Behavioural and psychological symptoms of dementia in Down syndrome: Early indicators of clinical Alzheimer's disease?
Por:
Dekker, AD, Strydom, A, Coppus, AMW, Nizetic, D, Vermeiren, Y, Naude, PJW, Van Dam, D, Potier, MC, Fortea, J, De Deyn, PP
Publicada:
1 dic 2015
Resumen:
Behavioural and Psychological Symptoms of Dementia (BPSD) are a core symptom of dementia and are associated with suffering, earlier institutionalization and accelerated cognitive decline for patients and increased caregiver burden. Despite the extremely high risk for Down syndrome (DS) individuals to develop dementia due to Alzheimer's disease (AD), BPSD have not been comprehensively assessed in the DS population. Due to the great variety of DS cohorts, diagnostic methodologies, sub-optimal scales, covariates and outcome measures, it is questionable whether BPSD have always been accurately assessed. However, accurate recognition of BPSD may increase awareness and understanding of these behavioural aberrations, thus enabling adaptive caregiving and, importantly, allowing for therapeutic interventions. Particular BPSD can be observed (long) before the clinical dementia diagnosis and could therefore serve as early indicators of those at risk, and provide a new, non-invasive way to monitor, or at least give an indication of, the complex progression to dementia in DS. Therefore, this review summarizes and evaluates the rather limited knowledge on BPSD in DS and highlights its importance and potential for daily clinical practice. (C) 2015 Elsevier Ltd. All rights reserved.
Filiaciones:
Dekker, AD:
Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, Groningen, Netherlands
Univ Antwerp, Inst Born Bunge, Lab Neurochem & Behav, B-2020 Antwerp, Belgium
Strydom, A:
UCL, Div Psychiat, London, England
Coppus, AMW:
Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, NL-6525 ED Nijmegen, Netherlands
Nizetic, D:
Queen Mary Univ London, Barts & London Sch Med, Blizard Inst, London, England
Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 639798, Singapore
Vermeiren, Y:
Univ Antwerp, Inst Born Bunge, Lab Neurochem & Behav, B-2020 Antwerp, Belgium
Naude, PJW:
Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, Groningen, Netherlands
Van Dam, D:
Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, Groningen, Netherlands
Univ Antwerp, Inst Born Bunge, Lab Neurochem & Behav, B-2020 Antwerp, Belgium
Fortea, J:
Catalan Syndrome Fdn, Barcelona, Spain
Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona, Spain
De Deyn, PP:
Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, Groningen, Netherlands
Univ Antwerp, Inst Born Bunge, Lab Neurochem & Behav, B-2020 Antwerp, Belgium
Green Accepted
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