Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients
Por:
Gutierrez, A, Zapater, P, Ricart, E, Gonzalez-Vivo, M, Gordillo, J, Olivares, D, Vera, I, Manosa, M, Gisbert, JP, Aguas, M, Sanchez-Rodriguez, E, Bosca-Watts, M, Laredo, V, Camps, B, Marin-Jimenez, I, Zabana, Y, Martin-Arranz, MD, Munoz, R, Navarro, M, Sierra, E, Madero, L, Vela, M, Perez-Calle, JL, Sainz, E, Calvet, X, Arias, L, Morales, V, Bermejo, F, Fernandez-Salazar, L, Van Domselaar, M, De Castro, L, Rodriguez, C, Munoz-Villafranca, C, Lorente, R, Rivero, M, Iglesias, E, Herreros, B, Busquets, D, Riera, J, Martinez-Montiel, MP, Roldon, M, Roncero, O, Hinojosa, E, Sierra, M, Barrio, J, De Francisco, R, Huguet, J, Merino, O, Carpio, D, Ginard, D, Munoz, F, Marta, P, Almela, P, Argueelles-Arias, F, Alcain, G, Luis, B, Mancenido, N, Lucendo, AJ, Varela, P, Rodriguez-Lago, I, Ramos, L, Laura, S, Sese, E, Acosta, MBD, Domenech, E, Frances, R
Publicada:
1 feb 2022
Resumen:
BackgroundPrevious studies comparing immigrant ethnic groups and native patients with IBD have yielded clinical and phenotypic differences. To date, no study has focused on the immigrant IBD population in Spain. MethodsProspective, observational, multicenter study comparing cohorts of IBD patients from ENEIDA-registry who were born outside Spain with a cohort of native patients. ResultsWe included 13,524 patients (1,864 immigrant and 11,660 native). The immigrants were younger (45 +/- 12 vs. 54 +/- 16 years, p < 0.001), had been diagnosed younger (31 +/- 12 vs. 36 +/- 15 years, p < 0.001), and had a shorter disease duration (14 +/- 7 vs. 18 +/- 8 years, p < 0.001) than native patients. Family history of IBD (9 vs. 14%, p < 0.001) and smoking (30 vs. 40%, p < 0.001) were more frequent among native patients. The most prevalent ethnic groups among immigrants were Caucasian (41.5%), followed by Latin American (30.8%), Arab (18.3%), and Asian (6.7%). Extraintestinal manifestations, mainly musculoskeletal affections, were more frequent in immigrants (19 vs. 11%, p < 0.001). Use of biologics, mainly anti-TNF, was greater in immigrants (36 vs. 29%, p < 0.001). The risk of having extraintestinal manifestations [OR: 2.23 (1.92-2.58, p < 0.001)] and using biologics [OR: 1.13 (1.0-1.26, p = 0.042)] was independently associated with immigrant status in the multivariate analyses. ConclusionsCompared with native-born patients, first-generation-immigrant IBD patients in Spain were younger at disease onset and showed an increased risk of having extraintestinal manifestations and using biologics. Our study suggests a featured phenotype of immigrant IBD patients in Spain, and constitutes a new landmark in the epidemiological characterization of immigrant IBD populations in Southern Europe.
Filiaciones:
Gutierrez, A:
Hosp Gen Univ Alicante, Serv Med Digest, Alicante, Spain
Hosp Gen Univ Alicante, IIS Isabial, Alicante, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Zapater, P:
Hosp Gen Univ Alicante, IIS Isabial, Alicante, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Gen Univ Alicante, Unidad Farmacol Clin, Alicante, Spain
Univ Miguel Hernandez, Inst IDIBE, Alacant, Spain
Ricart, E:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Serv Med Digest Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain
Gonzalez-Vivo, M:
Hosp del Mar, IMIM Hosp Mar Med Res Inst, Serv Med Digest, Barcelona, Spain
Gordillo, J:
Hosp Santa Creu & Sant Pau, Serv Patol Digest, Barcelona, Spain
Olivares, D:
Hosp Univ Clin San Carlos, Med Digest, Madrid, Spain
Vera, I:
Hosp Univ Puerta Hierro, Serv Aparato Digest, Madrid, Spain
Manosa, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Badalona Germans Trias & Pujol, Serv Aparato Digest, Badalona, Spain
Gisbert, JP:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Univ Autonoma Madrid UAM, Inst Invest Sanitaria Princesa IIS IP, Hosp Univ Princesa, Serv Aparato Digest, Madrid, Spain
Aguas, M:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ La Fe, Serv Med Digest, Valencia, Spain
Sanchez-Rodriguez, E:
Hosp Univ Ramon & Cajal, Serv Med Digest, Madrid, Spain
Bosca-Watts, M:
Hosp Clin Univ Valencia, Serv Med Digest, Valencia, Spain
Laredo, V:
Hosp Clin Univ Lozano Blesa, Serv Med Digest, Zaragoza, Spain
Camps, B:
Hosp Univ Bellvitge, Serv Med Digest, Barcelona, Spain
Marin-Jimenez, I:
Hosp Gregorio Maranon, Serv Med Digest, Madrid, Spain
Inst Invest Biomed Gregorio Maranon IiSGM, Gastroenterol Dept, Madrid, Spain
