edinburgh, UK Dementia Res Inst, Edinburgh, Scotland

 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

Morrison, KE:
 Queens Univ Belfast, Sch Med, Dent & BioMed Sci, Belfast, North Ireland

Shaw, PJ:
 Univ Sheffield, Sheffield Inst Translat Neurosci SITraN, Sheffield, England

Hardy, J:
 UCL, Inst Neurol, Dept Mol Neurosci, London, England

Orrell, RW:
 UCL, UCL Queen Sq Inst Neurol, Dept Clin & Movement Neurosci, London, England

Sendtner, M:
 Univ Hosp Wurzburg, Inst Clin Neurobiol, Wurzburg, Germany

Meyer, T:
 Charite, Humboldt Univ, Berlin, Germany

Basak, N:
 Bogazici Univ, Neurodegenerat Res Lab, Istanbul, Turkey

van der Kooi, AJ:
 Acad Med Ctr, Dept Neurol, Amsterdam, Netherlands

Ratti, A:
 Ist Auxol Italiano IRCCS, Dept Neurol, Stroke Unit, Lab Neurosci, Milan, Italy

 Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy

Fogh, I:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London, England

Gellera, C:
 Fdn IRCCS Ist Neurol Carlo Besta, Unit Med Genet & Neurogenet, Milan, Italy

Lauria, G:
 Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy

 Fdn IRCCS Ist Neurol Carlo Besta, Motor Neuron Dis Ctr, Neurol Unit 3, Milan, Italy

Corti, S:
 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy

 IRCCS Fdn Ca Granda Osped Maggiore Policlin, Neurol Unit, Milan, Italy

Cereda, C:
 IRCCS Mondino Fdn, Genom & Postgenom Ctr, Pavia, Italy

Sproviero, D:
 IRCCS Mondino Fdn, Genom & Postgenom Ctr, Pavia, Italy

Soraru, G:
 Univ Padua, Dept Neurosci, Padua, Italy

Siciliano, G:
 Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

Filosto, M:
 Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy

Padovani, A:
 Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy

Chio, A:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Citta Salute Della Sci, Neurol 1, Azienda Osped, Turin, Italy

Calvo, A:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Citta Salute Della Sci, Neurol 1, Azienda Osped, Turin, Italy

Moglia, C:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Citta Salute Della Sci, Neurol 1, Azienda Osped, Turin, Italy

Brunetti, M:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

Canosa, A:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Citta Salute Della Sci, Neurol 1, Azienda Osped, Turin, Italy

 Univ Citta Salute Sci, Neurol Unit 1U, Azienda Osped, Turin, Italy

Grassano, M:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

Beghi, E:
 Ist Ric Farmacol Mario Negri IRCCS, Dept Neurosci, Lab Neurol Dis, Milan, Italy

Pupillo, E:
 Ist Ric Farmacol Mario Negri IRCCS, Dept Neurosci, Lab Neurol Dis, Milan, Italy

Logroscino, G:
 Univ Bari Pia Fdn Card G Panico Hosp, Dept Clin Res Neurol, Bari, Italy

Nefussy, B:
 Tel Aviv Sourasky Med Ctr, Dept Neurol, Neuromuscular Dis Unit, Tel Aviv, Israel

Osmanovic, A:
 Hannover Med Sch, Dept Neurol, Hannover, Germany

 Univ Hosp Essen, Essener Zentrum Seltene Erkrankungen EZSE, Essen, Germany

Nordin, A:
 Umea Univ, Dept Clin Sci, Neurosci, Umea, Sweden

Lerner, Y:
 Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

 Agnes Ginges Ctr Human Neurogenet, Hadassah Med Ctr, Dept Neurol, Jerusalem, Israel

Zabari, M:
 Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

 Agnes Ginges Ctr Human Neurogenet, Hadassah Med Ctr, Dept Neurol, Jerusalem, Israel

Gotkine, M:
 Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

 Agnes Ginges Ctr Human Neurogenet, Hadassah Med Ctr, Dept Neurol, Jerusalem, Israel

