Association between coffee consumption and total dietary caffeine intake with cognitive functioning: cross-sectional assessment in an elderly Mediterranean population
Por:
Paz-Graniel, I, Babio, N, Becerra-Tomas, N, Toledo, E, Camacho-Barcia, L, Corella, D, Castaner-Nino, O, Romaguera, D, Vioque, J, Alonso-Gomez, AM, Warnberg, J, Martinez, JA, Serra-Majem, L, Estruch, R, Tinahones, FJ, Fernandez-Aranda, F, Lapetra, J, Pinto, X, Tur, JA, Garcia-Rios, A, Bueno-Cavanillas, A, Gaforio, JJ, Matia-Martin, P, Daimiel, L, Sanchez, VM, Vidal, J, Prieto-Sanchez, L, Ros, E, Razquin, C, Mestres, C, Sorli, JV, Cuenca-Royo, AM, Rios, A, Torres-Collado, L, Vaquero-Luna, J, Perez-Farinos, N, Zulet, MA, Sanchez-Villegas, A, Casas, R, Bernal-Lopez, MR, Santos-Lozano, JM, Corbella, X, Mateos, D, Buil-Cosiales, P, Jimenez-Murcia, S, Fernandez-Carrion, R, Forcano-Gamazo, L, Lopez, M, Sempere-Pascual, MA, Moreno-Rodriguez, A, Gea, A, De la Torre-Fornell, R, Salas-Salvado, J, Perez, A, Lozano Madrid, Maria
Publicada:
1 ago 2021
Ahead of Print:
1 oct 2020
Resumen:
Purpose Coffee is rich in compounds such as polyphenols, caffeine, diterpenes, melanoidins and trigonelline, which can stimulate brain activity. Therefore, the possible association of coffee consumption with cognition is of considerable research interest. In this paper, we assess the association of coffee consumption and total dietary caffeine intake with the risk of poor cognitive functioning in a population of elderly overweight/obese adults with metabolic syndrome (MetS). Methods PREDIMED-plus study participants who completed the Mini-Mental State Examination test (MMSE) (n = 6427; mean age = 65 +/- 5 years) or a battery of neuropsychological tests were included in this cross-sectional analysis. Coffee consumption and total dietary caffeine intake were assessed at baseline using a food frequency questionnaire. Logistic regression models were fitted to evaluate the association between total, caffeinated and decaffeinated coffee consumption or total dietary caffeine intake and cognitive impairment. Results Total coffee consumers and caffeinated coffee consumers had better cognitive functioning than non-consumers when measured by the MMSE and after adjusting for potential confounders (OR 0.63; 95% CI 0.44-0.90 and OR 0.56; 95% CI 0.38-0.83, respectively). Results were similar when cognitive performance was measured using the Clock Drawing Test (CDT) and Trail Making Test B (TMT-B). These associations were not observed for decaffeinated coffee consumption. Participants in the highest tertile of total dietary caffeine intake had lower odds of poor cognitive functioning than those in the reference tertile when screened by the MMSE (OR 0.64; 95% CI 0.47-0.87) or other neurophysiological tests evaluating a variety of cognitive domains (i.e., CDT and TMT-A). Conclusions Coffee consumption and total dietary caffeine intake were associated with better cognitive functioning as measured by various neuropsychological tests in a Mediterranean cohort of elderly individuals with MetS.
Filiaciones:
Paz-Graniel, I:
Rovira & Virgili Univ, Dept Biochem & Biotechnol, Human Nutr Unit, Reus, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Babio, N:
Rovira & Virgili Univ, Dept Biochem & Biotechnol, Human Nutr Unit, Reus, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Becerra-Tomas, N:
Rovira & Virgili Univ, Dept Biochem & Biotechnol, Human Nutr Unit, Reus, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain
Toledo, E:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona, Spain
Camacho-Barcia, L:
Rovira & Virgili Univ, Dept Biochem & Biotechnol, Human Nutr Unit, Reus, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Corella, D:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Valencia, Dept Prevent Med, Valencia, Spain
Castaner-Nino, O:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Hosp del Mar Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp CARIN, Barcelona, Spain
Romaguera, D:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Hosp del Mar Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp CARIN, Barcelona, Spain
Vioque, J:
Carlos III Hlth Inst, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain
Miguel Hernandez Univ, ISABIAL UMH, Alicante, Spain
Alonso-Gomez, AM:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain
Warnberg, J:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Malaga, Sch Hlth Sci, Dept Nursing, Inst Invest Biomed Malaga IBIMA, Malaga, Spain
Martinez, JA:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Navarra, Dept Nutr Food Sci & Physiol, IDISNA, Pamplona, Spain
CSIC, Nutr Genom & Epigen Grp, IMDEA Food, CEI UAM, Madrid, Spain
Serra-Majem, L:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Ctr Hosp Univ Insular Materno Infantil CHUIMI, Prevent Med Serv,Canarian Hlth Serv, Las Palmas Gran Canaria, Spain
Estruch, R:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin, Dept Internal Med, Barcelona, Spain
Tinahones, FJ:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Malaga, Virgen Victoria Hosp, Dept Endocrinol, Biomed Res Inst Malaga IBIMA, Malaga, Spain
Fernandez-Aranda, F:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Bellvitge Univ Hosp, IDIBELL, Dept Psychiat, Barcelona, Spain
