A multicentre validation study of the diagnostic value of plasma neurofilament light
Por:
Ashton, NJ, Janelidze, S, Al Khleifat, A, Leuzy, A, van der Ende, EL, Karikari, TK, Benedet, AL, Pascoal, TA, Lleo, A, Parnetti, L, Galimberti, D, Bonanni, L, Pilotto, A, Padovani, A, Lycke, J, Novakova, L, Axelsson, M, Velayudhan, L, Rabinovici, GD, Miller, B, Pariante, C, Nikkheslat, N, Resnick, SM, Thambisetty, M, Scholl, M, Fernandez-Eulate, G, Gil-Bea, FJ, de Munain, AL, Al-Chalabi, A, Rosa-Neto, P, Strydom, A, Svenningsson, P, Stomrud, E, Santillo, A, Aarsland, D, van Swieten, JC, Palmqvist, S, Zetterberg, H, Blennow, K, Hye, A, Hansson, O
Publicada:
7 jun 2021
Resumen:
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King's College London (n=805) and the Swedish BioFINDER study (n=1,464). Plasma NfL was significantly increased in all cortical neurodegenerative disorders, amyotrophic lateral sclerosis and atypical parkinsonian disorders. We demonstrate that plasma NfL is clinically useful in identifying atypical parkinsonian disorders in patients with parkinsonism, dementia in individuals with Down syndrome, dementia among psychiatric disorders, and frontotemporal dementia in patients with cognitive impairment. Data-driven cut-offs highlighted the fundamental importance of age-related clinical cut-offs for disorders with a younger age of onset. Finally, plasma NfL performs best when applied to indicate no underlying neurodegeneration, with low false positives, in all age-related cut-offs. Cerebrospinal fluid neurofilament light (NfL) is a biomarker for neurodegeneration that can also be assessed in blood. Here the authors show in a validation study the potential for plasma NfL as a biomarker for several neurodegenerative diseases.
Filiaciones:
Ashton, NJ:
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Old Age Psychiat, London, England
South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr Mental Hlth, London, England
South London & Maudsley NHS Fdn, Biomed Res Unit, London, England
Janelidze, S:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Al Khleifat, A:
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England
Leuzy, A:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
van der Ende, EL:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Erasmus MC, Alzheimer Ctr, Rotterdam, Netherlands
Karikari, TK:
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
Benedet, AL:
McGill Univ, Res Ctr Studies Aging, Translat Neuroimaging Lab, Montreal, PQ, Canada
Montreal Neurol Inst, Montreal, PQ, Canada
Pascoal, TA:
McGill Univ, Res Ctr Studies Aging, Translat Neuroimaging Lab, Montreal, PQ, Canada
Montreal Neurol Inst, Montreal, PQ, Canada
Lleo, A:
Hosp Santa Creu & Sant Pau, Dept Neurol, Memory Unit, Montreal, PQ, Canada
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, CIBERNED, Madrid, Spain
Parnetti, L:
Univ Perugia, Lab Clin Neurochem, Neurol Clin, Perugia, Italy
Galimberti, D:
Osped Policlin, Fdn IRCCS Ca Granda, Milan, Italy
Univ Milan, Dino Ferrari Ctr, Milan, Italy
Bonanni, L:
Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy
Pilotto, A:
Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia, Italy
FERB ONLUS, Parkinsons Dis Rehabil Ctr, Trescore Balneario, BG, Italy
Padovani, A:
Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia, Italy
Lycke, J:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden
Sahlgrens Univ Hosp, Dept Neurol, Gothenburg, Sweden
Novakova, L:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden
Sahlgrens Univ Hosp, Dept Neurol, Gothenburg, Sweden
Axelsson, M:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden
Sahlgrens Univ Hosp, Dept Neurol, Gothenburg, Sweden
Velayudhan, L:
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Old Age Psychiat, London, England
Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
Rabinovici, GD:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA
Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA
Miller, B:
Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA
Pariante, C:
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Psychiat & Immunol Lab, London, England
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Perinatal Psychiat, London, England
Nikkheslat, N:
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Psychiat & Immunol Lab, London, England
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Perinatal Psychiat, London, England
Resnick, SM:
NIA, Brain Aging & Behav Sect, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA
Thambisetty, M:
NIA, Clin & Translat Neurosci Sect, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA
Scholl, M:
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, Gothenburg, Sweden
UCL, Dept Neurodegenerat Dis, Queen Sq Inst Neurol, London, England
Fernandez-Eulate, G:
Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Clin Neurosci, Gothenburg, Sweden
Biodonostia Hlth Res Inst, Neurosci Area, San Sebastian, Spain
Gil-Bea, FJ:
Biodonostia Hlth Res Inst, Neurosci Area, San Sebastian, Spain
Carlos III Hlth Inst, CIBERNED, Madrid, Spain
de Munain, AL:
Biodonostia Hlth Res Inst, Neurosci Area, San Sebastian, Spain
Donostia Univ Hosp, Dept Neurol, San Sebastian, Spain
Carlos III Hlth Inst, CIBERNED, Madrid, Spain
Univ Basque Country, Dept Neurosci, San Sebastian, Spain
Al-Chalabi, A:
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Basic & Clin Neurosci, London, England
Kings Coll Hosp London, Dept Neurol, London, England
Rosa-Neto, P:
McGill Univ, Res Ctr Studies Aging, Translat Neuroimaging Lab, Montreal, PQ, Canada
Montreal Neurol Inst, Montreal, PQ, Canada
Strydom, A:
Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Forens & Neurodev Sci, London, England
South London & Maudsley NHS Fdn Trust, London, England
London Syndrome Consortium LonDowns, London, England
Svenningsson, P:
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Old Age Psychiat, London, England
Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden
Stomrud, E:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Skane Univ Hosp, Memory Clin, Malmo, Sweden
Santillo, A:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Aarsland, D:
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Old Age Psychiat, London, England
South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr Mental Hlth, London, England
South London & Maudsley NHS Fdn, Biomed Res Unit, London, England
Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway
van Swieten, JC:
Erasmus MC, Dept Neurol, Rotterdam, Netherlands
Erasmus MC, Alzheimer Ctr, Rotterdam, Netherlands
Palmqvist, S:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Lund Univ, Skane Univ Hosp, Dept Neurol, Lund, Sweden
Zetterberg, H:
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
UCL, Dept Neurodegenerat Dis, Queen Sq Inst Neurol, London, England
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
UCL, UK Dementia Res Inst, London, England
Blennow, K:
Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, Molndal, Sweden
Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden
Hye, A:
Kings Coll London, Maurice Wohl Clin Neurosci Inst, Dept Old Age Psychiat, London, England
South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr Mental Hlth, London, England
South London & Maudsley NHS Fdn, Biomed Res Unit, London, England
Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway
Hansson, O:
Lund Univ, Dept Clin Sci Malmo, Clin Memory Res Unit, Lund, Sweden
Skane Univ Hosp, Memory Clin, Malmo, Sweden
Green Published, gold
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