Plasma sICAM-1 as a Biomarker of Carotid Plaque Inflammation in Patients with a Recent Ischemic Stroke
Por:
Puig, N, Camps-Renom, P, Camacho, M, Aguilera-Simon, A, Jimenez-Altayo, F, Fernandez-Leon, A, Marin, R, Marti-Fabregas, J, Sanchez-Quesada, JL, Jimenez-Xarrie, E, Benitez, S
Publicada:
1 oct 2022
Ahead of Print:
1 mar 2022
Resumen:
F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG PET) identifies carotid plaque inflammation and predicts stroke recurrence in patients with atherothrombotic stroke. The aim of the study was to identify plasma inflammatory biomarkers associated with plaque inflammation according to F-18-FDG uptake. We conducted a prospective study of consecutive adult patients with a recent (< 7 days) anterior circulation ischemic stroke and at least one atherosclerotic plaque in the ipsilateral internal carotid artery. We included 64 patients, 57.8% of whom showed a carotid stenosis >= 50%. All patients underwent an early (< 15 days from inclusion) F-18-FDG PET, and a blood sample was obtained at days 7 +/- 1 from the stroke. The plasma concentration of 16 inflammation-related molecules was analyzed in a Luminex using xMAP technology. Multivariable linear regression was used to assess the association between plasma biomarkers and the standardized uptake value (SUV) of F-18-FDG uptake. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), and fractalkine (FKN) were independently associated with plaque inflammation (beta = 0.121, 95% CI 0.061-0.181, p < 0.001; beta = 0.144, 95% CI 0.012-0.276, p = 0.033; beta = 0.136, 95% CI 0.037-0.235, p = 0.008). In a multivariable logistic regression analysis, sICAM-1 was associated with SUVmax >= 2.85 (OR = 1.02, 95% CI 1.00-1.03, p = 0.020). Multivariable Cox regression was used to assess the association between biomarkers and stroke recurrence. sICAM-1 was associated with stroke recurrence (HR = 1.03, 95% CI 1.00-1.05, p = 0.002). In summary, elevated concentrations of sICAM-1 were associated with carotid plaque inflammation and an increased risk of stroke recurrence in patients with recent ischemic stroke and carotid atherosclerosis.
Filiaciones:
Puig, N:
Biomed Res Inst St Pau IIB St Pau, Cardiovasc Biochem, Barcelona, Spain
Univ Autonoma Barcelona UAB, Fac Med, Dept Biochem & Mol Biol, Bldg M, Barcelona, Spain
Camps-Renom, P:
IIB St Pau, Stroke Unit, Hosp Santa Creu & St Pau, Dept Neurol, Barcelona, Spain
Camacho, M:
Biomed Res Inst St Pau IIB St Pau, Genet Complexes Dis, Barcelona, Spain
Aguilera-Simon, A:
IIB St Pau, Stroke Unit, Hosp Santa Creu & St Pau, Dept Neurol, Barcelona, Spain
Jimenez-Altayo, F:
UAB, Neurosci Inst, Dept Pharmacol, Fac Med, Barcelona, Spain
Fernandez-Leon, A:
IIB St Pau, Hosp Santa Creu & St Pau, Dept Nucl Med, Barcelona, Spain
Marin, R:
IIB St Pau, Stroke Unit, Hosp Santa Creu & St Pau, Dept Neurol, Barcelona, Spain
Marti-Fabregas, J:
IIB St Pau, Stroke Unit, Hosp Santa Creu & St Pau, Dept Neurol, Barcelona, Spain
Sanchez-Quesada, JL:
Biomed Res Inst St Pau IIB St Pau, Cardiovasc Biochem, Barcelona, Spain
CIBER Diabet & Metab Dis CIBERDEM, Madrid, Spain
Jimenez-Xarrie, E:
IIB St Pau, Stroke Unit, Hosp Santa Creu & St Pau, Dept Neurol, Barcelona, Spain
Benitez, S:
Biomed Res Inst St Pau IIB St Pau, Cardiovasc Biochem, Barcelona, Spain
hybrid, All Open Access; Hybrid Gold
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