Lapetra, J:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Distrito Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain
Pinto, X:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Bellvitge Univ Hosp, Internal Med, Lipids & Vasc Risk Unit, Barcelona, Spain
Tur, JA:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Hosp Son Espases, Hlth Res Inst Balear Islands IdISBa, Palma De Mallorca, Spain
Univ Balear Islands, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain
Garcia-Rios, A:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba, Spain
Bueno-Cavanillas, A:
Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain
Univ Granada, Dept Prevent Med, Granada, Spain
Gaforio, JJ:
Carlos III Hlth Inst, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain
Univ Jaen, Dept Ciencias Salud, Ctr Estudios Avanzados Olivar & Aceites Oliva, Jaen, Spain
Matia-Martin, P:
San Carlos Clin Hosp IdISSC, Hlth Res Inst, Dept Endocrinol & Nutr, Madrid, Spain
Daimiel, L:
CSIC, Nutr Genom & Epigen Grp, IMDEA Food, CEI UAM, Madrid, Spain
Sanchez, VM:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Leon, Inst Biomed IBIOMED, Leon, Spain
Vidal, J:
Carlos III Hlth Inst ISCIII, CIBER Diabet & Associated Metab Dis CIBERDEM, Madrid, Spain
Univ Barcelona, August Pi & Sunyer Biomed Res Inst IDIBAPS, Hosp Clin, Dept Endocrinol, Barcelona, Spain
Prieto-Sanchez, L:
Fdn Jimenez Diaz, Dept Endocrinol, Madrid, Spain
Ros, E:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
August Pi & Sunyer Biomed Res Inst IDIBAPS, Hosp Clin, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain
Razquin, C:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona, Spain
Mestres, C:
Joan XXIII Univ Hosp, Tarragona, Spain
Horts Miro Hlth Ctr, Reus, Spain
Sorli, JV:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Valencia, Dept Prevent Med, Valencia, Spain
Cuenca-Royo, AM:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Hosp del Mar Res Inst IMIM, Integrat Pharmacol & Syst Neurosci FINS, Barcelona, Spain
Rios, A:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Hosp Son Espases, Hlth Res Inst Balear Islands IdISBa, Palma De Mallorca, Spain
Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba, Spain
Torres-Collado, L:
Carlos III Hlth Inst, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain
Miguel Hernandez Univ, ISABIAL UMH, Alicante, Spain
Vaquero-Luna, J:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain
Perez-Farinos, N:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Malaga, Sch Med, Dept Publ Hlth, Biomed Res Inst Malaga IBIMA, Malaga, Spain
Zulet, MA:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Navarra, Dept Nutr Food Sci & Physiol, IDISNA, Pamplona, Spain
Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona, Spain
Sanchez-Villegas, A:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Ctr Hosp Univ Insular Materno Infantil CHUIMI, Prevent Med Serv,Canarian Hlth Serv, Las Palmas Gran Canaria, Spain
Casas, R:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin, Dept Internal Med, Barcelona, Spain
Bernal-Lopez, MR:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Reg Univ Hosp Malaga, Inst Invest Biomed Malaga IBIMA, Internal Med Dept, Malaga, Spain
Santos-Lozano, JM:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Distrito Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain
Corbella, X:
Bellvitge Univ Hosp, Internal Med, Lipids & Vasc Risk Unit, Barcelona, Spain
Univ Int Catalunya, Med & Hlth Sci Fac, Barcelona, Spain
Mateos, D:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Carlos III Hlth Inst, CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain
Univ Balear Islands, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain
Buil-Cosiales, P:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona, Spain
Jimenez-Murcia, S:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Bellvitge Univ Hosp, IDIBELL, Dept Psychiat, Barcelona, Spain
Fernandez-Carrion, R:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Valencia, Dept Prevent Med, Valencia, Spain
Forcano-Gamazo, L:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Hosp del Mar Res Inst IMIM, Integrat Pharmacol & Syst Neurosci FINS, Barcelona, Spain
Lopez, M:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Hosp Son Espases, Hlth Res Inst Balear Islands IdISBa, Palma De Mallorca, Spain
Reg Univ Hosp Malaga, Inst Invest Biomed Malaga IBIMA, Internal Med Dept, Malaga, Spain
Sempere-Pascual, MA:
Santa Pola Hlth Ctr, Alicante, Spain
Moreno-Rodriguez, A:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain
Gea, A:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona, Spain
De la Torre-Fornell, R:
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Hosp del Mar Res Inst IMIM, Integrat Pharmacol & Syst Neurosci FINS, Barcelona, Spain
Salas-Salvado, J:
Rovira & Virgili Univ, Dept Biochem & Biotechnol, Human Nutr Unit, Reus, Spain
Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain
Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid, Spain
Sant Joan Univ Hosp, Human Nutr Unit, Reus, Spain
Perez, A:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Lozano Madrid, Maria:
Instituto de Salud Carlos III, Madrid, Spain
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