The impact of cognitive reserve, cognition and clinical symptoms on psychosocial functioning in first-episode psychoses
Por:
Amoretti, S, Rosa, AR, Mezquida, G, Cabrera, B, Ribeiro, M, Molina, M, Bioque, M, Lobo, A, Gonzalez-Pinto, A, Fraguas, D, Corripio, I, Vieta, E, de la Serna, E, Morro, L, Garriga, M, Torrent, C, Cuesta, MJ, Bernardo, M, PEPs Grp
Publicada:
1 feb 2022
Resumen:
Background Functional impairment is a defining feature of psychotic disorders. A range of factors has been shown to influence functioning, including negative symptoms, cognitive performance and cognitive reserve (CR). However, it is not clear how these variables may affect functioning in first-episode psychosis (FEP) patients. This 2-year follow-up study aimed to explore the possible mediating effects of CR on the relationship between cognitive performance or specific clinical symptoms and functional outcome. Methods A prospective study of non-affective FEP patients was performed (211 at baseline and 139 at follow-up). CR was entered in a path analysis model as potential mediators between cognitive domains or clinical symptoms and functioning. Results At baseline, the relationship between clinical variables or cognitive performance and functioning was not mediated by CR. At follow-up, the effect of attention (p = 0.003) and negative symptoms (p = 0.012) assessed at baseline on functioning was partially mediated by CR (p = 0.032 and 0.016), whereas the relationship between verbal memory (p = 0.057) and functioning was mediated by CR (p = 0.014). Verbal memory and positive and total subscales of PANSS assessed at follow-up were partially mediated by CR and the effect of working memory on functioning was totally mediated by CR. Conclusions Our results showed the influence of CR in mediating the relationship between cognitive domains or clinical symptoms and functioning in FEP. In particular, CR partially mediated the relationship between some cognitive domains or clinical symptoms and functioning at follow-up. Therefore, CR could improve our understanding of the long-term functioning of patients with a non-affective FEP.
Filiaciones:
Amoretti, S:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Rosa, AR:
Hosp Clin Porto Alegre, Lab Mol Psychiat, Porto Alegre, RS, Brazil
Univ Fed Rio Grande Sul UFRGS, Postgrad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil
Univ Fed Rio Grande Sul UFRGS, Dept Pharmacol, Porto Alegre, RS, Brazil
Univ Fed Rio Grande Sul UFRGS, Postgrad Program Pharmacol & Therapeut, Porto Alegre, RS, Brazil
Mezquida, G:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Cabrera, B:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Ribeiro, M:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Molina, M:
Univ Complutense Madrid, Sch Psychol, Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
Bioque, M:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Lobo, A:
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
Zaragoza Univ, Inst Invest Sanitaria Aragon IIS Aragon, Dept Med & Psychiat, Zaragoza, Spain
Gonzalez-Pinto, A:
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
Univ Basque Country, UPV EHU, Hosp Univ Alava Sede Santiago, Bioaraba Res Inst,Dept Psychiat, Barcelona, Spain
Fraguas, D:
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
Univ Complutense, Univ Gregorio Maranon, Hosp Gen,IiSGM,Sch Med, Dept Child & Adolescent Psychiat,Inst Psychiat &, Madrid, Spain
Corripio, I:
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
Univ Autonoma Barcelona UAB, Inst Invest Biomed St Pau IIB SANT PAU, Hosp Santa Creu & St Pau, Psychiat Dept, Barcelona, Spain
Vieta, E:
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
de la Serna, E:
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Univ Barcelona, Hosp Clin Barcelona, Inst Neurosci, Child & Adolescent Psychiat & Psychol Dept,Dept M, 2017SGR881, Barcelona, Spain
Morro, L:
Hosp Mar, Dept Psychiat, Barcelona, Spain
Garriga, M:
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Torrent, C:
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
Univ Barcelona, Inst Neurosci, Bipolar & Depress Disorders Unit, Barcelona, Catalonia, Spain
Cuesta, MJ:
Complejo Hosp Navarra, Dept Psychiat, Pamplona, Spain
Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
Bernardo, M:
Univ Barcelona, Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin,Schizophrenia Unit, Barcelona, Spain
Biomed Res Networking Ctr Mental Hlth Network CIB, Barcelona, Spain
August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain
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