Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry
Por:
Ramos-Araque, ME, Siegler, JE, Ribo, M, Requena, M, Lopez, C, de Lera, M, Arenillas, JF, Perez, IH, Gomez-Vicente, B, Talavera, B, Portela, PC, Guillen, AN, Urra, X, Llull, L, Renu, A, Nguyen, TN, Jillella, D, Nahab, F, Nogueira, R, Haussen, D, Then, R, Thon, JM, Esparragoza, LR, Hernandez-Perez, M, Bustamante, A, Mansour, OY, Megahed, M, Hassan, T, Liebeskind, DS, Hassan, A, Bushnaq, S, Osman, M, Vazquez, AR, Ramos-Pachon, A, Zha, Alicia M.
Publicada:
30 ene 2021
Resumen:
Background and purposeCoronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology.MethodsWe explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20).ResultsOf the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p
Filiaciones:
Ramos-Araque, ME:
Hosp Univ Salamanca, Inst Biomed Res Salamanca, Dept Neurol, Salamanca, Spain
Hosp Clin Univ Valladolid, Dept Neurol, Valladolid, Spain
Siegler, JE:
Cooper Univ Hosp, Cooper Neurol Inst, Camden, NJ 08103 USA
Ribo, M:
Vall dHebron Res Inst, Dept Neurol, Stroke Unit, Barcelona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Requena, M:
Vall dHebron Res Inst, Dept Neurol, Stroke Unit, Barcelona, Spain
Univ Autonoma Barcelona, Dept Med, Barcelona, Spain
Lopez, C:
Hosp Clin Univ Valladolid, Dept Neurol, Valladolid, Spain
de Lera, M:
Hosp Clin Univ Valladolid, Dept Neurol, Valladolid, Spain
Arenillas, JF:
Hosp Clin Univ Valladolid, Dept Neurol, Valladolid, Spain
Perez, IH:
Hosp Clin Univ Valladolid, Dept Neurol, Valladolid, Spain
Gomez-Vicente, B:
Hosp Clin Univ Valladolid, Dept Neurol, Valladolid, Spain
Talavera, B:
Hosp Clin Univ Valladolid, Dept Neurol, Valladolid, Spain
Portela, PC:
Hosp Univ, Dept Neurol, Barcelona, Spain
Guillen, AN:
Hosp Univ, Dept Neurol, Barcelona, Spain
Urra, X:
Hosp Clin Barcelona, Dept Neurol, Barcelona, Spain
Llull, L:
Hosp Clin Barcelona, Dept Neurol, Barcelona, Spain
Renu, A:
Hosp Clin Barcelona, Dept Neurol, Barcelona, Spain
Nguyen, TN:
Boston Univ, Sch Med, Boston Med Ctr, Dept Neurol,Dept Radiol,Dept Neurosurg, Boston, MA 02118 USA
Jillella, D:
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Nahab, F:
Emory Univ, Sch Med, Dept Neurol, Atlanta, GA 30322 USA
Nogueira, R:
Grady Mem Hosp, Dept Neurol, Atlanta, GA USA
Haussen, D:
Grady Mem Hosp, Dept Neurol, Atlanta, GA USA
Then, R:
Cooper Univ Hosp, Cooper Neurol Inst, Camden, NJ 08103 USA
Thon, JM:
Cooper Univ Hosp, Cooper Neurol Inst, Camden, NJ 08103 USA
Esparragoza, LR:
Hosp Badalona Germans Trias & Pujol, Neurosci Dept, Stroke Unit, Barcelona, Spain
Hernandez-Perez, M:
Hosp Badalona Germans Trias & Pujol, Neurosci Dept, Stroke Unit, Barcelona, Spain
Bustamante, A:
Hosp Badalona Germans Trias & Pujol, Neurosci Dept, Stroke Unit, Barcelona, Spain
Mansour, OY:
Alexandria Univ, Stroke & Neurointervent Unit, Neurol Dept, Alexandria, Egypt
Megahed, M:
Alexandria Univ, Crit Care Dept, Alexandria, Egypt
Hassan, T:
Alexandria Univ, Stroke & Neurointervent Unit, Neurosurg Dept, Alexandria, Egypt
Liebeskind, DS:
Ronald Reagan UCLA Med Ctr, Dept Neurol, Los Angeles, CA USA
Hassan, A:
Valley Baptist Med Ctr, Dept Clin Neurosci Res, Harlingen, TX USA
Univ Texas Rio Grande Valley, Dept Neurol, Harlingen, TX USA
Bushnaq, S:
Bon Secours Mercy Hlth St Vincent Hosp, Neurosci Inst, Toledo, OH USA
Osman, M:
Bon Secours Mercy Hlth St Vincent Hosp, Neurosci Inst, Toledo, OH USA
Vazquez, AR:
Hosp Clin Barcelona, Dept Neurol, Barcelona, Spain
Ramos-Pachon, A:
Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU), Sant Quintí 77-79, 08041 Barcelona, Spain
Zha, Alicia M.:
Department of Neurology, McGovern Medical School, University of Texas Health Science Center
Green Published, gold
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