Baloh, RH:
 Cedars Sinai Med Ctr, Ctr Neural Sci & Med, Los Angeles, CA USA

 Sinai Med Ctr, Dept Neurol, Neuromuscular Div, Los Angeles, CA USA

Bell, S:
 Cedars Sinai Med Ctr, Ctr Neural Sci & Med, Los Angeles, CA USA

 Sinai Med Ctr, Dept Neurol, Neuromuscular Div, Los Angeles, CA USA

Vourc'h, P:
 CHU Tours, Serv BioChim Biol Mol, Tours, France

 Univ Tours, UMR 1253, Inserm, Tours, France

Corcia, P:
 Univ Tours, UMR 1253, Inserm, Tours, France

 Ctr Reference SLA, CHU Tours, Tours, France

Couratier, P:
 CHRU Limoges, Ctr Reference SLA, Limoges, France

 Univ Limoges, UMR 1094, Inserm, Limoges, France

Millecamps, S:
 Sorbonne Univ, Inst Cerveau, Hop Pitie, ICM,Inserm,CNRS, Paris, France

Meininger, V:
 Hop Peupliers, Ramsay Gen Sante, Paris, France

Salachas, F:
 Sorbonne Univ, Inst Cerveau, Hop Pitie, ICM,Inserm,CNRS, Paris, France

 Ctr Reference SLA Ile France, Dept Neurol, Hop Pitie, AP HP, Paris, France

Pardina, JMS:
 Hosp San Rafael, ALS Unit, Madrid, Spain

Assialioui, A:
 Bellvitge Univ Hosp, Serv Neurol, Funct Unit Amyotroph Lateral Sclerosis, UFELA, Barcelona, Spain

Rojas-Garcia, R:
 Univ Autonoma Barcelona, Hosp Santa Creu Sant Pau Barcelona, Neurol Dept, MND Clin, Barcelona, Spain

Dion, PA:
 McGill Univ, Montreal Neurol Inst Hosp, Montreal, PQ, Canada

 McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada

Ross, JP:
 McGill Univ, Montreal Neurol Inst Hosp, Montreal, PQ, Canada

 McGill Univ, Dept Human Genet, Montreal, PQ, Canada

Ludolph, AC:
 Ulm Univ, Dept Neurol, Ulm, Germany

Weishaupt, JH:
 Univ Med Mannheim, Heidelberg Univ, Div Neurodegenerat, Med Fac Mannheim,Dept Neurol, Mannheim, Germany

Brenner, D:
 Univ Med Mannheim, Heidelberg Univ, Div Neurodegenerat, Med Fac Mannheim,Dept Neurol, Mannheim, Germany

Freischmidt, A:
 Ulm Univ, Dept Neurol, Ulm, Germany

 German Ctr Neurodegenerat Dis, DZNE, Ulm, Germany

Bensimon, G:
 Dept Pharmacol Clin, Hop Pitie, UPMC Pharmacol, AP HP, Paris, France

 Pharmacol Sorbonne Univ, Paris, France

 Paris Brain Inst ICM, Inst Cerveau, Paris, France

 CHU Nimes, Lab Biostat, BESPIM, Nimes, France

Brice, A:
 Sorbonne Univ, Paris Brain Inst, Hop Pitie Salpetriere, APHP,INSERM,CNRS, Paris, France

Durr, A:
 Sorbonne Univ, Paris Brain Inst, Hop Pitie Salpetriere, APHP,INSERM,CNRS, Paris, France

Payan, CAM:
 Dept Pharmacol Clin, Hop Pitie, UPMC Pharmacol, AP HP, Paris, France

Saker-Delye, S:
 Genethon, CNRS UMR, Evry, France

Wood, NW:
 UCL Inst Neurol, Dept Clin & Movement Neurosci, London, England

Topp, S:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London, England

Rademakers, R:
 Mayo Clin Coll Med, Dept Neurosci, Jacksonville, FL USA

Tittmann, L:
 Christian Albrechts Univ Kiel, Popgen Biobank, Kiel, Germany

 Christian Albrechts Univ Kiel, Inst Epidmiol, Kiel, Germany

Lieb, W:
 Christian Albrechts Univ Kiel, Popgen Biobank, Kiel, Germany

 Christian Albrechts Univ Kiel, Inst Epidmiol, Kiel, Germany

Franke, A:
 Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

Ripke, S:
 Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA USA

 Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA USA

 Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

Braun, A:
 Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

Kraft, J:
 Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

Whiteman, DC:
 QIMR Berghofer Med Res Inst, Canc Control Grp, Herston, Qld, Australia

