The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
Por:
Lima, RA, Desoye, G, Simmons, D, Devlieger, R, Galjaard, S, Corcoy, R, Adelantado, JM, Dunne, F, Harreiter, J, Kautzky-Willer, A, Damm, P, Mathiesen, ER, Jensen, DM, Andersen, LLT, Tanvig, M, Lapolla, A, Dalfra, MG, Bertolotto, A, Manta, U, Wender-Ozegowska, E, Zawiejska, A, Hill, DJ, Snoek, FJ, Jelsma, JGM, van Poppel, M
Publicada:
1 ene 2021
Ahead of Print:
1 abr 2020
Resumen:
Background Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity.
Objectives To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed.
Methods This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (<20, 24-28, and 35-37 weeks of gestation). Offspring neonatal adiposity was estimated by the sum of four skinfolds. Structural equation modelling was conducted to evaluate the direct and indirect relationships among the variables of interest.
Results Data on 657 mother-infant pairs (50.7% boys) were analysed. Neonatal boys exhibited lower mean sum of skinfolds compared to girls (20.3 mm, 95% CI 19.7, 21.0 vs 21.5 mm, 95% CI 20.8, 22.2). In boys, maternal HOMA-IR at <20 weeks was directly associated with neonatal adiposity (beta = 0.35 mm, 95% CI 0.01, 0.70). In girls, maternal HOMA-IR at 24-28 weeks was only indirectly associated with neonatal adiposity, which implies that this association was mediated via maternal HOMA-IR, glucose, triglycerides, and NEFA during pregnancy (beta = 0.26 mm, 95% CI 0.08, 0.44).
Conclusions The timing of the role of maternal insulin resistance on neonatal adiposity depends on fetal sex. Although the association was time-dependent, maternal insulin resistance was associated with neonatal adiposity in both sexes.
Filiaciones:
Lima, RA:
Karl Franzens Univ Graz, Inst Sport Sci, Graz, Austria
Desoye, G:
Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria
Simmons, D:
Western Sydney Univ, Campbelltown, NSW, Australia
Addenbrookes Hosp, Inst Metab Sci, Cambridge, England
Devlieger, R:
Katholieke Univ Leuven, Univ Hosp Leuven, Dept Dev & Regenerat Pregnancy Fetus & Neonate Gy, Leuven, Belgium
Galjaard, S:
Katholieke Univ Leuven, Univ Hosp Leuven, Dept Dev & Regenerat Pregnancy Fetus & Neonate Gy, Leuven, Belgium
Erasmus MC, Dept Obstet & Gynaecol, Univ Med Ctr Rotterdam, Div Obstet & Prenatal Med, Rotterdam, Netherlands
Corcoy, R:
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain
Inst Salud Carlos III, CIBER Bioengn Biomat & Nanotechnol, Zaragoza, Spain
Adelantado, JM:
Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain
Inst Salud Carlos III, CIBER Bioengn Biomat & Nanotechnol, Zaragoza, Spain
Dunne, F:
Natl Univ Ireland, Galway Diabet Res Ctr, Galway, Ireland
Natl Univ Ireland, Coll Med Nursing & Hlth Sci, Galway, Ireland
Harreiter, J:
Med Univ Vienna, Dept Internal Med 3, Endocrinol & Metab, Gender Med Unit, Vienna, Austria
Kautzky-Willer, A:
Med Univ Vienna, Dept Internal Med 3, Endocrinol & Metab, Gender Med Unit, Vienna, Austria
Damm, P:
Univ Copenhagen, Rigshosp, Fac Hlth & Med Sci, Ctr Pregnant Women Diabet,Dept Endocrinol, Copenhagen, Denmark
Univ Copenhagen, Rigshosp, Fac Hlth & Med Sci, Ctr Pregnant Women Diabet,Dept Obstet, Copenhagen, Denmark
Mathiesen, ER:
Univ Copenhagen, Rigshosp, Fac Hlth & Med Sci, Ctr Pregnant Women Diabet,Dept Endocrinol, Copenhagen, Denmark
Univ Copenhagen, Rigshosp, Fac Hlth & Med Sci, Ctr Pregnant Women Diabet,Dept Obstet, Copenhagen, Denmark
Jensen, DM:
Univ Southern Denmark, Odense Univ Hosp, Dept Gynecol & Obstet, Odense, Denmark
Univ Southern Denmark, Odense Univ Hosp, Fac Hlth Sci, Steno Diabet Ctr Odense,Dept Clin Res, Odense, Denmark
Andersen, LLT:
Univ Southern Denmark, Odense Univ Hosp, Dept Gynecol & Obstet, Odense, Denmark
Univ Southern Denmark, Fac Hlth Sci, Dept Clin Res, Odense, Denmark
Tanvig, M:
Univ Southern Denmark, Odense Univ Hosp, Dept Gynecol & Obstet, Odense, Denmark
Univ Southern Denmark, Fac Hlth Sci, Dept Clin Res, Odense, Denmark
Lapolla, A:
Univ Padua, Padua, Italy
Dalfra, MG:
Univ Padua, Padua, Italy
Bertolotto, A:
Azienda Osped Univ Pisa, Pisa, Italy
Manta, U:
Poznan Univ Med Sci, Dept Reprod, Poznan, Poland
Wender-Ozegowska, E:
Poznan Univ Med Sci, Dept Reprod, Poznan, Poland
Zawiejska, A:
Poznan Univ Med Sci, Dept Reprod, Poznan, Poland
Hill, DJ:
Rech Sante Lawson SA, Bronschhofen, Switzerland
Snoek, FJ:
Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Med Psychol, Amsterdam UMC, Amsterdam, Netherlands
Jelsma, JGM:
Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam UMC, Amsterdam, Netherlands
van Poppel, M:
Karl Franzens Univ Graz, Inst Sport Sci, Graz, Austria
Green Published, hybrid
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