Effect of tadalafil 5 mg daily treatment on penile haemodynamics in patients with erectile dysfunction
Por:
Gasanz, C, Moreno-Mendoza, D, Villegas, JF, Peraza, MF, Sarquella, J, Ruiz-Castane, E, Sanchez-Curbelo, J
Publicada:
1 ene 2022
Ahead of Print:
1 ene 2022
Resumen:
Introduction and objective: Phosphodiesterase-5 inhibitors (PDE-5) are the first-line treatment. ED diagnostic and evaluation methods are clinical: erection self-perception and evaluation questionnaires. It is necessary to identify predictive markers to choose the best drug and the best dose for each individual patient. This study seeks to evaluate the effect of tadalafil 5 mg daily treatment on penile haemodynamics (penis in flaccidity, using doppler ultrasound, without using alprostadil) and to study if these changes are clinically associated.
Material and methods: 40 patients who started treatment with tadalafil 5 mg daily were consecutively selected in a prospective study. Each patient underwent a penile doppler ultrasound and completed questionnaires (IIEF-6, EHS, SEP-2, SEP-3) at three different times: before starting the treatment, at 3 months and at 6 months (within the last 30 days without treatment).
Results and conclusions: Tadalafil 5 mg daily treatment for 3 months did not result in significant modifications to VPS and AS. There was clinical improvement according to the questionnaires after three months of treatment, which was not maintained at 6 months. Neither a clinical-radiological correlation nor a haemodynamic value predicting response to treatment could be established. (C) 2020 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.
Filiaciones:
Gasanz, C:
Parc Sanitari St Joan de Deu, Serv Urol, Barcelona, Spain
Moreno-Mendoza, D:
Fundacio Puigvert, Serv Androl, Barcelona, Spain
Villegas, JF:
Fundacio Puigvert, Serv Androl, Barcelona, Spain
Peraza, MF:
Fundacio Puigvert, Serv Androl, Barcelona, Spain
Sarquella, J:
Fundacio Puigvert, Serv Androl, Barcelona, Spain
Ruiz-Castane, E:
Fundacio Puigvert, Serv Androl, Barcelona, Spain
Sanchez-Curbelo, J:
Fundacio Puigvert, Serv Androl, Barcelona, Spain
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