Olsen, CM:
 QIMR Berghofer Med Res Inst, Canc Control Grp, Herston, Qld, Australia

Uitterlinden, AG:
 Erasmus MC, Dept Internal Med, Genet Lab, Rotterdam, Netherlands

 Erasmus MC, Dept Epidmiol, Rotterdam, Netherlands

Hofman, A:
 Erasmus MC, Dept Epidmiol, Rotterdam, Netherlands

Rietschel, M:
 Heidelberg Univ, Med Fac Mannheim, Heidelberg, Germany

 Cent Inst Mental Hlth, Mannheim, Germany

Cichon, S:
 Univ Bonn, Inst Human Genet, Bonn, Germany

 Life & Brain Ctr, Dept Gen, Bonn, Germany

 Univ Hosp Basel, Univ Basel, Dept BioMed, Div Med Genet, Basel, Switzerland

 Inst Neurosci & Med INM, Res Ctr Juelich, Julich, Germany

Nothen, MM:
 Univ Bonn, Inst Human Genet, Bonn, Germany

 Life & Brain Ctr, Dept Gen, Bonn, Germany

Amouyel, P:
 Univ Lille, Ctr Hosp Univ Lille, Inst Pasteur Lille,INSERM UMR1167-RID, AGE LabEx DISTALZ-Risk Factors & Mol Determinants, Lille, France

Lunetta, C:
 Casa Cura Policlin, Milan, Italy

Gerardi, F:
 IRCCS San Raffaele Hosp, Milan, Italy

Cotelli, MS:
 Civil Hosp Brescia, Brescia, Italy

Rinaldi, F:
 Osped Niguarda Ca Granda, Serena Onlus Fdn, NEMO Clin Ctr, Milan, Italy

Chiveri, L:
 Neurol Unit, ASST Valcamon, Esine, Brescia, Italy

Guaita, MC:
 Civil Hosp Brescia, Brescia, Italy

Perrone, P:
 Osped Valduce, Como, Italy

Diamanti, L:
 Osped Civile Legnano, Legnano, Italy

Ferrarese, C:
 IRCCS Ist Neurol Nazl C Mondino, Pavia, Italy

Tremolizzo, L:
 IRCCS Ist Neurol Nazl C Mondino, Pavia, Italy

Delodovici, ML:
 San Gerardo Monza & Univ Milano, Bicocca, Milan, Italy

 Ospedale Circolo Fdn Macchi Varese, Varese, Italy

Bono, G:
 San Gerardo Monza & Univ Milano, Bicocca, Milan, Italy

 Ospedale Circolo Fdn Macchi Varese, Varese, Italy

Manera, U:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Citta Salute Della Sci, Neurol 1, Azienda Osped, Turin, Italy

Vasta, R:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

Fuda, G:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Citta Salute Della Sci, Neurol 1, Azienda Osped, Turin, Italy

Salamone, P:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

Iazzolino, B:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

Cugnasco, P:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

Barberis, M:
 Univ Citta Salute Sci, Dept Med Genet, Azienda Osped, Turin, Italy

Sbaiz, L:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Citta Salute Sci, Dept Med Genet, Azienda Osped, Turin, Italy

Gentile, S:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Citta Salute Sci, Neurol 3, Azienda Osped, Turin, Italy

Mauro, A:
 Univ Citta Salute Della Sci, Neurol 1, Azienda Osped, Turin, Italy

 IRCCS, Ist Auxol Italiano, Oggebbio, Italy

De Marchi, F:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Univ Maggiore Carit, Azienda Osped, Novara, Italy

