Posterior Cervical Brown Fat and CXCL14 Levels in the First Year of Life: Sex Differences and Association With Adiposity
Por:
Garcia-Beltran, C, Cereijo, R, Plou, C, Gavalda-Navarro, A, Malpique, R, Villarroya, J, Lopez-Bermejo, A, de Zegher, F, Ibanez, L, Villarroya, F
Publicada:
17 feb 2022
Ahead of Print:
1 nov 2021
Resumen:
Context Brown adipose tissue (BAT) is particularly abundant in neonates, but its association with measures of adiposity and metabolic health in early infancy is poorly delineated. Besides sustaining nonshivering thermogenesis, BAT secretes brown adipokines that act on systemic metabolism. The chemokine CXCL14 has been identified as a brown adipokine in experimental studies. Objective To determine the relationships among BAT activity, adiposity, and circulating CXCL14 levels in the first year of life in girls and boys. Methods Indices of fat accretion, circulating endocrine-metabolic parameters and serum CXCL14 levels were assessed longitudinally in a cohort of infants at birth and at 4 and 12 months. BAT activity was estimated using infrared thermography only at age 12 months. The main outcome measures were weight and length Z-scores, total and abdominal fat content (by dual X-ray absorptiometry), BAT activity at the posterior cervical and supraclavicular regions, serum levels of glucose, insulin, insulin-like growth factor-I, high-molecular-weight adiponectin, and CXCL14; CXCL14 transcript levels in neonatal BAT and liver. Results Posterior cervical BAT was more active in girls than in boys (P = .02). BAT activity was negatively associated with adiposity parameters only in girls. CXCL14 levels were higher in girls than in boys at age 12 months and correlated positively with the area of active posterior cervical BAT in girls. Neonatal BAT showed high CXCL14 gene expression levels. Conclusion BAT activity and the levels of CXCL14-a potential surrogate of BAT activity-are sex specific in the first year of life. Posterior cervical BAT activity associates negatively with indices of adiposity only in girls.
Filiaciones:
Garcia-Beltran, C:
Univ Barcelona, Endocrinol Dept, Res Inst St Joan Deu, Barcelona 08950, Spain
ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain
Cereijo, R:
Univ Barcelona, Biochem & Mol Biomed Dept, Inst Biomed, Barcelona 08028, Spain
Res Inst St Joan Deu, Avda Diagonal 643, Barcelona 08028, Spain
ISCIII, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
Hosp Santa Creu & Sant Pau, Dept Infect Dis, Barcelona, Spain
Plou, C:
Univ Barcelona, Endocrinol Dept, Res Inst St Joan Deu, Barcelona 08950, Spain
Gavalda-Navarro, A:
Univ Barcelona, Biochem & Mol Biomed Dept, Inst Biomed, Barcelona 08028, Spain
Res Inst St Joan Deu, Avda Diagonal 643, Barcelona 08028, Spain
ISCIII, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
Malpique, R:
Univ Barcelona, Endocrinol Dept, Res Inst St Joan Deu, Barcelona 08950, Spain
ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain
Villarroya, J:
Univ Barcelona, Biochem & Mol Biomed Dept, Inst Biomed, Barcelona 08028, Spain
Res Inst St Joan Deu, Avda Diagonal 643, Barcelona 08028, Spain
ISCIII, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
Lopez-Bermejo, A:
Dr Josep Trueta Hosp, Dept Pediat, Girona 17007, Spain
Girona Inst Biomed Res, Girona 17007, Spain
de Zegher, F:
Univ Leuven, Dept Dev & Regenerat, B-3000 Leuven, Belgium
Ibanez, L:
Univ Barcelona, Endocrinol Dept, Res Inst St Joan Deu, Barcelona 08950, Spain
ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain
Villarroya, F:
Univ Barcelona, Biochem & Mol Biomed Dept, Inst Biomed, Barcelona 08028, Spain
Res Inst St Joan Deu, Avda Diagonal 643, Barcelona 08028, Spain
ISCIII, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain
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