The Predictive Value of miR-16,-29a and-134 for Early Identification of Gestational Diabetes: A Nested Analysis of the DALI Cohort
Por:
Sorensen, AE, van Poppel, MNM, Desoye, G, Damm, P, Simmons, D, Jensen, DM, Dalgaard, LT, Corcoy R., DALI Core Investigator Grp
Publicada:
1 ene 2021
Resumen:
Early identification of gestational diabetes mellitus (GDM) aims to reduce the risk of adverse maternal and perinatal outcomes. Currently, no circulating biomarker has proven clinically useful for accurate prediction of GDM. In this study, we tested if a panel of small non-coding circulating RNAs could improve early prediction of GDM. We performed a nested case-control study of participants from the European multicenter 'Vitamin D and lifestyle intervention for GDM prevention (DALI)' trial using serum samples from obese pregnant women (BMI >= 29 kg/m(2)) entailing 82 GDM cases (early- and late- GDM), and 41 age- and BMI-matched women with normal glucose tolerance (NGT) throughout pregnancy (controls). Anthropometric, clinical and biochemical characteristics were obtained at baseline (<20 weeks of gestation) and throughout gestation. Baseline serum microRNAs (miRNAs) were measured using quantitative real time PCR (qPCR). Elevated miR-16-5p, -29a-3p, and -134-5p levels were observed in women, who were NGT at baseline and later developed GDM, compared with controls who remained NGT. A combination of the three miRNAs could distinguish later GDM from NGT cases (AUC 0.717, p = 0.001, compared with fasting plasma glucose (AUC 0.687, p = 0.004)) as evaluated by area under the curves (AUCs) using Receiver Operator Characteristics (ROC) analysis. Elevated levels of individual miRNAs or a combination hereof were associated with higher odds ratios of GDM. Conclusively, circulating miRNAs early in pregnancy could serve as valuable predictive biomarkers of GDM.
Filiaciones:
Sorensen, AE:
Roskilde Univ, Dept Sci & Environm, DK-4000 Roskilde, Denmark
van Poppel, MNM:
Karl Franzens Univ Graz, Inst Human Movement Sci Sport & Hlth, A-8010 Graz, Austria
Desoye, G:
Med Univ Graz, Dept Obstet & Gynecol, A-8036 Graz, Austria
Univ Copenhagen, Ctr Pregnant Women Diabet, Dept Obstet, Rigshosp,Dept Clin Med, DK-2100 Copenhagen, Denmark
Damm, P:
Univ Copenhagen, Ctr Pregnant Women Diabet, Dept Obstet, Rigshosp,Dept Clin Med, DK-2100 Copenhagen, Denmark
Simmons, D:
Western Sydney Univ, Macarthur Clin Sch, Sydney, NSW 2560, Australia
Jensen, DM:
Odense Univ Hosp, Dept Gynecol & Obstet, Steno Diabet Ctr Odense, DK-5000 Odense, Denmark
Odense Univ Hosp, Dept Gynecol & Obstet, DK-5000 Odense, Denmark
Univ Southern Denmark, Dept Clin Res, Fac Hlth Sci, DK-5000 Odense, Denmark
Dalgaard, LT:
Roskilde Univ, Dept Sci & Environm, DK-4000 Roskilde, Denmark
Corcoy R.:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Green Published, gold
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