D'Alfonso, S:
 Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy

 Univ Maggiore Carit, Azienda Osped, Novara, Italy

 Amedeo Avogadro Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy

Bertolotto, A:
 Univ San Luigi, Multiple Sclerosis Ctr, Dept Neurol, Azienda Osped, Orbassano, Italy

Gionco, M:
 Azienda Osped Ordine Mauriziano Torino, Dept Neurol, Turin, Italy

Leotta, D:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Osped Martini, Dept Neurol, ASL Citta Torino, Turin, Italy

Odddenino, E:
 Osped Martini, Dept Neurol, ASL Citta Torino, Turin, Italy

Imperiale, D:
 Osped Maria Vittoria, Dept Neurol, ASL Citta Torino, Turin, Italy

Cavallo, R:
 Osped San Giovanni Bosco, Dept Neurol, ASL Citta Torino, Turin, Italy

Pignatta, P:
 Osped Humanitas Gradenigo, Turin, Italy

De Mattei, M:
 Osped Santa Croce Moncalieri, Dept Neurol, ASL Torino 5, Moncaliari, Italy

Geda, C:
 Osped Civile Ivrea, Dept Neurol, ASL Torino 4, Ivrea, Italy

Papurello, DM:
 Dept Neurol, Presidio Osped Cirie, ASL Torino 4, Cirie, Italy

Gusmaroli, G:
 Osped Degli Infermi Biella, Dept Neurol, ASL Biella, Ponderano, Italy

Comi, C:
 IRCCS San Raffaele Hosp, Milan, Italy

 V Salute San Raffaele Univ, Milan, Italy

 Osped St Andrea Vercelli, Dept Neurol, ASL Vercelli, Vercelli, Italy

 Amedeo Avogadro Univ Piemonte Orientale, Dept Clin & Expt Med, Novara, Italy

Labate, C:
 Osped Civile Edoardo Agnelli Pinerolo, Dept Neurol, ALS Torino 2, Pinerolo, Italy

Ruiz, L:
 Dept Neurol, Azienda Osped Santi Antonio Biagio Alesss, Alessandria, Italy

Ferrandi, D:
 Osped Santo Spirito Casale Monferrato, Dept Neurol, ASL Alessandria, Casale Monferrato, Italy

Rota, E:
 Osped San Giacomo Novi Ligure, Dept Neurol, ASL Alesssandria, Novi Ligure, Italy

Aguggia, M:
 Osped Cardinal Massia Asti, Dept Neurol, ASL Asti, Asti, Italy

Di Vito, N:
 Osped Cardinal Massia Asti, Dept Neurol, ASL Asti, Asti, Italy

Meineri, P:
 Azienda Osped Santa Croce Carle Cuneo, Dept Neurol, Cuneo, Italy

Ghiglione, P:
 Osped Maggiore Santissima Annuziata Savigliano, Dept Neurol, ASL Cuneo 1, Savigliano, Italy

Launaro, N:
 Osped Maggiore Santissima Annuziata Savigliano, Dept Anesthesiol, ASL Cuneo 1, Savigliano, Italy

Dotta, M:
 Osped Michele Pietro Ferrero Verduno, Dept Neurol, ASL Cuneo 2, Verduno, Italy

Di Sapio, A:
 Osped Regina Montis Regalis Mondovi, Dept Neurol, ASL Cuneo 1, Aosta, Italy

Giardini, G:
 Osped Regionale Umberto Parini Aosta, Dept Neurol, Aosta, Italy

Taroni, F:
 Fdn IRCCS Ist Neurol Carlo Besta, Unit Med Genet & Neurogenet, Milan, Italy

Pensato, V:
 Fdn IRCCS Ist Neurol Carlo Besta, Unit Med Genet & Neurogenet, Milan, Italy

Castellotti, B:
 Fdn IRCCS Ist Neurol Carlo Besta, Unit Med Genet & Neurogenet, Milan, Italy

Del Bo, R:
 Ist Auxol Italiano IRCCS, Dept Neurol, Stroke Unit, Lab Neurosci, Milan, Italy

