New developments of biofluid-based biomarkers for routine diagnosis and disease trajectories in frontotemporal dementia
Por:
del Campo, M, Zetterberg, H, Gandy, S, Onyike, CU, Oliveira, F, Udeh-Momoh, C, Lleo, A, Teunissen, CE, Pijnenburg, Y
Publicada:
1 nov 2022
Ahead of Print:
1 mar 2022
Resumen:
Frontotemporal dementia (FTD) covers a spectrum of neurodegenerative disorders with different phenotypes, genetic backgrounds, and pathological states. Its clinicopathological diversity challenges the diagnostic process and the execution of clinical trials, calling for specific diagnostic biomarkers of pathologic FTD types. There is also a need for biomarkers that facilitate disease staging, quantification of severity, monitoring in clinics and observational studies, and for evaluation of target engagement and treatment response in clinical trials. This review discusses current FTD biofluid-based biomarker knowledge taking into account the differing applications. The limitations, knowledge gaps, and challenges for the development and implementation of such markers are also examined. Strategies to overcome these hurdles are proposed, including the technologies available, patient cohorts, and collaborative research initiatives. Access to robust and reliable biomarkers that define the exact underlying pathophysiological FTD process will meet the needs for specific diagnosis, disease quantitation, clinical monitoring, and treatment development.
Filiaciones:
del Campo, M:
Univ San Pablo CEU, CEU Univ, Fac Farm, Dept Ciencias Farmaceut & Salud, Madrid, Spain
Zetterberg, H:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
UCL, UK Dementia Res Inst, London, England
UCL, Inst Neurol, Dept Neurodegenerat Dis, London, England
Hong Kong Ctr Neurodegenerat Dis, Hong Kong, Peoples R China
Gandy, S:
Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA
Onyike, CU:
Johns Hopkins Univ, Sch Med, Div Geriatr Psychiat & Neuropsychiat, Baltimore, MD USA
Oliveira, F:
Fed Univ Sao Paulo UNIFESP, Escola Paulista Med, Dept Neurol & Neurosurg, Sao Paulo, SP, Brazil
Udeh-Momoh, C:
Imperial Coll London, Fac Med, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England
Univ Bristol, Fac Med, Translat Hlth Sci, Bristol, Avon, England
Lleo, A:
Hosp Santa Creu & Sant Pau, Neurol Dept, Barcelona, Spain
Teunissen, CE:
Vrije Univ, Amsterdam Univ Med Ctr, Amsterdam Neurosci, Neurochem Lab,Dept Clin Chem, Amsterdam, Netherlands
Pijnenburg, Y:
Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Neurosci, Alzheimer Ctr Amsterdam,Dept Neurol, Amsterdam, Netherlands
Green Published, hybrid, Green
|