Zabana, Y:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ Mutua Terrassa, Serv Med Digest, Terrassa, Spain
Martin-Arranz, MD:
Hosp La Paz, Serv Med Digest, Madrid, Spain
Munoz, R:
Hosp Gen Univ Alicante, Serv Med Digest, Alicante, Spain
Navarro, M:
Hosp St Joan Despi Moises Broggi, Serv Med Digest, Barcelona, Spain
Sierra, E:
Hosp Univ Miguel Servert, Serv Med Digest, Zaragoza, Spain
Madero, L:
Hosp Gen Univ Elche, Serv Med Digest, Elche, Spain
Vela, M:
Hosp Nuestra Senora Candelaria, Serv Med Digest, Santa Cruz De Tenerife, Spain
Perez-Calle, JL:
Hosp Univ Fdn Alcorcon, Serv Med Digest, Madrid, Spain
Sainz, E:
Hosp St Joan Deu Althaia, Serv Med Digest, Manresa, Spain
Calvet, X:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Univ Autonoma Barcelona UAB, Inst Univ Parc Tauli, Hosp Sabadell, Unitat Malalties Digest, Barcelona, Spain
Arias, L:
Hosp Univ Burgos, Serv Med Digest, Burgos, Spain
Morales, V:
Hosp Gen Granollers, Serv Med Digest, Barcelona, Spain
Bermejo, F:
Hosp Fuenlabrada, Serv Med Digest, Fuenlabrada, Spain
IIS Hosp Paz IdiPaz Madrid, Madrid, Spain
Fernandez-Salazar, L:
Hosp Clin Valladolid, Serv Med Digest, Madrid, Spain
Van Domselaar, M:
Hosp Torrejon Ardoz, Serv Med Digest, Madrid, Spain
De Castro, L:
SERGAS UVIG, IIS Galicia Sur, Xerencia Xest Integrada Vigo SERGAS, Dept Gastroenterol, Vigo, Spain
Rodriguez, C:
Complejo Hosp Navarra, Serv Med Digest, Pamplona, Spain
Munoz-Villafranca, C:
Hosp Univ Basurto, Serv Med Digest, Bilbao, Spain
Lorente, R:
Hosp Gen Ciudad Real, Serv Med Digest, Ciudad Real, Spain
Rivero, M:
Hosp Univ Marques Valdecilla & IDIVAL, Serv Med Digest, Santander, Spain
Iglesias, E:
Hosp Univ Reina Sofia, Serv Med Digest, Cordoba, Spain
Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain
Herreros, B:
Hosp Marina Baixa, Serv Med Digest, Villajoyosa, Spain
Busquets, D:
Hosp Girona Dr Trueta ICO, Serv Med Digest, Girona, Spain
Riera, J:
Hosp Univ Son LLatzer, Serv Med Digest, Palma de Mallorca, Spain
Martinez-Montiel, MP:
Hosp 12 Octubre, Serv Med Digest, Madrid, Spain
Roldon, M:
Hosp San Jorge, Serv Cirugia Gen & Aparato Digest, Huesca, Spain
Roncero, O:
Hosp Gen La Mancha Ctr, Serv Med Digest, Ciudad Real, Spain
Hinojosa, E:
Hosp Manises, Serv Med Digest, Valencia, Spain
Sierra, M:
Complejo Asistencial Univ Leon, Serv Med Digest, Leon, Spain
Barrio, J:
Hosp Univ Rio Hortega, Valladolid, Spain
Huguet, J:
Hosp Univ Cent Asturias, Oviedo, Spain
ISPA, Oviedo, Spain
Consorcio Hosp Gen Univ Valencia, Valencia, Spain
Merino, O:
Hosp Cruces, Serv Med Digest, Bilbao, Spain
Carpio, D:
Complejo Hosp Univ Pontevedra, Pontevedra, Spain
Ginard, D:
Hosp Univ Son Espases, Serv Med Digest, Palma De Mallorca, Spain
Munoz, F:
Hosp Clin Univ Salamanca, Serv Med Digest, Salamanca, Spain
Marta, P:
Consorci Sanitari Terrasa, Serv Med Digest, Barcelona, Spain
Almela, P:
Hosp Gen Univ Castellon, Serv Med Digest, Castellon La Plana, Spain
Argueelles-Arias, F:
Hosp Univ Virgen Macarena, Serv Med Digest, Seville, Spain
Alcain, G:
Hosp Clin Virgen Victoria, Serv Med Digest, Malaga, Spain
Luis, B:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Univ Donostia, Serv Med Digest, San Sebastian, Spain
Univ Basque Country, Inst Biodonostia, San Sebastian, Spain
Mancenido, N:
Hosp Infanta Sofia, Serv Med Digest, Madrid, Spain
Lucendo, AJ:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Gen Tomelloso, Serv Med Digest, Ciudad Real, Spain
Varela, P:
Hosp Cabuenes, Serv Med Digest, Gijon, Spain
Rodriguez-Lago, I:
Hosp Univ Galdakao, Serv Aparato Digest, IIS Biocruces, Galdakao, Spain
Univ Deusto, Fac Med, Bilbao, Spain
Ramos, L:
Hosp Univ La Laguna, Serv Med Digest, Santa Cruz Tenerife, CA USA
Laura, S:
Hosp Gen Univ Alicante, Serv Med Digest, Alicante, Spain
Hosp Gen Univ Alicante, IIS Isabial, Alicante, Spain
Sese, E:
Hosp Arnau Vilanova, Serv Med Digest, Lleida, Spain
Acosta, MBD:
Hosp Univ Santiago, Serv Aparato Digest, Santiago De Compostela, Spain
Domenech, E:
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Hosp Badalona Germans Trias & Pujol, Serv Aparato Digest, Badalona, Spain
Frances, R:
Hosp Gen Univ Alicante, IIS Isabial, Alicante, Spain
Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain
Univ Miguel Hernandez, Hepat & Intestinal Immunobiol Grp, Dpto Med Clin, San Juan, Spain
Univ Miguel Hernandez, Inst Invest Desarrollo Innovac Biotecnol Sanitari, Elche, Spain
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