 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy

 IRCCS Fdn Ca Granda Osped Maggiore Policlin, Neurol Unit, Milan, Italy

Ceroni, M:
 Osped Civile Legnano, Legnano, Italy

 IRCCS Mondino Fdn, Unit Gen Neurol, Pavia, Italy

 Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

Gagliardi, S:
 IRCCS Mondino Fdn, Genom & Postgenom Ctr, Pavia, Italy

Corrado, L:
 Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy

 Univ Citta Salute Della Sci, Neurol 1, Azienda Osped, Turin, Italy

 Univ Maggiore Carit, Azienda Osped, Novara, Italy

 Amedeo Avogadro Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy

Mazzini, L:
 Univ Torino, ALS Ctr, Rita Levi Montalcini Dept Neurosci, Turin, Italy

 Amedeo Avogadro Univ Piemonte Orientale, Dept Neurol, Novara, Italy

 Univ Maggiore Carit, Azienda Osped, Novara, Italy

 Univ Maggiore Car, ALS Ctr, Dept Neurol, Azienda Osped, Novara, Italy

Raggi, F:
 Ist Auxol Italiano IRCCS, Dept Neurol, Stroke Unit, Lab Neurosci, Milan, Italy

 Univ Padua, Dept Neurosci, Padua, Italy

Simoncini, C:
 Ist Auxol Italiano IRCCS, Dept Neurol, Stroke Unit, Lab Neurosci, Milan, Italy

 Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

Lo Gerfo, A:
 Univ Pisa, Dept Clin & Expt Med, Pisa, Italy

 Osped Niguarda Ca Granda, Serena Onlus Fdn, NEMO Clin Ctr, Milan, Italy

Inghilleri, M:
 Sapienza Univ, Rare Neuromuscular Dis Ctr, Dept Human Neurosci, Rome, Italy

Ferlini, A:
 Univ Ferrara, Dept Med Sci, Unit Med Genet, Ferrara, Italy

Simone, IL:
 Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy

Passarella, B:
 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy

 IRCCS Fdn Ca Granda Osped Maggiore Policlin, Neurol Unit, Milan, Italy

 Antonio Perrinos Hosp, Neurol Dept, Brindisi, Italy

Guerra, V:
 Bellis Res Hosp, Natl Inst Digest Dis, IRCCS S, Castellana Grotte, Italy

Zoccolella, S:
 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy

 IRCCS Fdn Ca Granda Osped Maggiore Policlin, Neurol Unit, Milan, Italy

 San Paolo Hosp, ASL Bari, Bari, Italy

Nozzoli, C:
 Antonio Perrinos Hosp, Neurol Dept, Brindisi, Italy

Mundi, C:
 United Hosp Foggia, Dept Neurosci, Foggia, Italy

Leone, M:
 Fdn IRCCS Casa Sollievo Sofferenza, Dept Emergency & Crit Care, Unit Neurol, San Giovanni Rotondo, Italy

Zarrelli, M:
 Fdn IRCCS Casa Sollievo Sofferenza, Dept Emergency & Crit Care, Unit Neurol, San Giovanni Rotondo, Italy

Tamma, F:
 Miulli Hosp, Neurol Unit, Acquaviva Delle Fonti, Italy

Valluzzi, F:
 S Giacomo Hosp, Unit Neurol, Bari, Italy

Calabrese, G:
 V Fazzi Hosp, Dept Neurol, ASL Local Hlth Author, Lecce, Italy

Boero, G:
 SS Annunziata Hosp, Dept Neurol, ASL Local Hlth Author, Taranto, Italy

Rini, A:
 Antonio Perrinos Hosp, Neurol Dept, Brindisi, Italy

Traynor, BJ:
 Natl Inst Aging, Porter Neurosci Res Ctr, Neuromuscular Dis Res Sect, Lab Neurogenet,NIH, Bethesda, MD USA

 Johns Hopkins Univ, Dept Neurol, Baltimore, MD USA

Singleton, AB:
 Natl Inst Aging, Porter Neurosci Res Ctr, Lab Neurogenet, Mol Genet Sect,NIH, Bethesda, MD USA

