Staging Parkinson's Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life
Por:
Garcia, DS, Fonticoba, TDD, Gonzalez, JMP, Bartolome, CC, Aymerich, LV, Enriquez, JGM, Suarez, E, Jesus, S, Aguilar, M, Pastor, P, Planellas, LL, Cosgaya, M, Caldentey, JG, Caballol, N, Legarda, I, Vara, JH, Cabo, I, Manzanares, LL, Aramburu, IG, Rivera, MAA, Catalan, MJ, Nogueira, V, Puente, V, Moreno, JMG, Borrue, C, Vila, BS, Sauco, MA, Vela, L, Escalante, S, Cubo, E, Padilla, FC, Castrillo, JCM, Alonso, PS, Losada, MG, Ariztegui, NL, Gaston, I, Kulisevsky, J, Estrada, MB, Seijo, M, Martinez, JR, Valero, C, Kurtis, M, de Fabregues, O, Ardura, JG, Ordas, C, Diaz, LL, Mir, P, Martinez-Martin, P
Publicada:
15 may 2021
Resumen:
Introduction. In a degenerative disorder such as Parkinson's disease (PD), it is important to establish clinical stages that allow to know the course of the disease. Our aim was to analyze whether a scale combining Hoehn and Yahr's motor stage (H&Y) and the nonmotor symptoms burden (NMSB) (assessed by the nonmotor symptoms scale (NMSS)) provides information about the disability and the patient's quality of life (QoL) with regard to a defined clinical stage. Materials and Methods. Cross-sectional study in which 603 PD patients from the COPPADIS cohort were classified according to H&Y (1, stage I; 2, stage II; 3, stage III; 4, stage IV/V) and NMSB (A: NMSS=0-20; B: NMSS=21-40; C: NMSS=41-70; D: NMSS >= 71) in 16 stages (HY.NMSB, from 1A to 4D). QoL was assessed with the PDQ-39SI, PQ-10, and EUROHIS-QOL8 and disability with the Schwab&England ADL (Activities of Daily Living) scale. Results. A worse QoL and greater disability were observed at a higher stage of H&Y and NMSB (p<0.0001). Combining both (HY.NMSB), patients in stages 1C and 1D and 2C and 2D had significantly worse QoL and/or less autonomy for ADL than those in stages 2A and 2B and 3A and 3B, respectively (p<0.005; e.g., PDQ-39SI in 1D [n=15] vs 2A [n=101]: 28.6 +/- 17.1 vs 7.9 +/- 5.8; p<0.0001). Conclusion. The HY.NMSB scale is simple and reflects the degree of patient involvement more accurately than the H&Y. Patients with a lower H&Y stage may be more affected if they have a greater NMS burden.
Filiaciones:
Garcia, DS:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Fonticoba, TDD:
Complejo Hosp Univ Ferrol, CHUF, La Coruna, Spain
Gonzalez, JMP:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Bartolome, CC:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Aymerich, LV:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Enriquez, JGM:
Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
Suarez, E:
Complejo Hosp Univ Ferrol, CHUF, La Coruna, Spain
Jesus, S:
Univ Seville, Serv Neurol & Neurofisiol Clin, Unidad Trastornos Movimiento, Hosp Univ Virgen Rocio,CSIC,Inst Biomed Sevilla, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain
Aguilar, M:
Hosp Univ Mutua Terrassa, Terrassa, Spain
Pastor, P:
Hosp Univ Mutua Terrassa, Terrassa, Spain
Planellas, LL:
Hosp Clin Barcelona, Barcelona, Spain
Cosgaya, M:
Hosp Clin Barcelona, Barcelona, Spain
Caldentey, JG:
Ctr Neurol Oms 42, Palma de Mallorca, Spain
Caballol, N:
Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
Legarda, I:
Hosp Univ Son Espases, Palma De Mallorca, Spain
Vara, JH:
Hosp Univ Vall Hebron, Barcelona, Spain
Cabo, I:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Manzanares, LL:
Hosp Univ La Princesa, Madrid, Spain
Aramburu, IG:
Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain
Hosp Univ Marques Valdecilla, Santander, Spain
Rivera, MAA:
Hosp Gen Hosp, Consorci Sanitari Integral, Barcelona, Spain
Catalan, MJ:
Hosp Univ Clin San Carlos, Madrid, Spain
Nogueira, V:
Hosp Da Costa, Lugo, Spain
Puente, V:
Hosp del Mar, Barcelona, Spain
Moreno, JMG:
Hosp Univ Virgen Macarena, Seville, Spain
Borrue, C:
Hosp Infanta Sofia, Madrid, Spain
Vila, BS:
Inst Catala Salut, Inst Assistencia Sanitaria IAS, Girona, Spain
Sauco, MA:
Hosp Gen Univ Elche, Elche, Spain
Vela, L:
Fdn Hosp Alcorcon, Madrid, Spain
Escalante, S:
Hosp Tortosa Verge Cinta IITVC, Tarragona, Spain
Cubo, E:
Complejo Asistencial Univ Burgos, Burgos, Spain
Padilla, FC:
Hosp Univ Canarias, San Cristobal De Laguna, Santa Cruz De T, Spain
Castrillo, JCM:
Hosp Univ Ramon y Cajal, Madrid, Spain
Alonso, PS:
Hosp Univ Puerta Hierro, Madrid, Spain
Losada, MG:
Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain
Ariztegui, NL:
Complejo Hosp Toledo, Toledo, Spain
Gaston, I:
Complejo Hosp Navarra, Pamplona, Spain
Kulisevsky, J:
Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain
Hosp Santa Creu & Sant Pau, Barcelona, Spain
Estrada, MB:
Hosp Univ Cent Asturias, Oviedo, Spain
Seijo, M:
Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
Martinez, JR:
Hosp Univ Donostia, San Sebastian, Spain
Valero, C:
Hosp Arnau Vilanova, Valencia, Spain
Kurtis, M:
Hosp Ruber Int, Madrid, Spain
de Fabregues, O:
Hosp Univ Vall Hebron, Barcelona, Spain
Ardura, JG:
Hosp Univ Lucus Augusti HULA, Lugo, Spain
Ordas, C:
Hosp Rey Juan Carlos, Madrid, Spain
Diaz, LL:
Complejo Hosp Univ Orense CHUO, Orense, Spain
Mir, P:
Univ Seville, Serv Neurol & Neurofisiol Clin, Unidad Trastornos Movimiento, Hosp Univ Virgen Rocio,CSIC,Inst Biomed Sevilla, Seville, Spain
Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain
Martinez-Martin, P:
Ctr Invest Biomed Red Enfermedades Neurodegnerat, CIBERNED, Madrid, Spain
gold, Green Published
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