Neto, MM:
 Univ Sao Paulo, Sao Paulo, Brazil

Cauchi, RJ:
 Univ Malta, Fac Med, Biochem, Ctr Mol Med,Dept Physiol,Biobanking,Surg, Msida, Msida, Malta

Ophoff, RA:
 Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, Utrecht, Netherlands

 Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA USA

 Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Ctr Neurobehav Genet, Los Angeles, CA USA

Wiedau-Pazos, M:
 Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Los Angeles, CA USA

Lomen-Hoerth, C:
 Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

van Deerlin, VM:
 Univ Penn, Ctr Neurodegenerat Dis Res, Perelman Sch Med, Philadelphia, PA USA

Grosskreutz, J:
 Univ Hosp Schleswig, Univ Luebeck, Dept Neurol, Precis Neurol Unit, Lubeck, Germany

Hubner, CA:
 Jena Univ Hosp, Inst Human Genet, Jena, Germany

Graff, C:
 Karolinska Univ Hosp Huddinge, Dept Geriatr Med, Stockholm, Sweden

Brylev, L:
 Bujanov Moscow Clin Hosp, Dept Neurol, Moscow, Russia

 Moscow Res & Clin Ctr Neuropsychiat Healthcare, Moscow, Russia

 Russian Acad Sci, Inst Higher Nervous Act, Dept Funct Biochem Nervous Syst, Neurophysiol, Moscow, Russia

Fominykh, V:
 Bujanov Moscow Clin Hosp, Dept Neurol, Moscow, Russia

 Russian Acad Sci, Inst Higher Nervous Act, Dept Funct Biochem Nervous Syst, Neurophysiol, Moscow, Russia

Demeshonok, V:
 ALS Care Ctr, Med Clin St, GAOORDI, St Petersburg, Russia

Ataulina, A:
 Bujanov Moscow Clin Hosp, Dept Neurol, Moscow, Russia

Rogelj, B:
 Jozef Stefan Inst, Dept Biotechnol, Ljubljana, Slovenia

 BioMed Res Inst BRIS, Ljubljana, Slovenia

 Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana, Slovenia

Koritnik, B:
 Univ Med Ctr Ljubljana, Inst Clin Neurophysiol, Ljubljana ALS Ctr, Ljubljana, Slovenia

Zidar, J:
 Univ Med Ctr Ljubljana, Inst Clin Neurophysiol, Ljubljana ALS Ctr, Ljubljana, Slovenia

Ravnik-Glavac, M:
 Univ Ljubljana, Inst Biochem & Mol Genet, Fac Med, Ljubljana, Slovenia

Glavac, D:
 Univ Ljubljana, Inst Pathol, Fac Med, Dept Mol Genet, Ljubljana, Slovenia

Stevic, Z:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Univ Belgrade, Clin Ctr Serbia, Sch Med, Clin Neurol, Belgrade, Belgrade, Serbia

Drory, V:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

Povedano, M:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

Blair, IP:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Macquarie Univ, Fac Med, Ctr Motor Neuron Dis Res Hlth & Human Sci, Sydney, NSW, Australia

Kiernan, MC:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia

Benyamin, B:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Univ South Australia, Australian Ctr Precis Hlth & Allied Hlth & Hum, Adelaide, SA, Australia

Henderson, RD:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Univ Queensland, Australian Inst BioEngn & Nanotechnol, Centre Clin Res, Brisbane, Qld, Australia

 Royal Brisbane & Womens Hosp, Dept Neurol, Brisbane, Qld, Australia

Furlong, S:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Macquarie Univ, Fac Med, Ctr Motor Neuron Dis Res Hlth & Human Sci, Sydney, NSW, Australia

Mathers, S:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Calvary Hlth Care Bethlehem, Parkdale, Vic, Australia

McCombe, PA:
 Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany

 Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

Needham, M:
 Fiona Stanley Hosp, Perth, WA, Australia

 Notre Dame Univ, Fremantle, WA, Australia

 Murdoch Univ, Hlth Futures Inst, Ctr Mol Med & Innovat Therapeut, Perth, WA, Australia

Ngo, ST:
 Univ Queensland, Australian Inst BioEngn & Nanotechnol, Centre Clin Res, Brisbane, Qld, Australia

 Royal Brisbane & Womens Hosp, Dept Neurol, Brisbane, Qld, Australia

Nicholson, GA:
 Macquarie Univ, Fac Med, Ctr Motor Neuron Dis Res Hlth & Human Sci, Sydney, NSW, Australia

 ANZAC Res Inst, Northcott Neurosci Lab, Concord, NSW, Australia

 Concord Repatriat Gen Hosp, Mol Med Lab, Concord, NSW, Australia

Pamphlett, R:
 Univ Sydney, Mind Ctr, Dept Neuropathol, Discipline Pathol, Sydney, NSW, Australia

Rowe, DB:
 Macquarie Univ, Fac Med, Ctr Motor Neuron Dis Res Hlth & Human Sci, Sydney, NSW, Australia

Steyn, FJ:
 Univ Queensland, Fac Med, Sch BioMed Sci, Brisbane, Qld, Australia

Williams, KL:
 Macquarie Univ, Fac Med, Ctr Motor Neuron Dis Res Hlth & Human Sci, Sydney, NSW, Australia

Mather, KA:
 Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

 Neurosci Res Australia Inst, Randwick, NSW, Australia

Sachdev, PS:
 Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia

 UNSW, Prince Wales Hosp, Neuropsychiat Inst, Randwick, NSW, Australia

Petri, S:
 Bellvitge Univ Hosp, Serv Neurol, Funct Unit Amyotroph Lateral Sclerosis, UFELA, Barcelona, Spain

Weber, M:
 ALS Clin, Neuromuscular Dis Unit, Kantonsspital St, St Gallen, Switzerland

Silani, V:
 Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

Curtis, CJ:
 Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, Psychology & Neurosci,IoPPN, London, England

 South London & Maudsley NHS Fdn Trust, Inst Psychiat, NIHR BioResource Ctr Maudsley, NIHR Maudsley BioMed Res Ctr,BRC,King's Coll Lond, London, England

Breen, G:
 Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, Psychology & Neurosci,IoPPN, London, England

 South London & Maudsley NHS Fdn Trust, Inst Psychiat, NIHR BioResource Ctr Maudsley, NIHR Maudsley BioMed Res Ctr,BRC,King's Coll Lond, London, England

Glass, JD:
 Emory Univ, Dept Neurol, Sch Med, Atlanta, GA USA

Brown, RH:
 Univ Massachusetts Med Sch, Dept Neurol, Worcester, MA USA

Landers, JE:
 Univ Massachusetts Med Sch, Dept Neurol, Worcester, MA USA

Pasterkamp, RJ:
 Univ Med Ctr Utrecht, Utrecht Univ, UMC Utrecht Brain Ctr, Dept Translat Neurosci, Utrecht, Netherlands

Fan, DS:
 Peking Univ Third Hosp, Dept Neurol, Beijing, Peoples R China

Smith, GD:
 Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

 Univ Bristol Sch Med, Populat Hlth Sci, Bristol, England

Gaunt, TR:
 Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia

 Univ Bristol Sch Med, Populat Hlth Sci, Bristol, England

Eberle, MA:
 Univ Lisbon, Fac Med, Inst Fisiol, Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal

Mill, J:
 Univ Lisbon, Fac Med, Inst Fisiol, Inst Med Mol Joao Lobo Antunes, Lisbon, Portugal

Kenna, KP:
 Univ Med Ctr Utrecht, Utrecht Univ, UMC Utrecht Brain Ctr, Dept Translat Neurosci, Utrecht, Netherlands

Wray, NR:
 Ist Auxol Italiano IRCCS, Dept Neurol, Stroke Unit, Lab Neurosci, Milan, Italy

 Univ Milan, Dino Ferrari Ctr, Dept Pathophysiol & Transplantat, Milan, Italy

Al-Chalabi, A:
 Kings Coll Hosp London, London, England

van den Berg, LH:
 Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, Inst Psychiat Psychol & Neurosci, London, England

Veldink, JH:
 SS Annunziata Hosp, Dept Neurol, ASL Local Hlth Author, Taranto, Italy